Associations between depressive symptoms, cigarette smoking, and cardiovascular health: Longitudinal results from CARDIA

Allison J. Carroll, Mark D. Huffman, Lihui Zhao, David R. Jacobs, Jesse C. Stewart, Catarina I. Kiefe, Wendy Brunner, Kiang Liu, Brian Hitsman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Introduction: Depression is associated with increased risk of incident and recurrent cardiovascular disease, while the association between depression and cardiovascular health (CVH) remains unknown. Because the natural course of depression varies widely, different patterns of depression, as well as co-occurring factors such as cigarette smoking, may influence this relationship. We examined potential interactions between longitudinal patterns of depression and smoking with CVH. Methods: Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, we modeled trajectories of depression (Center for Epidemiologic Studies Depression scale scores; Years 5, 10, 15, 20) and smoking (cigarettes/day; Years 0, 2, 5, 7, 10, 15, 20). We calculated a modified American Heart Association (AHA) CVH Score (weight, blood glucose, cholesterol, blood pressure, physical activity, and diet; Year 20); higher scores indicate better CVH. Generalized linear models evaluated associations between depression trajectories, smoking trajectories, and their interaction with CVH Score. Results: The depression trajectory x smoking trajectory interaction was not associated with CVH Score, but main effects of depression trajectory (p <.001) and smoking trajectory (p <.001) were observed. Participants with patterns of subthreshold depression (β = −0.26, SE=0.08), increasing depression (β = −0.51 SE = 0.14), and high depression (β = −0.65, SE = 0.32) had lower CVH Scores than those without depression. Compared to never smokers, participants who quit smoking had higher CVH Scores (β = 0.38, SE = 0.11), while participants with the greatest smoking exposure had lower CVH Scores (β = −0.49, SE = 0.22). Limitations: CVH Scores were adapted from the AHA guidelines based on the available CARDIA data. Conclusions: Deleterious depression and smoking trajectories are independently but not synergistically associated with worse CVH.

Original languageEnglish (US)
Pages (from-to)583-591
Number of pages9
JournalJournal of Affective Disorders
StatePublished - Jan 1 2020

Bibliographical note

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C & HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI ( AG0005 ). This manuscript has been reviewed by CARDIA for scientific content. Allison Carroll was supported by a Predoctoral Individual National Research Service Award from the National Heart, Lung, and Blood Institute ( F31 HL129494 ). The funding agencies had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review, or approval of this article.

Funding Information:
Mark Huffman receives grant support from the World Heart Federation to serve as its senior program advisor for the Emerging Leaders program, which is sponsored by Boehringer Ingelheim and Novartis with prior support from BUPA and AstraZeneca. He also receives support from One Brave IdeaTM, a research enterprise supported by the American Heart Association , Verily, and AstraZeneca unrelated to this work.

Publisher Copyright:
© 2019 Elsevier B.V.


  • Cardiovascular health
  • Depression
  • Health risk behaviors
  • Prospective study
  • Smoking
  • Trajectory modeling

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

Fingerprint Dive into the research topics of 'Associations between depressive symptoms, cigarette smoking, and cardiovascular health: Longitudinal results from CARDIA'. Together they form a unique fingerprint.

Cite this