Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial

Marie Osdoit; Christina Yau; W. Fraser Symmans; Judy C. Boughey; Cheryl A. Ewing; Ron Balassanian; Yunn Yi Chen; Gregor Krings; Anne M. Wallace; Somaye Zare; Oluwole Fadare; Rachael Lancaster; Shi Wei; Constantine V. Godellas; Ping Tang; Todd M. Tuttle; Molly Klein; Sunati Sahoo; Tina J. Hieken; Jodi M. Carter; Beiyun Chen; Gretchen Ahrendt; Julia Tchou; Michael Feldman; Eleni Tousimis; Jay Zeck; Nora Jaskowiak; Husain Sattar; Arpana M. Naik; Marie Catherine Lee; Marilin Rosa; Laila Khazai; Mara H. Rendi; Julie E. Lang; Janice Lu; Ossama Tawfik; Smita M. Asare; Laura J. Esserman; Rita A. Mukhtar

doi:10.1001/jamasurg.2022.4118

Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial

Marie Osdoit, Christina Yau, W. Fraser Symmans, Judy C. Boughey, Cheryl A. Ewing, Ron Balassanian, Yunn Yi Chen, Gregor Krings, Anne M. Wallace, Somaye Zare, Oluwole Fadare, Rachael Lancaster, Shi Wei, Constantine V. Godellas, Ping Tang, Todd M. Tuttle, Molly Klein, Sunati Sahoo, Tina J. Hieken, Jodi M. CarterBeiyun Chen, Gretchen Ahrendt, Julia Tchou, Michael Feldman, Eleni Tousimis, Jay Zeck, Nora Jaskowiak, Husain Sattar, Arpana M. Naik, Marie Catherine Lee, Marilin Rosa, Laila Khazai, Mara H. Rendi, Julie E. Lang, Janice Lu, Ossama Tawfik, Smita M. Asare, Laura J. Esserman, Rita A. Mukhtar

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Importance: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer strongly correlates with overall survival and has become the standard end point in neoadjuvant trials. However, there is controversy regarding whether the definition of pCR should exclude or permit the presence of residual ductal carcinoma in situ (DCIS). Objective: To examine the association of residual DCIS in surgical specimens after neoadjuvant chemotherapy for breast cancer with survival end points to inform standards for the assessment of pathologic complete response. Design, Setting, and Participants: The study team analyzed the association of residual DCIS after NAC with 3-year event-free survival (EFS), distant recurrence-free survival (DRFS), and local-regional recurrence (LRR) in the I-SPY2 trial, an adaptive neoadjuvant platform trial for patients with breast cancer at high risk of recurrence. This is a retrospective analysis of clinical specimens and data from the ongoing I-SPY2 adaptive platform trial of novel therapeutics on a background of standard of care for early breast cancer. I-SPY2 participants are adult women diagnosed with stage II/III breast cancer at high risk of recurrence. Interventions: Participants were randomized to receive taxane and anthracycline-based neoadjuvant therapy with or without 1 of 10 investigational agents, followed by definitive surgery. Main Outcomes and Measures: The presence of DCIS and EFS, DRFS, and LRR. Results: The study team identified 933 I-SPY2 participants (aged 24 to 77 years) with complete pathology and follow-up data. Median follow-up time was 3.9 years; 337 participants (36%) had no residual invasive disease (residual cancer burden 0, or pCR). Of the 337 participants with pCR, 70 (21%) had residual DCIS, which varied significantly by tumor-receptor subtype; residual DCIS was present in 8.5% of triple negative tumors, 15.6% of hormone-receptor positive tumors, and 36.6% of ERBB2-positive tumors. Among those participants with pCR, there was no significant difference in EFS, DRFS, or LRR based on presence or absence of residual DCIS. Conclusions and Relevance: The analysis supports the definition of pCR as the absence of invasive disease after NAC regardless of the presence or absence of DCIS. Trial Registration: ClinicalTrials.gov Identifier NCT01042379..

