Association of exotoxin-producing group a streptococci and severe disease in children

Kiran Belani, Patrick M. Schlievert, Edward L. Kaplan, Patricia Ferrieri

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Clinical features and microbiologic data on all cases of serious (hospitalized) Group A streptococcal infections in children managed at our institution between 1985 and 1988 are presented. All 6 cases were caused by toxin-producing strains. Four of 6 were toxin A-producing strains whereas none of 58 community-acquired (Group A streptococcal) pharyngeal isolates in the same period was a toxin A producer. A review of the literature on the incidence of toxin A-producing strains provides information suggesting a resurgence of such strains in the late 1980s after a relative disappearance in the preceding 30 years. The incidence of toxin B production in isolates from these patients was also significantly greater than in isolates acquired from the community in uncomplicated pharyngitis. These findings suggest a role for exotoxin in severe manifestations of Group A streptococcal disease in children.

Original languageEnglish (US)
Pages (from-to)351-354
Number of pages4
JournalPediatric Infectious Disease Journal
Issue number5
StatePublished - May 1991


  • Group a streptococcus
  • Streptococcal toxin shock
  • Streptococcal toxins
  • Toxin-producing group a streptococci

Fingerprint Dive into the research topics of 'Association of exotoxin-producing group a streptococci and severe disease in children'. Together they form a unique fingerprint.

Cite this