Association of VEGF gene polymorphisms with diabetic retinopathy in a south Indian cohort

Satagopan Uthra, Rajiv Raman, Bickol N. Mukesh, Samuel A. Rajkumar, Kumari R. Padmaja, Pradeep G. Paul, Praveena Lakshmipathy, Perumal Gnanamoorthy, Tarun Sharma, Catherine A. McCarty, Govindasamy Kumaramanickavel

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Background: Polymorphisms in vascular endothelial growth factor (VEGF) gene have been associated with diabetic retinopathy (DR) in various populations. A promoter polymorphism and a 3'UTR variation are studied for association with DR. Materials and Methods: Type 2 diabetic patients with and without retinopathy were recruited. The -634C/G and 936C/T polymorphisms were genotyped by direct sequencing and their frequencies were analyzed using relevant statistical tests. Results: No significant association was observed between genotypes, alleles and haplotypes of -634C/G and 936C/T polymorphisms and DR or its severity. However, C(-634)G genotype was found to increase the risk for DR in patients with microalbuminuria (OR: 8.9, 95% CI: 1.4, 58.3). Conclusion: Our study broadly suggests lack of association of VEGF gene polymorphisms with DR.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalOphthalmic Genetics
Volume29
Issue number1
DOIs
StatePublished - Mar 2008

Bibliographical note

Funding Information:
Shri Baghawan Mahavir Vitreo-Retinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India

Funding Information:
Sankara Nethralaya Diabetic Retinopathy Project, Medical Research Foundation, Chennai, India

Funding Information:
Sankara Nethralaya Diabetic Retinopathy Project, Medical Research Foundation, Sankara Nethralaya, Chennai, India

Funding Information:
We thank RD TATA Trust, Mumbai, India, for the financial grant and patients who participated in the study. We are very thankful to the Sankara Nethralaya Diabetic retinopathy project team for collecting the patients.

Keywords

  • Diabetic retinopathy
  • Genetic polymorphism
  • South India
  • Type 2 diabetes
  • VEGF

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