Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling: The cardia study (Coronary Artery Risk Development inYoung Adults).

Satoru Kishi; Anderson C. Armstrong; Samuel S. Gidding; Laura A. Colangelo; Bharath A. Venkatesh; David R. Jacobs; J. Jeffery Carr; James G. Terry; Kiang Liu; David C. Goff; João A.C. Lima

doi:10.1016/j.jchf.2014.03.001

Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling: The cardia study (Coronary Artery Risk Development inYoung Adults).

Satoru Kishi, Anderson C. Armstrong, Samuel S. Gidding, Laura A. Colangelo, Bharath A. Venkatesh, David R. Jacobs, J. Jeffery Carr, James G. Terry, Kiang Liu, David C. Goff, João A.C. Lima

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Objectives: The goal of this study was to investigate the relationship of body mass index (BMI) and its 25-year changeto left ventricular (LV) structure and function. Background: Longstanding obesity may be associated with clinical cardiac dysfunction and heart failure. Whether obesity relates to cardiac dysfunction during young adulthood and middle age has not been investigated. Methods: The CARDIA (Coronary Artery Risk Development in Young Adult) study enrolled white and black adults ages 18 to 30 years in 1985 to 1986 (Year-0). At Year-25, cardiac function was assessed by conventional echocardiography, tissue Doppler imaging (TDI), and speckle tracking echocardiography (STE). Twenty-five-year change in BMI (classified as low:<27 kg/m² and high:≥27 kg/m²) was categorized into 4 groups (Low-Low, High-Low, Low-High, and High-High). Multiple linear regression was used to quantify the association between categorical changes in BMI (Low-Low as reference) with LV structural and functional parameters obtained in middle age, adjusting for baseline and 25-year change in risk factors. Results: The mean BMI was 24.4 kg/m² in 3,265 participants included at Year-0. Change in BMI adjusted for risk factors was directly associated with incipient myocardial systolic dysfunction assessed by STE (High-High: β-coefficient= 0.67; Low-High: β-coefficient= 0.35 for longitudinal peak systolic strain) and diastolic dysfunction assessed by TDI (High-High: β-coefficient=-074; Low-High: β-coefficient=-0.45 for e') and STE (High-High: β-coefficient=-0.06 for circumferential early diastolic strain rate). Greater BMI was also significantly associated with increased LV mass/height (High-High: β-coefficient= 26.11; Low-High: β-coefficient= 11.87). Conclusions: Longstanding obesity from young adulthood to middle age is associated with impaired LV systolic anddiastolic function assessed by conventional echocardiography, TDI, and STE in a large biracial cohort of adults age43to 55years.

Original language	English (US)
Pages (from-to)	500-508
Number of pages	9
Journal	JACC: Heart Failure
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/j.jchf.2014.03.001
State	Published - Oct 1 2014

Bibliographical note

Funding Information:
The CARDIA study was conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C and HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). The CARDIA study is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). The manuscript of this paper was reviewed by CARDIA for scientific content. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2014 American College of Cardiology Foundation.

Keywords

Echocardiography
Left ventricular function
Left ventricular remodeling
Obesity
Risk factors
Speckle tracking echocardiography
Tissue doppler imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jchf.2014.03.001

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Kishi, S., Armstrong, A. C., Gidding, S. S., Colangelo, L. A., Venkatesh, B. A., Jacobs, D. R., Carr, J. J., Terry, J. G., Liu, K., Goff, D. C., & Lima, J. A. C. (2014). Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling: The cardia study (Coronary Artery Risk Development inYoung Adults). JACC: Heart Failure, 2(5), 500-508. https://doi.org/10.1016/j.jchf.2014.03.001

Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling : The cardia study (Coronary Artery Risk Development inYoung Adults). / Kishi, Satoru; Armstrong, Anderson C.; Gidding, Samuel S. et al.

In: JACC: Heart Failure, Vol. 2, No. 5, 01.10.2014, p. 500-508.

