Association of Melanocortin-1 Receptor Variants with Pigmentary Traits in Humans: A Pooled Analysis from the M-Skip Project

Elena Tagliabue, Sara Gandini, Patrick Maisonneuve, Sara Raimondi, José C. García-Borrón, Julia Newton-Bishop, David Polsky, De Ann Lazovich, Rajiv Kumar, Paola Ghiorzo, Paola Ghiorzo, Leah Ferrucci, Nelleke A. Gruis, Susana Puig, Peter A. Kanetsky, Tomonori Motokawa, Gloria Ribas, Maria Teresa Landi, Maria Concetta Fargnoli, Terence H. WongAlexander Stratigos, Per Helsing, Gabriella Guida, Philippe Autier, Jiali Han, Julian Little, Francesco Sera, Sara Raimondi, Philippe Autier, Maria Concetta Fargnoli, José C. García-Borrón, Jiali Han, Peter A. Kanetsky, Maria Teresa Landi, Julian Little, Julia Newton-Bishop, Francesco Sera, Saverio Caini, Sara Gandini, Patrick Maisonneuve, Albert Hofman, Manfred Kayser, Fan Liu, Tamar Nijsten, Andre G. Uitterlinden, Rajiv Kumar, Dominique Scherer, Tim Bishop, Julia Newton-Bishop, Faye Elliott, Eduardo Nagore, David Polsky, Johan Hansson, Veronica Hoiom, Paola Ghiorzo, Lorenza Pastorino, Nelleke A. Gruis, Jan Nico Bouwes Bavinck, Paula Aguilera, Celia Badenas, Cristina Carrera, Pol Gimenez-Xavier, Josep Malvehy, Miriam Potrony, Susana Puig, Joan Anton Puig-Butille, Gemma Tell-Marti, Terence Dwyer, Leigh Blizzard, Jennifer Cochrane, Ricardo Fernandez-de-Misa, Wojciech Branicki, Tadeusz Debniak, Niels Morling, Peter Johansen, Susan Mayne, Allen Bale, Brenda Cartmel, Leah Ferrucci, Ruth Pfeiffer, Giuseppe Palmieri, Gloria Ribas, Chiara Menin, Alexander Stratigos, Katerina Kypreou, Anne Bowcock, Lynn Cornelius, M. Laurin Council, Tomonori Motokawa, Sumiko Anno, Per Helsing, Per Arne Andresen, Gabriella Guida, Stefania Guida, Terence H. Wong

Research output: Contribution to journalArticlepeer-review

14 Scopus citations
Original languageEnglish (US)
Pages (from-to)1914-1917
Number of pages4
JournalJournal of Investigative Dermatology
Volume136
Issue number9
DOIs
StatePublished - Sep 1 2016

