Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis

Faris A. Alshahrani; Firas K. Alqarawi; Montaser N. Alqutub; Abdulrahman M. Almubarak; Eman M. Alhamdan; Samar Al-Saleh; Paras Ahmad; Fahim Vohra; Tariq Abduljabbar

doi:10.3390/app11125559

Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis

Faris A. Alshahrani
, Firas K. Alqarawi
, Montaser N. Alqutub
, Abdulrahman M. Almubarak
, Eman M. Alhamdan
, Samar Al-Saleh
, Paras Ahmad
, Fahim Vohra
, Tariq Abduljabbar

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

To examine the association between self-perceived pain (SPP), clinical and radiographic peri-implant parameters, and biomarker levels among smokers and never smokers with and without peri-implantitis. Sixty individuals (20 smokers with peri-implantitis [group-1], 20 never smokers with peri-implantitis [group-2] and 20 never smokers without peri-implantitis [control-group]) were included. SPP was evaluated using a numeric pain rating scale (NPRS). Peri-implant plaque index (PI), probing depth (PD), and bleeding on probing (BOP) were recorded. After obtaining the samples, the levels of TNF-α, MMP-1, and IL-8 were measured. The mean SPP score in group-1, group-2, and the control group was 1.3 ± 1, 3.4 ± 1, and zero, respectively. The peri-implant mean PD (p < 0.05), BOP (p < 0.05), PI (p < 0.05), and crestal bone loss (CBL) (p < 0.05) were significantly higher among test groups than the control group. The levels of TNF-α, MMP-1, and IL-8 were significantly raised among group-1 and group-2 than the control group. A significant correlation between increasing SPP and PICF TNF-α, MMP-1, and IL-8 levels was observed based on regression analysis. Proinflammatory biomarkers were higher in smokers with peri-implantitis than never smokers with and without peri-implantitis, with a significant association between the proinflammatory cytokines and SPP.

Original language	English (US)
Article number	5559
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/app11125559
State	Published - Jun 2 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cigarette smoking
Cytokines
Inflammation
Pain
Peri-implant crevicular fluid
Peri-implantitis

Publisher link

10.3390/app11125559

Find It

Find It at U of M Libraries

Cite this

Alshahrani, F. A., Alqarawi, F. K., Alqutub, M. N., Almubarak, A. M., Alhamdan, E. M., Al-Saleh, S., Ahmad, P., Vohra, F., & Abduljabbar, T. (2021). Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis. Applied Sciences (Switzerland), 11(12), Article 5559. https://doi.org/10.3390/app11125559

Alshahrani, FA, Alqarawi, FK, Alqutub, MN, Almubarak, AM, Alhamdan, EM, Al-Saleh, S, Ahmad, P, Vohra, F & Abduljabbar, T 2021, 'Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis', Applied Sciences (Switzerland), vol. 11, no. 12, 5559. https://doi.org/10.3390/app11125559

@article{8a83f618650943d5ab09e56b5e6ffd93,

title = "Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis",

abstract = "To examine the association between self-perceived pain (SPP), clinical and radiographic peri-implant parameters, and biomarker levels among smokers and never smokers with and without peri-implantitis. Sixty individuals (20 smokers with peri-implantitis [group-1], 20 never smokers with peri-implantitis [group-2] and 20 never smokers without peri-implantitis [control-group]) were included. SPP was evaluated using a numeric pain rating scale (NPRS). Peri-implant plaque index (PI), probing depth (PD), and bleeding on probing (BOP) were recorded. After obtaining the samples, the levels of TNF-α, MMP-1, and IL-8 were measured. The mean SPP score in group-1, group-2, and the control group was 1.3 ± 1, 3.4 ± 1, and zero, respectively. The peri-implant mean PD (p < 0.05), BOP (p < 0.05), PI (p < 0.05), and crestal bone loss (CBL) (p < 0.05) were significantly higher among test groups than the control group. The levels of TNF-α, MMP-1, and IL-8 were significantly raised among group-1 and group-2 than the control group. A significant correlation between increasing SPP and PICF TNF-α, MMP-1, and IL-8 levels was observed based on regression analysis. Proinflammatory biomarkers were higher in smokers with peri-implantitis than never smokers with and without peri-implantitis, with a significant association between the proinflammatory cytokines and SPP.",

