Association of IL-1β and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers

L. Joos, L. McIntyre, J. Ruan, J. E. Connett, N. R. Anthonisen, T. D. Weir, P. D. Paré, A. J. Sandford

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Background - There is increasing evidence that the cytokine network is central to the immunopathology of inflammatory airway diseases. The interleukin 1 (IL-1) receptor antagonist (IL-1RN) is a naturally occurring anti-inflammatory agent that binds to the IL-1 receptor but does not possess agonist activity. Each of the genes of the IL-1 locus on chromosome 2q14 is polymorphic. The IL1RN gene contains an 86 bp tandem repeat and allele 2 of this polymorphism has been associated with various inflammatory diseases. The IL-1β (IL1B) gene contains a promoter polymorphism (C-511T) that has been associated with inflammatory diseases and is in linkage disequilibrium with the IL1RN polymorphism. Methods - We investigated whether polymorphisms in the IL1B and IL1RN genes were associated with rate of decline of lung function. Genotypes were determined in 284 smokers with a rapid decline in lung function and 306 smokers with no decline in lung function. Results - None of the genotypes was associated with the rate of decline of lung function. However, the distribution of IL1B/IL1RN haplotypes was different between smokers with a rapid decline in lung function and those with no decline in lung function (p=0.0005). Conclusion - These results suggest that IL1B/IL1RN haplotypes play a role in the rate of decline in lung function in smokers.

Original languageEnglish (US)
Pages (from-to)863-866
Number of pages4
JournalThorax
Volume56
Issue number11
DOIs
StatePublished - 2001

Keywords

  • Interleukin 1
  • Lung function
  • Polymorphism (genetics)
  • Smoking

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    Joos, L., McIntyre, L., Ruan, J., Connett, J. E., Anthonisen, N. R., Weir, T. D., Paré, P. D., & Sandford, A. J. (2001). Association of IL-1β and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers. Thorax, 56(11), 863-866. https://doi.org/10.1136/thorax.56.11.863