Original language	English (US)
Pages (from-to)	1034-1041
Number of pages	8
Journal	JAMA Surgery
Volume	157
Issue number	11
DOIs	https://doi.org/10.1001/jamasurg.2022.4118
State	Published - Nov 9 2022

Bibliographical note

Funding Information:
grants from National Institutes of Health/National Cancer Institute and Quantum Leap Healthcare Collaborative, and nonfinancial support from Quantum Leap Healthcare Collaborative for San Antonio Breast Cancer Symposium registration and travel reimbursement during the conduct of the study. Dr Symmans reported founder shares from Delphi Diagnostics and grants from Pfizer for the pathology review for the NEOTALA trial outside the submitted work. In addition, Dr Symmans had a patent for a method of calculating residual cancer burden after neoadjuvant chemotherapy licensed to Delphi Diagnostics that is not related to this study but is indirectly relevant to the field of neoadjuvant chemotherapy. Dr Boughey reported grants from Quantum Leap funding for conduct of the clinical trial paid to their institution during the conduct of the study, grants from Eli Lilly research funding paid to their institution for clinical trial, fees from Cairns Surgical support for data and safety monitoring board time, and grants from SymBioSis to their institution, outside the submitted work. Dr Balassanian reported consultant fees from Genentech for patient education videos on reading pathology reports, outside the submitted work. Dr B. Chen reported grants from the Quantum Leap Healthcare Collaborative during the conduct of the study. Dr Rosa reported personal fees from Roche and AztraZeneca, outside the submitted work. Dr Lu reported compensation fees from Ambrx, outside the submitted work. Dr Esserman is on the board of directors and reported grants from Quantum Leap Healthcare, which provides financial support for the I-SPY TRIAL and grants from Merck during the conduct of the study. No other disclosures were reported.

Publisher Copyright:
© 2022 American Medical Association. All rights reserved.

PubMed: MeSH publication types

Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/jamasurg.2022.4118

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Osdoit, M., Yau, C., Symmans, W. F., Boughey, J. C., Ewing, C. A., Balassanian, R., Chen, Y. Y., Krings, G., Wallace, A. M., Zare, S., Fadare, O., Lancaster, R., Wei, S., Godellas, C. V., Tang, P., Tuttle, T. M., Klein, M., Sahoo, S., Hieken, T. J., ... Mukhtar, R. A. (2022). Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial. JAMA Surgery, 157(11), 1034-1041. https://doi.org/10.1001/jamasurg.2022.4118

Osdoit, M, Yau, C, Symmans, WF, Boughey, JC, Ewing, CA, Balassanian, R, Chen, YY, Krings, G, Wallace, AM, Zare, S, Fadare, O, Lancaster, R, Wei, S, Godellas, CV, Tang, P, Tuttle, TM , Klein, M, Sahoo, S, Hieken, TJ, Carter, JM, Chen, B, Ahrendt, G, Tchou, J, Feldman, M, Tousimis, E, Zeck, J, Jaskowiak, N, Sattar, H, Naik, AM, Lee, MC, Rosa, M, Khazai, L, Rendi, MH, Lang, JE, Lu, J, Tawfik, O, Asare, SM, Esserman, LJ & Mukhtar, RA 2022, 'Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial', JAMA Surgery, vol. 157, no. 11, pp. 1034-1041. https://doi.org/10.1001/jamasurg.2022.4118