Research output: Contribution to journal › Article › peer-review

Kishi, S, Armstrong, AC, Gidding, SS, Colangelo, LA, Venkatesh, BA, Jacobs, DR, Carr, JJ, Terry, JG, Liu, K, Goff, DC & Lima, JAC 2014, 'Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling: The cardia study (Coronary Artery Risk Development inYoung Adults).', JACC: Heart Failure, vol. 2, no. 5, pp. 500-508. https://doi.org/10.1016/j.jchf.2014.03.001

@article{1b90a3e9bae04b64bcf1114e1a640f2c,

title = "Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling: The cardia study (Coronary Artery Risk Development inYoung Adults).",

abstract = "Objectives: The goal of this study was to investigate the relationship of body mass index (BMI) and its 25-year changeto left ventricular (LV) structure and function. Background: Longstanding obesity may be associated with clinical cardiac dysfunction and heart failure. Whether obesity relates to cardiac dysfunction during young adulthood and middle age has not been investigated. Methods: The CARDIA (Coronary Artery Risk Development in Young Adult) study enrolled white and black adults ages 18 to 30 years in 1985 to 1986 (Year-0). At Year-25, cardiac function was assessed by conventional echocardiography, tissue Doppler imaging (TDI), and speckle tracking echocardiography (STE). Twenty-five-year change in BMI (classified as low:<27 kg/m2 and high:≥27 kg/m2) was categorized into 4 groups (Low-Low, High-Low, Low-High, and High-High). Multiple linear regression was used to quantify the association between categorical changes in BMI (Low-Low as reference) with LV structural and functional parameters obtained in middle age, adjusting for baseline and 25-year change in risk factors. Results: The mean BMI was 24.4 kg/m2 in 3,265 participants included at Year-0. Change in BMI adjusted for risk factors was directly associated with incipient myocardial systolic dysfunction assessed by STE (High-High: β-coefficient= 0.67; Low-High: β-coefficient= 0.35 for longitudinal peak systolic strain) and diastolic dysfunction assessed by TDI (High-High: β-coefficient=-074; Low-High: β-coefficient=-0.45 for e') and STE (High-High: β-coefficient=-0.06 for circumferential early diastolic strain rate). Greater BMI was also significantly associated with increased LV mass/height (High-High: β-coefficient= 26.11; Low-High: β-coefficient= 11.87). Conclusions: Longstanding obesity from young adulthood to middle age is associated with impaired LV systolic anddiastolic function assessed by conventional echocardiography, TDI, and STE in a large biracial cohort of adults age43to 55years.",

keywords = "Echocardiography, Left ventricular function, Left ventricular remodeling, Obesity, Risk factors, Speckle tracking echocardiography, Tissue doppler imaging",

author = "Satoru Kishi and Armstrong, {Anderson C.} and Gidding, {Samuel S.} and Colangelo, {Laura A.} and Venkatesh, {Bharath A.} and Jacobs, {David R.} and Carr, {J. Jeffery} and Terry, {James G.} and Kiang Liu and Goff, {David C.} and Lima, {Jo{\~a}o A.C.}",

note = "Funding Information: The CARDIA study was conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C and HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). The CARDIA study is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). The manuscript of this paper was reviewed by CARDIA for scientific content. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2014 American College of Cardiology Foundation.",

year = "2014",

month = oct,

day = "1",

doi = "10.1016/j.jchf.2014.03.001",

language = "English (US)",

volume = "2",

pages = "500--508",

journal = "JACC: Heart Failure",

issn = "2213-1779",

publisher = "Elsevier BV",

number = "5",

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TY - JOUR

T1 - Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling

T2 - The cardia study (Coronary Artery Risk Development inYoung Adults).

AU - Kishi, Satoru

AU - Armstrong, Anderson C.

AU - Gidding, Samuel S.

AU - Colangelo, Laura A.

AU - Venkatesh, Bharath A.

AU - Jacobs, David R.

AU - Carr, J. Jeffery

AU - Terry, James G.

AU - Liu, Kiang

AU - Goff, David C.

AU - Lima, João A.C.

