Association of criteria pollutants with plasma hemostatic/inflammatory markers: A population-based study

Duanping Liao, Gerardo Heiss, Vernon M. Chinchilli, Yinkang Duan, Aaron R. Folsom, Hung Mo Lin, Veikko Salomaa

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To elucidate the health effects of air pollution, the short-term association of criteria pollutants (particles < 10 μm in diameter [PM 10], O3, CO, NO2, and SO2) with hemostatic and inflammatory markers were examined using a population-based sample of 10,208 middle-age males and females of the biracial cohort of Atherosclerosis Risk in Communities (ARIC) study. For each participant, we calculated the following pollutant exposures 1-3 days prior to the randomly allocated cohort examination date: PM10, CO, NO2, and SO2 as 24-h averages, and O3 as an 8-h average of the hourly measures. The hemostatic/inflammatory factors included fibrinogen, factor VIII-C, von Willebrand factor (vWF), albumin, and white blood cell count (WBC). Linear regression models were used to adjust for cardiovascular disease (CVD) risk factors, demographic and socioeconomic variables, and relevant meteorological variables. One standard deviation (SD) increment of PM 10 (12.8 μg/m3) was significantly (P < 0.05) associated with 3.93% higher of vWF among diabetics and 0.006 g/dl lower of serum albumin among persons with a history of CVD. One SD increment of CO (0.60 p.p.m.) was significantly (P < 0.01) associated with 0.018 g/dl lower of serum albumin. Significant curvilinear associations, indicative of threshold effects, for PM10 with factor VIII-C, O3 with fibrinogen and vWF, and SO2 with factor VIII-C, WBC, and serum albumin were found. This population-based study suggest that the hemostasis/inmflammation markers analyzed, which are linked to higher risk of CHD, are associated adversely with environmentally relevant ambient pollutants, with the strongest associations in the upper range of the pollutant distributions, and in persons with a positive history of diabetes and CHD.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalJournal of Exposure Analysis and Environmental Epidemiology
Issue number4
StatePublished - Jul 2005

Bibliographical note

Funding Information:
Thi s work was supported by US Nati onal Insti tute of Health, NIEHS Grant 1-R01-ES10189-01 and EPA Grant R82-7994-010. We thank the staff and participants in the ARIC study for thei r i mportant contri buti ons. We also thank the ARIC study for allowi ng us to use the ARIC data.


  • Air pollution
  • Cardiovascular disease
  • Criteria pollutants
  • Hemostasis
  • Inflammation
  • Population-based study


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