Bibliographical note

Funding Information:
This work was supported by the Italian Association for Cancer Research (grant number: MFAG 11831). The Melanoma Susceptibility Study (PAK) was supported by the National Cancer Institute [CA75434, CA80700, and CA092428]. The Nurses’ Health Study and the Health Professionals Follow-Up Study (JH) were supported by NIH R01 CA49449, P01 CA87969, UM1 CA186107, and UM1 CA167552. We would like to thank the participants and staff of the Nurses’ Health Study, the Health Professionals Follow-Up Study for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. Genoa study was supported by AIRC IG 15460 to PG. The M-SKIP study group consists of the following members: Principal Investigator (PI): Sara Raimondi (European Institute of Oncology, Milan, Italy); Advisory Committee members: Philippe Autier (International Prevention Research Institute, Lyon, France), Maria Concetta Fargnoli (University of L'Aquila, Italy), José C. García-Borrón (University of Murcia, Spain), Jiali Han (Brigham and Women’s Hospital and Harvard Medical School, Boston, MA), Peter A. Kanetsky (Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL), Maria Teresa Landi (National Cancer Institute, NIH, Bethesda, MD), Julian Little (University of Ottawa, Canada), Julia Newton-Bishop (University of Leeds, UK), Francesco Sera (UCL Institute of Child Health, London, UK); Consultants: Saverio Caini (ISPO, Florence, Italy), Sara Gandini and Patrick Maisonneuve (European Institute of Oncology, Milan, Italy); Participant Investigators: Albert Hofman, Manfred Kayser, Fan Liu, Tamar Nijsten, and Andre G. Uitterlinden (Erasmus MC University Medical Center, Rotterdam, The Netherlands), Rajiv Kumar and Dominique Scherer (German Cancer Research Center, Heidelberg, Germany), Tim Bishop, Julia Newton-Bishop, and Faye Elliott (University of Leeds, UK), Eduardo Nagore (Instituto Valenciano de Oncologia, Valencia, Spain), DeAnn Lazovich (Division of Epidemiology and Community Health, University of Minnesota, MN), David Polsky (New York University School of Medicine, New York, NY), Johan Hansson and Veronica Hoiom (Karolinska Institutet, Stockholm, Sweden), Paola Ghiorzo and Lorenza Pastorino (University of Genoa, Italy), Nelleke A. Gruis and Jan Nico Bouwes Bavinck (Leiden University Medical Center, The Netherlands), Paula Aguilera, Celia Badenas, Cristina Carrera, Pol Gimenez-Xavier, Josep Malvehy, Miriam Potrony, Susana Puig, Joan Anton Puig-Butille, Gemma Tell-Marti (Hospital Clinic, IDIBAPS and CIBERER, Barcelona, Spain), Terence Dwyer (Murdoch Childrens Research Institute, Victoria, Australia), Leigh Blizzard and Jennifer Cochrane (Menzies Institute for Medical Research, Hobart, Australia), Ricardo Fernandez-de-Misa (Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain), Wojciech Branicki (Institute of Forensic Research, Krakow, Poland), Tadeusz Debniak (Pomeranian Medical University, Polabska, Poland), Niels Morling and Peter Johansen (University of Copenhagen, Denmark), Susan Mayne, Allen Bale, Brenda Cartmel and Leah Ferrucci (Yale School of Public Health and Medicine, New Haven, CT), Ruth Pfeiffer (National Cancer Institute, NIH, Bethesda, MD), Giuseppe Palmieri (Istituto di Chimica Biomolecolare, CNR, Sassari, Italy), Gloria Ribas (Fundación Investigación Clínico de Valencia Instituto de Investigación Sanitaria- INCLIVA, Spain), Chiara Menin (Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy), Alexander Stratigos and Katerina Kypreou (University of Athens, Andreas Sygros Hospital, Athens, Greece), Anne Bowcock, Lynn Cornelius, and M. Laurin Council (Washington University School of Medicine, St. Louis, MO), Tomonori Motokawa (POLA Chemical Industries, Yokohama, Japan), Sumiko Anno (Shibaura Institute of Technology, Tokyo, Japan), Per Helsing and Per Arne Andresen (Oslo University Hospital, Norway), Gabriella Guida and Stefania Guida (University of Bari, Bari, Italy), Terence H. Wong (University of Edinburgh, UK), and the GEM Study Group. Participants in the GEM Study Group are as follows: Coordinating Center, Memorial Sloan-Kettering Cancer Center, New York, NY: Marianne Berwick (PI, currently at the University of New Mexico), Colin Begg (Co-PI), Irene Orlow (Co-Investigator), Urvi Mujumdar (Project Coordinator), Amanda Hummer (Biostatistician), Klaus Busam (Dermatopathologist), Pampa Roy (Laboratory Technician), Rebecca Canchola (Laboratory Technician), Brian Clas (Laboratory Technician), Javiar Cotignola (Laboratory Technician), Yvette Monroe (Interviewer). Study Centers: The University of Sydney and The Cancer Council New South Wales, Sydney (Australia): Bruce Armstrong (PI), Anne Kricker (co-PI), Melisa Litchfield (Study Coordinator). Menzies Institute for Medical Research, University of Tasmania, Hobart (Australia): Terence Dwyer (PI), Paul Tucker (Dermatopathologist), Nicola Stephens (Study Coordinator). British Columbia Cancer Agency, Vancouver (Canada): Richard Gallagher (PI), Teresa Switzer (Coordinator). Cancer Care Ontario, Toronto (Canada): Loraine Marrett (PI), Beth Theis (Co-Investigator), Lynn From (Dermatopathologist), Noori Chowdhury (Coordinator), Louise Vanasse (Coordinator), Mark Purdue (Research Officer). David Northrup (Manager for CATI). Centro per la Prevenzione Oncologia Torino, Piemonte (Italy): Roberto Zanetti (PI), Stefano Rosso (Data Manager), Carlotta Sacerdote (Coordinator). University of California, Irvine, CA: Hoda Anton-Culver (PI), Nancy Leighton (Coordinator), Maureen Gildea (Data Manager). University of Michigan, Ann Arbor, MI: Stephen Gruber (PI), Joe Bonner (Data Manager), Joanne Jeter (Coordinator). New Jersey Department of Health and Senior Services, Trenton, NJ: Judith Klotz (PI), Homer Wilcox (Co-PI), Helen Weiss (Coordinator). University of North Carolina, Chapel Hill, NC: Robert Millikan (PI), Nancy Thomas (Co-Investigator), Dianne Mattingly (Coordinator), Jon Player (Laboratory Technician), Chiu-Kit Tse (Data Analyst). University of Pennsylvania, Philadelphia, PA: Timothy Rebbeck (PI), Peter Kanetsky (Co-Investigator), Amy Walker (Laboratory Technician), Saarene Panossian (Laboratory Technician). Consultants: Harvey Mohrenweiser, University of California, Irvine, Irvine, CA; Richard Setlow, Brookhaven National Laboratory, Upton, NY.

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