Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

Jose R. Castillo-Mancilla, Andrew N. Phillips, James D. Neaton, Jacqueline Neuhaus, Simon Collins, Sharon Mannheimer, Sarah Pett, Veronique Touzeau-Römer, Mark N. Polizzotto, Jens D. Lundgren, Edward M. Gardner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.

Original languageEnglish (US)
Article numberofx275
JournalOpen Forum Infectious Diseases
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2018

Bibliographical note

Funding Information:
Financial support. This work was supported by National Institute of Health grants: U01AI068641, U01AI042170 and U01AI46362 (SMART) and K23AI104315 (JCM) and R21AI124859 (JCM).

Publisher Copyright:
© 2017 The Author(s).

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • Adherence
  • SMART study.
  • antiretroviral therapy
  • inflammation

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