Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Laura D. Carbone; Petra Bůžková; Howard A. Fink; John A. Robbins; Monique Bethel; Mark W. Hamrick; William D. Hill

doi:10.1007/s00223-017-0245-8

Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Laura D. Carbone, Petra Bůžková, Howard A. Fink, John A. Robbins, Monique Bethel, Mark W. Hamrick, William D. Hill

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.

Original language	English (US)
Pages (from-to)	599-608
Number of pages	10
Journal	Calcified Tissue International
Volume	100
Issue number	6
DOIs	https://doi.org/10.1007/s00223-017-0245-8
State	Published - Jun 1 2017

Bibliographical note

Funding Information:
This work was supported by contracts and awards to the Cardiovascular Health Study (CHS) from the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS) including contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC55222N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086, and grants HL094555 and 080295; additional support provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. Additional support was provided by P01AG036675 from the NIA (WDH/MWH), the Augusta University Pilot Study Research Program (WDH/LC), and by 1I01CX000930 from the Department of Veterans Affairs (WDH). The contents of this publication do not represent the views of the Department of Veterans Affairs or the United States Government. LDC: conceiving and designing the study, interpretation of the data, and drafting of the manuscript. PB: statistical analyses and critical review of the manuscript. HAF: critical review of the manuscript, designing the study, and interpretation of the data. JAR: designing the study, interpretation of the data, critical review of the manuscript, and funding support. MB: interpretation of the data and critical review of the manuscript. MWH: critical review of the manuscript and interpretation of data. WDH: conceiving and designing the study, interpretation of the data, performance of SDF-1 laboratory measurements, and critical review of the manuscript.

Publisher Copyright:
© 2017, Springer Science+Business Media New York.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

Aging
Body composition
Cytokines
DXA
Epidemiology
Osteoporosis

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10.1007/s00223-017-0245-8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649737

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Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults : The Cardiovascular Health Study. / Carbone, Laura D.; Bůžková, Petra; Fink, Howard A.; Robbins, John A.; Bethel, Monique; Hamrick, Mark W.; Hill, William D.

In: Calcified Tissue International, Vol. 100, No. 6, 01.06.2017, p. 599-608.

Research output: Contribution to journal › Article › peer-review

@article{ac38235d8bcd451d9231ba4e0cd50793,

title = "Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study",

abstract = "Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.",

keywords = "Aging, Body composition, Cytokines, DXA, Epidemiology, Osteoporosis",

author = "Carbone, {Laura D.} and Petra Bů{\v z}kov{\'a} and Fink, {Howard A.} and Robbins, {John A.} and Monique Bethel and Hamrick, {Mark W.} and Hill, {William D.}",

note = "Funding Information: This work was supported by contracts and awards to the Cardiovascular Health Study (CHS) from the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS) including contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC55222N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086, and grants HL094555 and 080295; additional support provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. Additional support was provided by P01AG036675 from the NIA (WDH/MWH), the Augusta University Pilot Study Research Program (WDH/LC), and by 1I01CX000930 from the Department of Veterans Affairs (WDH). The contents of this publication do not represent the views of the Department of Veterans Affairs or the United States Government. LDC: conceiving and designing the study, interpretation of the data, and drafting of the manuscript. PB: statistical analyses and critical review of the manuscript. HAF: critical review of the manuscript, designing the study, and interpretation of the data. JAR: designing the study, interpretation of the data, critical review of the manuscript, and funding support. MB: interpretation of the data and critical review of the manuscript. MWH: critical review of the manuscript and interpretation of data. WDH: conceiving and designing the study, interpretation of the data, performance of SDF-1 laboratory measurements, and critical review of the manuscript. Publisher Copyright: {\textcopyright} 2017, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

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doi = "10.1007/s00223-017-0245-8",

language = "English (US)",

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AU - Carbone, Laura D.

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AU - Fink, Howard A.

AU - Robbins, John A.

AU - Bethel, Monique

AU - Hamrick, Mark W.

AU - Hill, William D.

N1 - Funding Information: This work was supported by contracts and awards to the Cardiovascular Health Study (CHS) from the National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS) including contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC55222N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086, and grants HL094555 and 080295; additional support provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. Additional support was provided by P01AG036675 from the NIA (WDH/MWH), the Augusta University Pilot Study Research Program (WDH/LC), and by 1I01CX000930 from the Department of Veterans Affairs (WDH). The contents of this publication do not represent the views of the Department of Veterans Affairs or the United States Government. LDC: conceiving and designing the study, interpretation of the data, and drafting of the manuscript. PB: statistical analyses and critical review of the manuscript. HAF: critical review of the manuscript, designing the study, and interpretation of the data. JAR: designing the study, interpretation of the data, critical review of the manuscript, and funding support. MB: interpretation of the data and critical review of the manuscript. MWH: critical review of the manuscript and interpretation of data. WDH: conceiving and designing the study, interpretation of the data, performance of SDF-1 laboratory measurements, and critical review of the manuscript. Publisher Copyright: © 2017, Springer Science+Business Media New York. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

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N2 - Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.

AB - Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone formation and BMSC differentiation into osteoblasts/osteocytes, and in osteoprogenitor cell survival. The objective of this study was to examine the association of plasma SDF-1 in participants in the cardiovascular health study (CHS) with bone mineral density (BMD), body composition, and incident hip fractures. In 1536 CHS participants, SDF-1 plasma levels were significantly associated with increasing age (p < 0.01) and male gender (p = 0.04), but not with race (p = 0.63). In multivariable-adjusted models, higher SDF-1 levels were associated with lower total hip BMD (p = 0.02). However, there was no significant association of SDF-1 with hip fractures (p = 0.53). In summary, circulating plasma levels of SDF-1 are associated with increasing age and independently associated with lower total hip BMD in both men and women. These findings suggest that SDF-1 levels are linked to bone homeostasis.

KW - Aging

KW - Body composition

KW - Cytokines

KW - DXA

KW - Epidemiology

KW - Osteoporosis

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Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study

Abstract

Bibliographical note

Keywords

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