Association of smoking and right ventricular function in middle age: CARDIA study

Henrique T. Moreira; Anderson C. Armstrong; Chike C. Nwabuo; Henrique D. Vasconcellos; Andre Schmidt; Ravi K. Sharma; Bharath Ambale-Venkatesh; Mohammad R. Ostovaneh; Catarina I. Kiefe; Cora E. Lewis; Pamela J. Schreiner; Stephen Sidney; Kofo O. Ogunyankin; Samuel S. Gidding; Joao A.C. Lima

doi:10.1136/openhrt-2020-001270

Association of smoking and right ventricular function in middle age: CARDIA study

Henrique T. Moreira, Anderson C. Armstrong, Chike C. Nwabuo, Henrique D. Vasconcellos, Andre Schmidt, Ravi K. Sharma, Bharath Ambale-Venkatesh, Mohammad R. Ostovaneh, Catarina I. Kiefe, Cora E. Lewis, Pamela J. Schreiner, Stephen Sidney, Kofo O. Ogunyankin, Samuel S. Gidding, Joao A.C. Lima

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective: To evaluate the association of cigarette smoking and right ventricular (RV) systolic and diastolic functions in a population-based cohort of individuals at middle age.

Methods: This cross-sectional study included participants who answered the smoking questionnaire and underwent echocardiography at the Coronary Artery Risk Development in Young Adulthood year 25 examination. RV systolic function was assessed by echocardiographic-derived tricuspid annular plane systolic excursion (TAPSE) and by right ventricular peak systolic velocity (RVS'), while RV diastolic function was evaluated by early right ventricular tissue velocity (RVE'). Multivariable linear regression models assessed the relationship of smoking with RV function, adjusting for age, sex, race, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes mellitus, alcohol consumption, pulmonary function, left ventricular systolic and diastolic function and coronary artery calcium score.

Results: A total of 3424 participants were included. The mean age was 50±4 years; 57% were female; and 53% were black. There were 2106 (61%) never smokers, 750 (22%) former smokers and 589 (17%) current smokers. In the multivariable analysis, current smokers had significantly lower TAPSE (β=-0.082, SE=0.031, p=0.008), RVS' (β=-0.343, SE=0.156, p=0.028) and RVE' (β=-0.715, SE=0.195, p<0.001) compared with never smokers. Former smokers had a significantly lower RVE' compared with never smokers (β=-0.414, SE=0.162, p=0.011), whereas no significant difference in RV systolic function was found between former smokers and never smokers.

Conclusions: In a large multicenter community-based biracial cohort of middle-aged individuals, smoking was independently related to both worse RV systolic and diastolic functions.

Original language	English (US)
Article number	e001270
Journal	Open Heart
Volume	7
Issue number	1
DOIs	https://doi.org/10.1136/openhrt-2020-001270
State	Published - Mar 8 2020

Bibliographical note

Funding Information:
Funding The Coronary Artery Risk Development in Young Adults Study is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I and HHSN268201800007I from the National Heart, Lung, and Blood Institute.

Publisher Copyright:
© © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

Keywords

cardiac function
echocardiography
smoking
Predictive Value of Tests
Smokers
Age Factors
Cross-Sectional Studies
Risk Assessment
United States
Humans
Middle Aged
Non-Smokers
Risk Factors
Male
Smoking/adverse effects
Ventricular Dysfunction, Right/diagnostic imaging
Echocardiography, Doppler
Female
Ex-Smokers
Ventricular Function, Right

PubMed: MeSH publication types

Multicenter Study
Journal Article
Research Support, N.I.H., Extramural
Comparative Study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/openhrt-2020-001270

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Moreira, H. T., Armstrong, A. C., Nwabuo, C. C., Vasconcellos, H. D., Schmidt, A., Sharma, R. K., Ambale-Venkatesh, B., Ostovaneh, M. R., Kiefe, C. I., Lewis, C. E., Schreiner, P. J., Sidney, S., Ogunyankin, K. O., Gidding, S. S., & Lima, J. A. C. (2020). Association of smoking and right ventricular function in middle age: CARDIA study. Open Heart, 7(1), [e001270]. https://doi.org/10.1136/openhrt-2020-001270