@article{9ac0add609f948fcb43a0ccc657e1c0f,

title = "Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial",

abstract = "Importance: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer strongly correlates with overall survival and has become the standard end point in neoadjuvant trials. However, there is controversy regarding whether the definition of pCR should exclude or permit the presence of residual ductal carcinoma in situ (DCIS). Objective: To examine the association of residual DCIS in surgical specimens after neoadjuvant chemotherapy for breast cancer with survival end points to inform standards for the assessment of pathologic complete response. Design, Setting, and Participants: The study team analyzed the association of residual DCIS after NAC with 3-year event-free survival (EFS), distant recurrence-free survival (DRFS), and local-regional recurrence (LRR) in the I-SPY2 trial, an adaptive neoadjuvant platform trial for patients with breast cancer at high risk of recurrence. This is a retrospective analysis of clinical specimens and data from the ongoing I-SPY2 adaptive platform trial of novel therapeutics on a background of standard of care for early breast cancer. I-SPY2 participants are adult women diagnosed with stage II/III breast cancer at high risk of recurrence. Interventions: Participants were randomized to receive taxane and anthracycline-based neoadjuvant therapy with or without 1 of 10 investigational agents, followed by definitive surgery. Main Outcomes and Measures: The presence of DCIS and EFS, DRFS, and LRR. Results: The study team identified 933 I-SPY2 participants (aged 24 to 77 years) with complete pathology and follow-up data. Median follow-up time was 3.9 years; 337 participants (36%) had no residual invasive disease (residual cancer burden 0, or pCR). Of the 337 participants with pCR, 70 (21%) had residual DCIS, which varied significantly by tumor-receptor subtype; residual DCIS was present in 8.5% of triple negative tumors, 15.6% of hormone-receptor positive tumors, and 36.6% of ERBB2-positive tumors. Among those participants with pCR, there was no significant difference in EFS, DRFS, or LRR based on presence or absence of residual DCIS. Conclusions and Relevance: The analysis supports the definition of pCR as the absence of invasive disease after NAC regardless of the presence or absence of DCIS. Trial Registration: ClinicalTrials.gov Identifier NCT01042379..",

author = "Marie Osdoit and Christina Yau and Symmans, {W. Fraser} and Boughey, {Judy C.} and Ewing, {Cheryl A.} and Ron Balassanian and Chen, {Yunn Yi} and Gregor Krings and Wallace, {Anne M.} and Somaye Zare and Oluwole Fadare and Rachael Lancaster and Shi Wei and Godellas, {Constantine V.} and Ping Tang and Tuttle, {Todd M.} and Molly Klein and Sunati Sahoo and Hieken, {Tina J.} and Carter, {Jodi M.} and Beiyun Chen and Gretchen Ahrendt and Julia Tchou and Michael Feldman and Eleni Tousimis and Jay Zeck and Nora Jaskowiak and Husain Sattar and Naik, {Arpana M.} and Lee, {Marie Catherine} and Marilin Rosa and Laila Khazai and Rendi, {Mara H.} and Lang, {Julie E.} and Janice Lu and Ossama Tawfik and Asare, {Smita M.} and Esserman, {Laura J.} and Mukhtar, {Rita A.}",

note = "Funding Information: grants from National Institutes of Health/National Cancer Institute and Quantum Leap Healthcare Collaborative, and nonfinancial support from Quantum Leap Healthcare Collaborative for San Antonio Breast Cancer Symposium registration and travel reimbursement during the conduct of the study. Dr Symmans reported founder shares from Delphi Diagnostics and grants from Pfizer for the pathology review for the NEOTALA trial outside the submitted work. In addition, Dr Symmans had a patent for a method of calculating residual cancer burden after neoadjuvant chemotherapy licensed to Delphi Diagnostics that is not related to this study but is indirectly relevant to the field of neoadjuvant chemotherapy. Dr Boughey reported grants from Quantum Leap funding for conduct of the clinical trial paid to their institution during the conduct of the study, grants from Eli Lilly research funding paid to their institution for clinical trial, fees from Cairns Surgical support for data and safety monitoring board time, and grants from SymBioSis to their institution, outside the submitted work. Dr Balassanian reported consultant fees from Genentech for patient education videos on reading pathology reports, outside the submitted work. Dr B. Chen reported grants from the Quantum Leap Healthcare Collaborative during the conduct of the study. Dr Rosa reported personal fees from Roche and AztraZeneca, outside the submitted work. Dr Lu reported compensation fees from Ambrx, outside the submitted work. Dr Esserman is on the board of directors and reported grants from Quantum Leap Healthcare, which provides financial support for the I-SPY TRIAL and grants from Merck during the conduct of the study. No other disclosures were reported. Publisher Copyright: {\textcopyright} 2022 American Medical Association. All rights reserved.",

