Associations among diurnal salivary cortisol patterns, medication use, and behavioral phenotype features in a community sample of rett syndrome

Breanne J. Byiers; Ameante Payen; Timothy J Feyma; Angela Panoskaltsis-Mortari; Michael J. Ehrhardt; Frank J. Symons

doi:10.1352/1944-7558-125.5.353

Associations among diurnal salivary cortisol patterns, medication use, and behavioral phenotype features in a community sample of rett syndrome

Breanne J. Byiers, Ameante Payen, Timothy J Feyma, Angela Panoskaltsis-Mortari, Michael J. Ehrhardt, Frank J. Symons

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Rett syndrome (RTT) is a severe neurodevelopmental disorder resulting from mutations of the MECP2 gene. Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and abnormal stress responses have been observed in animal models of RTT, but little is known about HPA axis function among individuals with RTT. Diurnal salivary cortisol patterns from 30 females with RTT were examined in relation to mutation type, medication use, and features of the RTT behavioral phenotype. Cortisol patterns were significantly related to mutation severity, anticonvulsant medication status, and bruxism (tooth grinding). This study provides preliminary support for the hypothesis that RTT may be at risk for outcomes associated with aberrant HPA axis function, and that this risk may be mediated by mutation type.

Original language	English (US)
Pages (from-to)	353-368
Number of pages	16
Journal	American journal on intellectual and developmental disabilities
Volume	125
Issue number	5
DOIs	https://doi.org/10.1352/1944-7558-125.5.353
State	Published - Sep 1 2020

Bibliographical note

Funding Information:
Funding for this study was provided by Rettsyndrome.org (grant #3116), the Mayday Fund (grant #11211) from the Mayday Fund, and the Eunice Kennedy Shriver National Institute for Child Health and Human Development (grants #44764, 101075). The authors gratefully acknowledge all of the families who participated in the study, as well the Gillette Children's Specialty Healthcare Rett Syndrome Clinic, the Midwest Rett Syndrome Foundation, and RettSyndrome.org for their assistance.

Publisher Copyright:
© 2020 American Association on Mental Retardation. All rights reserved.

Keywords

HPA axis
Rett syndrome
Salivary cortisol
Stress physiology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1352/1944-7558-125.5.353

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Byiers, B. J., Payen, A., Feyma, T. J., Panoskaltsis-Mortari, A., Ehrhardt, M. J., & Symons, F. J. (2020). Associations among diurnal salivary cortisol patterns, medication use, and behavioral phenotype features in a community sample of rett syndrome. American journal on intellectual and developmental disabilities, 125(5), 353-368. https://doi.org/10.1352/1944-7558-125.5.353

Associations among diurnal salivary cortisol patterns, medication use, and behavioral phenotype features in a community sample of rett syndrome. / Byiers, Breanne J.; Payen, Ameante; Feyma, Timothy J et al.

In: American journal on intellectual and developmental disabilities, Vol. 125, No. 5, 01.09.2020, p. 353-368.

Research output: Contribution to journal › Article › peer-review

Byiers, BJ, Payen, A, Feyma, TJ, Panoskaltsis-Mortari, A , Ehrhardt, MJ & Symons, FJ 2020, 'Associations among diurnal salivary cortisol patterns, medication use, and behavioral phenotype features in a community sample of rett syndrome', American journal on intellectual and developmental disabilities, vol. 125, no. 5, pp. 353-368. https://doi.org/10.1352/1944-7558-125.5.353

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Associations among diurnal salivary cortisol patterns, medication use, and behavioral phenotype features in a community sample of rett syndrome

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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