Moreira, HT, Armstrong, AC, Nwabuo, CC, Vasconcellos, HD, Schmidt, A, Sharma, RK, Ambale-Venkatesh, B, Ostovaneh, MR, Kiefe, CI, Lewis, CE, Schreiner, PJ, Sidney, S, Ogunyankin, KO, Gidding, SS & Lima, JAC 2020, 'Association of smoking and right ventricular function in middle age: CARDIA study', Open Heart, vol. 7, no. 1, e001270. https://doi.org/10.1136/openhrt-2020-001270

@article{b5ba0e5cc085448182a20f9f1c0a272a,

title = "Association of smoking and right ventricular function in middle age: CARDIA study",

abstract = "Objective: To evaluate the association of cigarette smoking and right ventricular (RV) systolic and diastolic functions in a population-based cohort of individuals at middle age.Methods: This cross-sectional study included participants who answered the smoking questionnaire and underwent echocardiography at the Coronary Artery Risk Development in Young Adulthood year 25 examination. RV systolic function was assessed by echocardiographic-derived tricuspid annular plane systolic excursion (TAPSE) and by right ventricular peak systolic velocity (RVS'), while RV diastolic function was evaluated by early right ventricular tissue velocity (RVE'). Multivariable linear regression models assessed the relationship of smoking with RV function, adjusting for age, sex, race, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes mellitus, alcohol consumption, pulmonary function, left ventricular systolic and diastolic function and coronary artery calcium score.Results: A total of 3424 participants were included. The mean age was 50±4 years; 57% were female; and 53% were black. There were 2106 (61%) never smokers, 750 (22%) former smokers and 589 (17%) current smokers. In the multivariable analysis, current smokers had significantly lower TAPSE (β=-0.082, SE=0.031, p=0.008), RVS' (β=-0.343, SE=0.156, p=0.028) and RVE' (β=-0.715, SE=0.195, p<0.001) compared with never smokers. Former smokers had a significantly lower RVE' compared with never smokers (β=-0.414, SE=0.162, p=0.011), whereas no significant difference in RV systolic function was found between former smokers and never smokers.Conclusions: In a large multicenter community-based biracial cohort of middle-aged individuals, smoking was independently related to both worse RV systolic and diastolic functions.",

keywords = "cardiac function, echocardiography, smoking, Predictive Value of Tests, Smokers, Age Factors, Cross-Sectional Studies, Risk Assessment, United States, Humans, Middle Aged, Non-Smokers, Risk Factors, Male, Smoking/adverse effects, Ventricular Dysfunction, Right/diagnostic imaging, Echocardiography, Doppler, Female, Ex-Smokers, Ventricular Function, Right",

author = "Moreira, {Henrique T.} and Armstrong, {Anderson C.} and Nwabuo, {Chike C.} and Vasconcellos, {Henrique D.} and Andre Schmidt and Sharma, {Ravi K.} and Bharath Ambale-Venkatesh and Ostovaneh, {Mohammad R.} and Kiefe, {Catarina I.} and Lewis, {Cora E.} and Schreiner, {Pamela J.} and Stephen Sidney and Ogunyankin, {Kofo O.} and Gidding, {Samuel S.} and Lima, {Joao A.C.}",

note = "Funding Information: Funding The Coronary Artery Risk Development in Young Adults Study is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I and HHSN268201800007I from the National Heart, Lung, and Blood Institute. Publisher Copyright: {\textcopyright} {\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.",

year = "2020",

month = mar,

day = "8",

doi = "10.1136/openhrt-2020-001270",

language = "English (US)",

volume = "7",

journal = "Open Heart",

issn = "2053-3624",

publisher = "BMJ Publishing Group",

number = "1",

}

TY - JOUR

T1 - Association of smoking and right ventricular function in middle age

T2 - CARDIA study

AU - Moreira, Henrique T.

AU - Armstrong, Anderson C.

AU - Nwabuo, Chike C.

AU - Vasconcellos, Henrique D.

AU - Schmidt, Andre

AU - Sharma, Ravi K.

AU - Ambale-Venkatesh, Bharath

AU - Ostovaneh, Mohammad R.

AU - Kiefe, Catarina I.

AU - Lewis, Cora E.

AU - Schreiner, Pamela J.

AU - Sidney, Stephen

AU - Ogunyankin, Kofo O.

AU - Gidding, Samuel S.

AU - Lima, Joao A.C.

