Association of Longitudinal Changes in NT-proBNP with Changes in Left Atrial Volume and Function: MESA

Vinithra Varadarajan, Bharath Ambale-Venkatesh, Seo Young Hong, Mohammadali Habibi, Hiroshi Ashikaga, Colin O. Wu, Lin Y. Chen, Susan R. Heckbert, David A. Bluemke, Joao A.C. Lima

Research output: Contribution to journalArticle

4 Scopus citations


Background: The mechanism of left atrial (LA) remodeling is poorly understood. The aim of this longitudinal study was to investigate whether changes in NT-proBNP levels relate to alterations of LA structure and function over time in a multiethnic population. Methods: From the prospective cohort study, the Multi-Ethnic Study of Atherosclerosis, our analysis included 1,838 participants who underwent cardiac magnetic resonance imaging at the baseline and 10-year examinations, had NT-proBNP levels available at both time points, and did not develop heart failure, myocardial infarction, and/or atrial fibrillation. Multivariable linear regression was used to analyze the association between NT-proBNP level (log-transformed) at the 2 time points and change in LA volumes, LA emptying fractions (total, active, and passive), and LA longitudinal strain. Log NT-proBNP was categorized into Low-Low (N = 681), Low-High (N = 238), High-Low (N = 237), and High-High (N = 682) based on the median value at both time points. Results: With the Low-Low group as the reference group, the High-High group experienced a greater increase in LA maximum and minimum indexed volumes: 3.1 ml/m2 (95% confidence interval 1.98, 4.20) and 2.7 ml/m2 (1.89, 3.51), respectively. The High-High group also experienced a greater decrease in LA total, passive, active emptying fraction, and longitudinal strain: -3.3% (-4.46, -2.11), -0.9% (-1.80, -0.02), -4.2% (-5.55, -2.76), and -2.3% (-3.80, -0.72), respectively. The Low-High group had similar associations, but the effect sizes were not as high. Conclusions: Adverse LA remodeling over 10 years of follow-up strongly correlates with prolonged elevated levels of intracardiac stress, as assessed by NT-proBNP levels.

Original languageEnglish (US)
Pages (from-to)626-635
Number of pages10
JournalAmerican journal of hypertension
Issue number6
StatePublished - Jun 22 2021

Bibliographical note

Funding Information:
This research was supported by contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences (NCATS). Additional support was provided by grant R01 HL 127659 from NHLBI.

Publisher Copyright:
© 2021 American Journal of Hypertension, Ltd 2021. All rights reserved.


  • NT-proBNP
  • blood pressure
  • cardiac magnetic resonance imaging
  • hypertension
  • left atrium
  • multimodality tissue tracking

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural


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