Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort

Satagopan Uthra, Rajiv Raman, Bickol N. Mukesh, Samuel A. Rajkumar, Kumari R. Padmaja, Pradeep G. Paul, Praveena Lakshmipathy, Perumal Gnanamoorthy, Tarun Sharma, Catherine A. McCarty, Govindasamy Kumaramanickavel

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48 Scopus citations

Abstract

Background: Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR. Materials and Methods: Type 2 diabetic patients with and without retinopathy were recruited. The -634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests. Results: No significant association was observed between genotypes, alleles and haplotypes of -634C/G and 936C/T polymorphisms and DR or its severity. However, C(-634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3). Conclusion: Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalOphthalmic Genetics
Volume29
Issue number1
DOIs
StatePublished - Mar 1 2008

Keywords

  • Diabetic retinopathy
  • Genetic polymorphism
  • South India
  • Type 2 diabetes
  • VEGF

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