Background & aims: Metabolic syndrome (MetS), characterized by abdominal obesity, atherogenic dyslipidemia, elevated blood pressure, and insulin resistance is a major public health concern in the United States. Omega-3 fatty acids have been relatively well studied in relation to many individual cardiovascular risk factors; however, their effects on MetS are not well established. Methods: We conducted a cross-sectional study consisting of 4941 participants from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study to assess the relation of dietary omega-3 fatty acids with the prevalence of MetS. Omega-3 intake was assessed using a food frequency questionnaire and we used generalized estimating equations to estimate adjusted odds ratios for prevalent MetS. Results: Our study population had a mean age (SD) of 52.1 (13.9) years and 45.9% were men. The mean (SD) of dietary omega-3 fatty acids was 0.25g/day (0.27). From the lowest to the highest quintile of dietary omega-3 fatty acids, multivariable adjusted ORs (95% CI) for MetS were 1.00 (ref), 0.90 (0.72-1.13), 1.03 (0.82-1.28), 0.94 (0.74-1.18), and 0.99 (0.77-1.25), respectively. In a secondary analysis, neither fish consumption nor dietary alpha-linolenic acid was associated with MetS. Conclusions: Our findings do not support an association between dietary omega-3 fatty acids and MetS in a large US population.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Dec 2013|
Bibliographical noteFunding Information:
The NHLBI Family Heart Study was supported by the National Heart, Lung, and Blood Institute cooperative agreement grants U01 HL 67893 , U01 HL67894 , U01 HL67895 , U01 HL67896 , U01 HL67897 , U01 HL67898 , U01 HL67899 , U01 HL67900 , U01 HL67901 , U01 HL67902 , U01 HL56563 , U01 HL56564 , U01 HL56565 , U01 HL56566 , U01 HL56567 , U01 HL56568 , and U01 HL56569 . This report is presented on behalf of the investigators of the NHLBI Family Heart Study. The investigators thank the study participants and staff for their valuable contributions.
- Dietary alpha-linolenic acid (ALA)
- Metabolic syndrome
- Omega-3 fatty acids