N1 - Funding Information: The CARDIA study was conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C and HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). The CARDIA study is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). The manuscript of this paper was reviewed by CARDIA for scientific content. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: © 2014 American College of Cardiology Foundation.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objectives: The goal of this study was to investigate the relationship of body mass index (BMI) and its 25-year changeto left ventricular (LV) structure and function. Background: Longstanding obesity may be associated with clinical cardiac dysfunction and heart failure. Whether obesity relates to cardiac dysfunction during young adulthood and middle age has not been investigated. Methods: The CARDIA (Coronary Artery Risk Development in Young Adult) study enrolled white and black adults ages 18 to 30 years in 1985 to 1986 (Year-0). At Year-25, cardiac function was assessed by conventional echocardiography, tissue Doppler imaging (TDI), and speckle tracking echocardiography (STE). Twenty-five-year change in BMI (classified as low:<27 kg/m2 and high:≥27 kg/m2) was categorized into 4 groups (Low-Low, High-Low, Low-High, and High-High). Multiple linear regression was used to quantify the association between categorical changes in BMI (Low-Low as reference) with LV structural and functional parameters obtained in middle age, adjusting for baseline and 25-year change in risk factors. Results: The mean BMI was 24.4 kg/m2 in 3,265 participants included at Year-0. Change in BMI adjusted for risk factors was directly associated with incipient myocardial systolic dysfunction assessed by STE (High-High: β-coefficient= 0.67; Low-High: β-coefficient= 0.35 for longitudinal peak systolic strain) and diastolic dysfunction assessed by TDI (High-High: β-coefficient=-074; Low-High: β-coefficient=-0.45 for e') and STE (High-High: β-coefficient=-0.06 for circumferential early diastolic strain rate). Greater BMI was also significantly associated with increased LV mass/height (High-High: β-coefficient= 26.11; Low-High: β-coefficient= 11.87). Conclusions: Longstanding obesity from young adulthood to middle age is associated with impaired LV systolic anddiastolic function assessed by conventional echocardiography, TDI, and STE in a large biracial cohort of adults age43to 55years.

AB - Objectives: The goal of this study was to investigate the relationship of body mass index (BMI) and its 25-year changeto left ventricular (LV) structure and function. Background: Longstanding obesity may be associated with clinical cardiac dysfunction and heart failure. Whether obesity relates to cardiac dysfunction during young adulthood and middle age has not been investigated. Methods: The CARDIA (Coronary Artery Risk Development in Young Adult) study enrolled white and black adults ages 18 to 30 years in 1985 to 1986 (Year-0). At Year-25, cardiac function was assessed by conventional echocardiography, tissue Doppler imaging (TDI), and speckle tracking echocardiography (STE). Twenty-five-year change in BMI (classified as low:<27 kg/m2 and high:≥27 kg/m2) was categorized into 4 groups (Low-Low, High-Low, Low-High, and High-High). Multiple linear regression was used to quantify the association between categorical changes in BMI (Low-Low as reference) with LV structural and functional parameters obtained in middle age, adjusting for baseline and 25-year change in risk factors. Results: The mean BMI was 24.4 kg/m2 in 3,265 participants included at Year-0. Change in BMI adjusted for risk factors was directly associated with incipient myocardial systolic dysfunction assessed by STE (High-High: β-coefficient= 0.67; Low-High: β-coefficient= 0.35 for longitudinal peak systolic strain) and diastolic dysfunction assessed by TDI (High-High: β-coefficient=-074; Low-High: β-coefficient=-0.45 for e') and STE (High-High: β-coefficient=-0.06 for circumferential early diastolic strain rate). Greater BMI was also significantly associated with increased LV mass/height (High-High: β-coefficient= 26.11; Low-High: β-coefficient= 11.87). Conclusions: Longstanding obesity from young adulthood to middle age is associated with impaired LV systolic anddiastolic function assessed by conventional echocardiography, TDI, and STE in a large biracial cohort of adults age43to 55years.

KW - Echocardiography

KW - Left ventricular function

KW - Left ventricular remodeling

KW - Obesity

KW - Risk factors

KW - Speckle tracking echocardiography

KW - Tissue doppler imaging

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Association of obesity in early adulthoodand middle age with incipientleft ventricular dysfunction andstructural remodeling: The cardia study (Coronary Artery Risk Development inYoung Adults).

Abstract

Bibliographical note

Keywords

UN SDGs

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