Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

Michelle C. Johansen; Wendy Wang; Michael J Zhang; Alvaro Alonso; Dean F. Wong; Rebecca F. Gottesman; Lin Y. Chen

doi:10.3233/JAD-215378

Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

Michelle C. Johansen, Wendy Wang, Michael J Zhang, Alvaro Alonso, Dean F. Wong, Rebecca F. Gottesman, Lin Y. Chen

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

Original language	English (US)
Pages (from-to)	43-48
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	86
Issue number	1
DOIs	https://doi.org/10.3233/JAD-215378
State	Published - 2022

Bibliographical note

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by NHLBI contracts (HHSN268201700001I, HHSN26 8201700002I, HHSN268201700003I HHSN268201 700005I, HHSN268201700004I). The ARIC-PET study is funded by the NIA (R01AG040282, previously to RG). Avid Radiopharmaceuticals provided the florbetapir isotope for the study, but had no role in the study design or interpretation of results. Dr. Johansen receives funding from the NINDS (K23NS 112459); Dr. Gottesman received prior funding from the NIA (K24AG052573). Dr. Alonso receives funding from the NIH (K24HL148521, P30AG066 511). Dr. Chen receives funding from the NIH (R01H L126637, R01HL141288, and K24HL155813) iRHYTHM (the manufacturer of Zio©XT) did not contribute any funding nor to analysis or drafting of the manuscript in any way.

Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by NHLBI contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I HHSN268201700005I, HHSN268201700004I). The ARIC-PET study is funded by the NIA (R01AG040282, previously to RG). Avid Radiopharmaceuticals provided the florbetapir isotope for the study, but had no role in the study design or interpretation of results. Dr. Johansen receives funding from the NINDS (K23NS112459); Dr. Gottesman received prior funding from the NIA (K24AG052573). Dr. Alonso receives funding from the NIH (K24HL148521, P30AG066511). Dr. Chen receives funding from the NIH (R01HL126637, R01HL141288, and K24HL155813).

Publisher Copyright:
© 2022-IOS Press. All rights reserved.

Keywords

Arrhythmias
atrial fibrillation
cognitive impairment
imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.3233/JAD-215378

Find It

Find It at U of M Libraries

Cite this

@article{6439539db7824a14b53544e878438e58,

title = "Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study",

abstract = "The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio{\textregistered} XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.",

keywords = "Arrhythmias, atrial fibrillation, cognitive impairment, imaging",

author = "Johansen, {Michelle C.} and Wendy Wang and Zhang, {Michael J} and Alvaro Alonso and Wong, {Dean F.} and Gottesman, {Rebecca F.} and Chen, {Lin Y.}",

note = "Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by NHLBI contracts (HHSN268201700001I, HHSN26 8201700002I, HHSN268201700003I HHSN268201 700005I, HHSN268201700004I). The ARIC-PET study is funded by the NIA (R01AG040282, previously to RG). Avid Radiopharmaceuticals provided the florbetapir isotope for the study, but had no role in the study design or interpretation of results. Dr. Johansen receives funding from the NINDS (K23NS 112459); Dr. Gottesman received prior funding from the NIA (K24AG052573). Dr. Alonso receives funding from the NIH (K24HL148521, P30AG066 511). Dr. Chen receives funding from the NIH (R01H L126637, R01HL141288, and K24HL155813) iRHYTHM (the manufacturer of Zio{\textcopyright}XT) did not contribute any funding nor to analysis or drafting of the manuscript in any way. Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by NHLBI contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I HHSN268201700005I, HHSN268201700004I). The ARIC-PET study is funded by the NIA (R01AG040282, previously to RG). Avid Radiopharmaceuticals provided the florbetapir isotope for the study, but had no role in the study design or interpretation of results. Dr. Johansen receives funding from the NINDS (K23NS112459); Dr. Gottesman received prior funding from the NIA (K24AG052573). Dr. Alonso receives funding from the NIH (K24HL148521, P30AG066511). Dr. Chen receives funding from the NIH (R01HL126637, R01HL141288, and K24HL155813). Publisher Copyright: {\textcopyright} 2022-IOS Press. All rights reserved.",

year = "2022",

doi = "10.3233/JAD-215378",

language = "English (US)",

volume = "86",

pages = "43--48",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "1",

}

TY - JOUR

T1 - Associations between Atrial Arrhythmias and Brain Amyloid Deposition

T2 - The ARIC-PET Study

AU - Johansen, Michelle C.

AU - Wang, Wendy

AU - Zhang, Michael J

AU - Alonso, Alvaro

AU - Wong, Dean F.

AU - Gottesman, Rebecca F.

AU - Chen, Lin Y.

N1 - Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by NHLBI contracts (HHSN268201700001I, HHSN26 8201700002I, HHSN268201700003I HHSN268201 700005I, HHSN268201700004I). The ARIC-PET study is funded by the NIA (R01AG040282, previously to RG). Avid Radiopharmaceuticals provided the florbetapir isotope for the study, but had no role in the study design or interpretation of results. Dr. Johansen receives funding from the NINDS (K23NS 112459); Dr. Gottesman received prior funding from the NIA (K24AG052573). Dr. Alonso receives funding from the NIH (K24HL148521, P30AG066 511). Dr. Chen receives funding from the NIH (R01H L126637, R01HL141288, and K24HL155813) iRHYTHM (the manufacturer of Zio©XT) did not contribute any funding nor to analysis or drafting of the manuscript in any way. Funding Information: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by NHLBI contracts (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I HHSN268201700005I, HHSN268201700004I). The ARIC-PET study is funded by the NIA (R01AG040282, previously to RG). Avid Radiopharmaceuticals provided the florbetapir isotope for the study, but had no role in the study design or interpretation of results. Dr. Johansen receives funding from the NINDS (K23NS112459); Dr. Gottesman received prior funding from the NIA (K24AG052573). Dr. Alonso receives funding from the NIH (K24HL148521, P30AG066511). Dr. Chen receives funding from the NIH (R01HL126637, R01HL141288, and K24HL155813). Publisher Copyright: © 2022-IOS Press. All rights reserved.

PY - 2022

Y1 - 2022

N2 - The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

AB - The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

KW - Arrhythmias

KW - atrial fibrillation

KW - cognitive impairment

KW - imaging

UR - http://www.scopus.com/inward/record.url?scp=85126389494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85126389494&partnerID=8YFLogxK

U2 - 10.3233/JAD-215378

DO - 10.3233/JAD-215378

M3 - Article

C2 - 35001894

AN - SCOPUS:85126389494

SN - 1387-2877

VL - 86

SP - 43

EP - 48

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this