Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic review

Abu Baker Sheikh, Prabal Kumar Chourasia, Nismat Javed, Mehul Kumar Chourasia, Sajid S. Suriya, Shubhra Upadhyay, Fatima Ijaz, Suman Pal, Narges Moghimi, Rahul Shekhar

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Objective: The systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection. Methods: After protocol registration, PubMed, Web of Science and Cumulative Index to Nursing & Allied Health Literature (CINHAL) databases were searched for relevant articles using MeSH key-words and imported into referencing/review softwares. The data, regarding demographic and clinical characteristics, diagnostic workup and management, was analyzed in International Business Machines (IBM) Statistics SPSS 21. Many statistical tests, such as t-test and the Mann–Whitney U test, were used. P < 0.05 was considered significant. Results: We identified 64 relevant articles. The mean age of the patients was 56 ± 16 years; the majority were males (64.9%). Among the neurological findings, paresthesia was the most typical symptom (48.9%). Most of the patients had been diagnosed by reverse transcriptase-polymerase chain reaction (RT-PCR) (69.2%). Two-third of the patients received immunoglobulins (IVIg) (77.7%). Although functions recovered in most patients, there were four patients with facial diplegia during follow-up (4.26%). Acute inflammatory demyelinating polyneuropathy (AIDP) was more likely to be associated with paresis of the lower extremity (p < 0.05) and higher levels of glucose on cerebrospinal fluid (CSF) analysis (p < 0.05). These patients were more likely to receive IVIg (p < 0.05) and develop respiratory insufficiency, subsequently (p < 0.05). Conclusions: GBS is being recognized as one of the many presentations of the COVID-19 infection. Although the common form is AIDP that might lead to complications, other variants are possible as well, and more studies are needed to focus on those subvariants.

Original languageEnglish (US)
Article number577577
JournalJournal of Neuroimmunology
StatePublished - Jun 15 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier B.V.


  • Acute inflammatory demyelinating polyneuropathy
  • COVID-19
  • Guillain-Barre syndrome
  • Miller-Fisher syndrome


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