Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population

Lisa M. Ambrose-Lanci, Meera Vaswani, Toni Kim Clarke, Angela Zeng, Falk W. Lohoff, Thomas N. Ferraro, Wade H. Berrettini

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The rewarding properties of drugs of abuse are mediated by the mu-opioid receptor (MOR). Genetic variations in MOR and MOR interacting proteins (MORIPs) involved in MOR signaling may increase the risk for drug dependence. The MORIP β-arrestin plays an important role in the regulation of MOR trafficking, thereby highlighting it as a candidate gene for addiction phenotypes. In this case-control association study, DNA samples from cocaine-dependent (n=336) and opioid-dependent (n=335) patients and controls (n=656) were genotyped for seven single nucleotide polymorphisms (rs11868227, rs3786047, rs4522461, rs1045280, rs2271167, rs2036657, and rs4790694) across ARRB2, the gene encoding the β-arrestin 2 protein. No significant differences were observed in genotype or allele frequency between drug-dependent and control individuals for any of the single nucleotide polymorphisms analyzed. Haplotype analysis was similarly negative. Further studies are needed to determine whether variations in ARRB2 (or other MORIPs) are relevant to cocaine or opioid dependence in different ethnic populations or whether they confer a risk that is specific to dependence on other drugs of abuse.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalPsychiatric Genetics
Volume22
Issue number3
DOIs
StatePublished - Jun 2012

Keywords

  • AARB2
  • case-control association study
  • cocaine dependence
  • opioid dependence

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