Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

Umang Swami; Pedro Isaacsson Velho; Roberto Nussenzveig; Jonathan Chipman; Victor Sacristan Santos; Stephanie Erickson; Divya Dharmaraj; Ajjai Shivaram Alva; Ulka N. Vaishampayan; John Esther; Andrew W. Hahn; Benjamin Louis Maughan; Emmanuel S. Antonarakis; Neeraj Agarwal

doi:10.1016/j.eururo.2020.06.033

Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

Umang Swami
, Pedro Isaacsson Velho
, Roberto Nussenzveig
, Jonathan Chipman
, Victor Sacristan Santos
, Stephanie Erickson
, Divya Dharmaraj
, Ajjai Shivaram Alva
, Ulka N. Vaishampayan
, John Esther
, Andrew W. Hahn
, Benjamin Louis Maughan
, Emmanuel S. Antonarakis
, Neeraj Agarwal

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.

Original language	English (US)
Pages (from-to)	652-656
Number of pages	5
Journal	European Urology
Volume	78
Issue number	5
DOIs	https://doi.org/10.1016/j.eururo.2020.06.033
State	Published - Nov 2020
Externally published	Yes

Bibliographical note

Funding Information:
Funding/Support and role of the sponsor: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number P30CA042014 to Huntsman Cancer Institute at the University of Utah, P30CA006973 to Sidney Kimmel Comprehensive Cancer Center at John Hopkins University, and 3P30CA042014-25S2 to N. Agarwal. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
© 2020 European Association of Urology

Keywords

Androgen deprivation therapy
Metastatic hormone-sensitive prostate cancer
Overall survival
Progression-free survival
SPOP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eururo.2020.06.033

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Swami, U., Isaacsson Velho, P., Nussenzveig, R., Chipman, J., Sacristan Santos, V., Erickson, S., Dharmaraj, D., Alva, A. S., Vaishampayan, U. N., Esther, J., Hahn, A. W., Maughan, B. L., Antonarakis, E. S., & Agarwal, N. (2020). Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer. European Urology, 78(5), 652-656. https://doi.org/10.1016/j.eururo.2020.06.033

Swami, U, Isaacsson Velho, P, Nussenzveig, R, Chipman, J, Sacristan Santos, V, Erickson, S, Dharmaraj, D, Alva, AS, Vaishampayan, UN, Esther, J, Hahn, AW, Maughan, BL, Antonarakis, ES & Agarwal, N 2020, 'Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer', European Urology, vol. 78, no. 5, pp. 652-656. https://doi.org/10.1016/j.eururo.2020.06.033

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title = "Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer",

abstract = "Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.",

keywords = "Androgen deprivation therapy, Metastatic hormone-sensitive prostate cancer, Overall survival, Progression-free survival, SPOP",

author = "Umang Swami and \{Isaacsson Velho\}, Pedro and Roberto Nussenzveig and Jonathan Chipman and \{Sacristan Santos\}, Victor and Stephanie Erickson and Divya Dharmaraj and Alva, \{Ajjai Shivaram\} and Vaishampayan, \{Ulka N.\} and John Esther and Hahn, \{Andrew W.\} and Maughan, \{Benjamin Louis\} and Antonarakis, \{Emmanuel S.\} and Neeraj Agarwal",

note = "Funding Information: Funding/Support and role of the sponsor: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number P30CA042014 to Huntsman Cancer Institute at the University of Utah, P30CA006973 to Sidney Kimmel Comprehensive Cancer Center at John Hopkins University, and 3P30CA042014-25S2 to N. Agarwal. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2020 European Association of Urology",

year = "2020",

month = nov,

doi = "10.1016/j.eururo.2020.06.033",

language = "English (US)",

volume = "78",

pages = "652--656",

journal = "European Urology",

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AU - Swami, Umang

AU - Isaacsson Velho, Pedro

AU - Nussenzveig, Roberto

AU - Chipman, Jonathan

AU - Sacristan Santos, Victor

AU - Erickson, Stephanie

AU - Dharmaraj, Divya

AU - Alva, Ajjai Shivaram

AU - Vaishampayan, Ulka N.

AU - Esther, John

AU - Hahn, Andrew W.

AU - Maughan, Benjamin Louis

AU - Antonarakis, Emmanuel S.

AU - Agarwal, Neeraj

N1 - Funding Information: Funding/Support and role of the sponsor: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number P30CA042014 to Huntsman Cancer Institute at the University of Utah, P30CA006973 to Sidney Kimmel Comprehensive Cancer Center at John Hopkins University, and 3P30CA042014-25S2 to N. Agarwal. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: © 2020 European Association of Urology

PY - 2020/11

Y1 - 2020/11

N2 - Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.

AB - Presence of tumor mutation in speckle-type pox virus and zinc finger protein (SPOP) gene was associated with improved survival outcomes in men with de novo metastatic castration-sensitive prostate cancer receiving standard androgen deprivation therapy.

KW - Androgen deprivation therapy

KW - Metastatic hormone-sensitive prostate cancer

KW - Overall survival

KW - Progression-free survival

KW - SPOP

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UR - https://www.scopus.com/pages/publications/85087308453#tab=citedBy

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DO - 10.1016/j.eururo.2020.06.033

M3 - Article

C2 - 32624276

AN - SCOPUS:85087308453

SN - 0302-2838

VL - 78

SP - 652

EP - 656

JO - European Urology

JF - European Urology

IS - 5

ER -

Association of SPOP Mutations with Outcomes in Men with De Novo Metastatic Castration-sensitive Prostate Cancer

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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