keywords = "Cigarette smoking, Cytokines, Inflammation, Pain, Peri-implant crevicular fluid, Peri-implantitis",

author = "Alshahrani, \{Faris A.\} and Alqarawi, \{Firas K.\} and Alqutub, \{Montaser N.\} and Almubarak, \{Abdulrahman M.\} and Alhamdan, \{Eman M.\} and Samar Al-Saleh and Paras Ahmad and Fahim Vohra and Tariq Abduljabbar",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jun,

day = "2",

doi = "10.3390/app11125559",

language = "English (US)",

volume = "11",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis

AU - Alshahrani, Faris A.

AU - Alqarawi, Firas K.

AU - Alqutub, Montaser N.

AU - Almubarak, Abdulrahman M.

AU - Alhamdan, Eman M.

AU - Al-Saleh, Samar

AU - Ahmad, Paras

AU - Vohra, Fahim

AU - Abduljabbar, Tariq

PY - 2021/6/2

Y1 - 2021/6/2

N2 - To examine the association between self-perceived pain (SPP), clinical and radiographic peri-implant parameters, and biomarker levels among smokers and never smokers with and without peri-implantitis. Sixty individuals (20 smokers with peri-implantitis [group-1], 20 never smokers with peri-implantitis [group-2] and 20 never smokers without peri-implantitis [control-group]) were included. SPP was evaluated using a numeric pain rating scale (NPRS). Peri-implant plaque index (PI), probing depth (PD), and bleeding on probing (BOP) were recorded. After obtaining the samples, the levels of TNF-α, MMP-1, and IL-8 were measured. The mean SPP score in group-1, group-2, and the control group was 1.3 ± 1, 3.4 ± 1, and zero, respectively. The peri-implant mean PD (p < 0.05), BOP (p < 0.05), PI (p < 0.05), and crestal bone loss (CBL) (p < 0.05) were significantly higher among test groups than the control group. The levels of TNF-α, MMP-1, and IL-8 were significantly raised among group-1 and group-2 than the control group. A significant correlation between increasing SPP and PICF TNF-α, MMP-1, and IL-8 levels was observed based on regression analysis. Proinflammatory biomarkers were higher in smokers with peri-implantitis than never smokers with and without peri-implantitis, with a significant association between the proinflammatory cytokines and SPP.

AB - To examine the association between self-perceived pain (SPP), clinical and radiographic peri-implant parameters, and biomarker levels among smokers and never smokers with and without peri-implantitis. Sixty individuals (20 smokers with peri-implantitis [group-1], 20 never smokers with peri-implantitis [group-2] and 20 never smokers without peri-implantitis [control-group]) were included. SPP was evaluated using a numeric pain rating scale (NPRS). Peri-implant plaque index (PI), probing depth (PD), and bleeding on probing (BOP) were recorded. After obtaining the samples, the levels of TNF-α, MMP-1, and IL-8 were measured. The mean SPP score in group-1, group-2, and the control group was 1.3 ± 1, 3.4 ± 1, and zero, respectively. The peri-implant mean PD (p < 0.05), BOP (p < 0.05), PI (p < 0.05), and crestal bone loss (CBL) (p < 0.05) were significantly higher among test groups than the control group. The levels of TNF-α, MMP-1, and IL-8 were significantly raised among group-1 and group-2 than the control group. A significant correlation between increasing SPP and PICF TNF-α, MMP-1, and IL-8 levels was observed based on regression analysis. Proinflammatory biomarkers were higher in smokers with peri-implantitis than never smokers with and without peri-implantitis, with a significant association between the proinflammatory cytokines and SPP.

KW - Cigarette smoking

KW - Cytokines

KW - Inflammation

KW - Pain

KW - Peri-implant crevicular fluid

KW - Peri-implantitis

UR - https://www.scopus.com/pages/publications/85108877734

UR - https://www.scopus.com/pages/publications/85108877734#tab=citedBy

U2 - 10.3390/app11125559

DO - 10.3390/app11125559

M3 - Article

AN - SCOPUS:85108877734

SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 12

M1 - 5559

ER -

Association of self-rated pain with clinical peri-implant parameters and cytokine profile in smokers and never smokers with and without peri-implantitis

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this