year = "2022",

month = nov,

day = "9",

doi = "10.1001/jamasurg.2022.4118",

language = "English (US)",

volume = "157",

pages = "1034--1041",

journal = "JAMA Surgery",

issn = "2168-6254",

publisher = "American Medical Association",

number = "11",

}

TY - JOUR

T1 - Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial

AU - Osdoit, Marie

AU - Yau, Christina

AU - Symmans, W. Fraser

AU - Boughey, Judy C.

AU - Ewing, Cheryl A.

AU - Balassanian, Ron

AU - Chen, Yunn Yi

AU - Krings, Gregor

AU - Wallace, Anne M.

AU - Zare, Somaye

AU - Fadare, Oluwole

AU - Lancaster, Rachael

AU - Wei, Shi

AU - Godellas, Constantine V.

AU - Tang, Ping

AU - Tuttle, Todd M.

AU - Klein, Molly

AU - Sahoo, Sunati

AU - Hieken, Tina J.

AU - Carter, Jodi M.

AU - Chen, Beiyun

AU - Ahrendt, Gretchen

AU - Tchou, Julia

AU - Feldman, Michael

AU - Tousimis, Eleni

AU - Zeck, Jay

AU - Jaskowiak, Nora

AU - Sattar, Husain

AU - Naik, Arpana M.

AU - Lee, Marie Catherine

AU - Rosa, Marilin

AU - Khazai, Laila

AU - Rendi, Mara H.

AU - Lang, Julie E.

AU - Lu, Janice

AU - Tawfik, Ossama

AU - Asare, Smita M.

AU - Esserman, Laura J.

AU - Mukhtar, Rita A.

N1 - Funding Information: grants from National Institutes of Health/National Cancer Institute and Quantum Leap Healthcare Collaborative, and nonfinancial support from Quantum Leap Healthcare Collaborative for San Antonio Breast Cancer Symposium registration and travel reimbursement during the conduct of the study. Dr Symmans reported founder shares from Delphi Diagnostics and grants from Pfizer for the pathology review for the NEOTALA trial outside the submitted work. In addition, Dr Symmans had a patent for a method of calculating residual cancer burden after neoadjuvant chemotherapy licensed to Delphi Diagnostics that is not related to this study but is indirectly relevant to the field of neoadjuvant chemotherapy. Dr Boughey reported grants from Quantum Leap funding for conduct of the clinical trial paid to their institution during the conduct of the study, grants from Eli Lilly research funding paid to their institution for clinical trial, fees from Cairns Surgical support for data and safety monitoring board time, and grants from SymBioSis to their institution, outside the submitted work. Dr Balassanian reported consultant fees from Genentech for patient education videos on reading pathology reports, outside the submitted work. Dr B. Chen reported grants from the Quantum Leap Healthcare Collaborative during the conduct of the study. Dr Rosa reported personal fees from Roche and AztraZeneca, outside the submitted work. Dr Lu reported compensation fees from Ambrx, outside the submitted work. Dr Esserman is on the board of directors and reported grants from Quantum Leap Healthcare, which provides financial support for the I-SPY TRIAL and grants from Merck during the conduct of the study. No other disclosures were reported. Publisher Copyright: © 2022 American Medical Association. All rights reserved.