N1 - Funding Information: Funding The Coronary Artery Risk Development in Young Adults Study is supported by contracts HHSN268201800003I, HHSN268201800004I, HHSN268201800005I, HHSN268201800006I and HHSN268201800007I from the National Heart, Lung, and Blood Institute. Publisher Copyright: © © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

PY - 2020/3/8

Y1 - 2020/3/8

N2 - Objective: To evaluate the association of cigarette smoking and right ventricular (RV) systolic and diastolic functions in a population-based cohort of individuals at middle age.Methods: This cross-sectional study included participants who answered the smoking questionnaire and underwent echocardiography at the Coronary Artery Risk Development in Young Adulthood year 25 examination. RV systolic function was assessed by echocardiographic-derived tricuspid annular plane systolic excursion (TAPSE) and by right ventricular peak systolic velocity (RVS'), while RV diastolic function was evaluated by early right ventricular tissue velocity (RVE'). Multivariable linear regression models assessed the relationship of smoking with RV function, adjusting for age, sex, race, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes mellitus, alcohol consumption, pulmonary function, left ventricular systolic and diastolic function and coronary artery calcium score.Results: A total of 3424 participants were included. The mean age was 50±4 years; 57% were female; and 53% were black. There were 2106 (61%) never smokers, 750 (22%) former smokers and 589 (17%) current smokers. In the multivariable analysis, current smokers had significantly lower TAPSE (β=-0.082, SE=0.031, p=0.008), RVS' (β=-0.343, SE=0.156, p=0.028) and RVE' (β=-0.715, SE=0.195, p<0.001) compared with never smokers. Former smokers had a significantly lower RVE' compared with never smokers (β=-0.414, SE=0.162, p=0.011), whereas no significant difference in RV systolic function was found between former smokers and never smokers.Conclusions: In a large multicenter community-based biracial cohort of middle-aged individuals, smoking was independently related to both worse RV systolic and diastolic functions.

AB - Objective: To evaluate the association of cigarette smoking and right ventricular (RV) systolic and diastolic functions in a population-based cohort of individuals at middle age.Methods: This cross-sectional study included participants who answered the smoking questionnaire and underwent echocardiography at the Coronary Artery Risk Development in Young Adulthood year 25 examination. RV systolic function was assessed by echocardiographic-derived tricuspid annular plane systolic excursion (TAPSE) and by right ventricular peak systolic velocity (RVS'), while RV diastolic function was evaluated by early right ventricular tissue velocity (RVE'). Multivariable linear regression models assessed the relationship of smoking with RV function, adjusting for age, sex, race, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes mellitus, alcohol consumption, pulmonary function, left ventricular systolic and diastolic function and coronary artery calcium score.Results: A total of 3424 participants were included. The mean age was 50±4 years; 57% were female; and 53% were black. There were 2106 (61%) never smokers, 750 (22%) former smokers and 589 (17%) current smokers. In the multivariable analysis, current smokers had significantly lower TAPSE (β=-0.082, SE=0.031, p=0.008), RVS' (β=-0.343, SE=0.156, p=0.028) and RVE' (β=-0.715, SE=0.195, p<0.001) compared with never smokers. Former smokers had a significantly lower RVE' compared with never smokers (β=-0.414, SE=0.162, p=0.011), whereas no significant difference in RV systolic function was found between former smokers and never smokers.Conclusions: In a large multicenter community-based biracial cohort of middle-aged individuals, smoking was independently related to both worse RV systolic and diastolic functions.

KW - cardiac function

KW - echocardiography

KW - smoking

KW - Predictive Value of Tests

KW - Smokers

KW - Age Factors

KW - Cross-Sectional Studies

KW - Risk Assessment

KW - United States

KW - Humans

KW - Middle Aged

KW - Non-Smokers

KW - Risk Factors

KW - Male

KW - Smoking/adverse effects

KW - Ventricular Dysfunction, Right/diagnostic imaging

KW - Echocardiography, Doppler

KW - Female

KW - Ex-Smokers

KW - Ventricular Function, Right

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UR - http://www.scopus.com/inward/citedby.url?scp=85081637708&partnerID=8YFLogxK

U2 - 10.1136/openhrt-2020-001270

DO - 10.1136/openhrt-2020-001270

M3 - Article

C2 - 32201592

AN - SCOPUS:85081637708

SN - 2053-3624

VL - 7

JO - Open Heart

JF - Open Heart

IS - 1

M1 - e001270

ER -

Association of smoking and right ventricular function in middle age: CARDIA study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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