PY - 2022/11/9

Y1 - 2022/11/9

N2 - Importance: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer strongly correlates with overall survival and has become the standard end point in neoadjuvant trials. However, there is controversy regarding whether the definition of pCR should exclude or permit the presence of residual ductal carcinoma in situ (DCIS). Objective: To examine the association of residual DCIS in surgical specimens after neoadjuvant chemotherapy for breast cancer with survival end points to inform standards for the assessment of pathologic complete response. Design, Setting, and Participants: The study team analyzed the association of residual DCIS after NAC with 3-year event-free survival (EFS), distant recurrence-free survival (DRFS), and local-regional recurrence (LRR) in the I-SPY2 trial, an adaptive neoadjuvant platform trial for patients with breast cancer at high risk of recurrence. This is a retrospective analysis of clinical specimens and data from the ongoing I-SPY2 adaptive platform trial of novel therapeutics on a background of standard of care for early breast cancer. I-SPY2 participants are adult women diagnosed with stage II/III breast cancer at high risk of recurrence. Interventions: Participants were randomized to receive taxane and anthracycline-based neoadjuvant therapy with or without 1 of 10 investigational agents, followed by definitive surgery. Main Outcomes and Measures: The presence of DCIS and EFS, DRFS, and LRR. Results: The study team identified 933 I-SPY2 participants (aged 24 to 77 years) with complete pathology and follow-up data. Median follow-up time was 3.9 years; 337 participants (36%) had no residual invasive disease (residual cancer burden 0, or pCR). Of the 337 participants with pCR, 70 (21%) had residual DCIS, which varied significantly by tumor-receptor subtype; residual DCIS was present in 8.5% of triple negative tumors, 15.6% of hormone-receptor positive tumors, and 36.6% of ERBB2-positive tumors. Among those participants with pCR, there was no significant difference in EFS, DRFS, or LRR based on presence or absence of residual DCIS. Conclusions and Relevance: The analysis supports the definition of pCR as the absence of invasive disease after NAC regardless of the presence or absence of DCIS. Trial Registration: ClinicalTrials.gov Identifier NCT01042379..

AB - Importance: Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer strongly correlates with overall survival and has become the standard end point in neoadjuvant trials. However, there is controversy regarding whether the definition of pCR should exclude or permit the presence of residual ductal carcinoma in situ (DCIS). Objective: To examine the association of residual DCIS in surgical specimens after neoadjuvant chemotherapy for breast cancer with survival end points to inform standards for the assessment of pathologic complete response. Design, Setting, and Participants: The study team analyzed the association of residual DCIS after NAC with 3-year event-free survival (EFS), distant recurrence-free survival (DRFS), and local-regional recurrence (LRR) in the I-SPY2 trial, an adaptive neoadjuvant platform trial for patients with breast cancer at high risk of recurrence. This is a retrospective analysis of clinical specimens and data from the ongoing I-SPY2 adaptive platform trial of novel therapeutics on a background of standard of care for early breast cancer. I-SPY2 participants are adult women diagnosed with stage II/III breast cancer at high risk of recurrence. Interventions: Participants were randomized to receive taxane and anthracycline-based neoadjuvant therapy with or without 1 of 10 investigational agents, followed by definitive surgery. Main Outcomes and Measures: The presence of DCIS and EFS, DRFS, and LRR. Results: The study team identified 933 I-SPY2 participants (aged 24 to 77 years) with complete pathology and follow-up data. Median follow-up time was 3.9 years; 337 participants (36%) had no residual invasive disease (residual cancer burden 0, or pCR). Of the 337 participants with pCR, 70 (21%) had residual DCIS, which varied significantly by tumor-receptor subtype; residual DCIS was present in 8.5% of triple negative tumors, 15.6% of hormone-receptor positive tumors, and 36.6% of ERBB2-positive tumors. Among those participants with pCR, there was no significant difference in EFS, DRFS, or LRR based on presence or absence of residual DCIS. Conclusions and Relevance: The analysis supports the definition of pCR as the absence of invasive disease after NAC regardless of the presence or absence of DCIS. Trial Registration: ClinicalTrials.gov Identifier NCT01042379..

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ER -

Association of Residual Ductal Carcinoma in Situ with Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial

Abstract

Bibliographical note

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UN SDGs

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