Association of cataract surgery with mortality in older women: Findings from the women's health initiative

Victoria L. Tseng, Rowan T. Chlebowski, Fei Yu, Jane A. Cauley, Wenjun Li, Fridtjof Thomas, Beth A. Virnig, Anne L. Coleman

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Abstract

IMPORTANCE Previous studies have suggested an association between cataract surgery and decreased risk for all-cause mortality potentially through a mechanism of improved health status and functional independence, but the association between cataract surgery and cause-specific mortality has not been previously studied and is not well understood. OBJECTIVE To examine the association between cataract surgery and total and cause-specific mortality in older women with cataract. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study included nationwide data collected from theWomen's Health Initiative (WHI) clinical trial and observational study linked with the Medicare claims database. Participants in the present study were 65 years or older with a diagnosis of cataract in the linked Medicare claims database. The WHI data were collected from January 1, 1993, through December 31, 2015. Data were analyzed for the present study from July 1, 2014, through September 1, 2017. EXPOSURES Cataract surgery as determined by Medicare claims codes. MAIN OUTCOMES AND MEASURES The outcomes of interest included all-cause mortality and mortality attributed to vascular, cancer, accidental, neurologic, pulmonary, and infectious causes. Mortality rates were compared by cataract surgery status using the log-rank test and Cox proportional hazards regression models adjusting for demographics, systemic and ocular comorbidities, smoking, alcohol use, body mass index, and physical activity. RESULTS A total of 74 044 women with cataract in the WHI included 41 735 who underwent cataract surgery. Mean (SD) age was 70.5 (4.6) years; the most common ethnicity was white (64 430 [87.0%]), followed by black (5293 [7.1%]) and Hispanic (1723 [2.3%]). The mortality rate was 2.56 per 100 person-years in both groups. In covariate-adjusted Cox models, cataract surgery was associated with lower all-cause mortality (adjusted hazards ratio [AHR], 0.40; 95%CI, 0.39-0.42) as well as lower mortality specific to vascular (AHR, 0.42; 95%CI, 0.39-0.46), cancer (AHR, 0.31; 95%CI, 0.29-0.34), accidental (AHR, 0.44; 95%CI, 0.33-0.58), neurologic (AHR, 0.43; 95%CI, 0.36-0.53), pulmonary (AHR, 0.63; 95%CI, 0.52-0.78), and infectious (AHR, 0.44; 95%CI, 0.36-0.54) diseases. CONCLUSIONS AND RELEVANCE In older women with cataract in the WHI, cataract surgery is associated with lower risk for total and cause-specific mortality, although whether this association is explained by the intervention of cataract surgery is unclear. Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care.

LanguageEnglish (US)
Pages3-10
Number of pages8
JournalJAMA Ophthalmology
Volume136
Issue number1
DOIs
StatePublished - Jan 1 2018

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Women's Health
Cataract
Mortality
Medicare
Proportional Hazards Models
Nervous System
Blood Vessels
Databases
Lung
Hispanic Americans
Health Status
Observational Studies
Comorbidity
Neoplasms
Patient Care
Body Mass Index
Cohort Studies
Smoking

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Tseng, V. L., Chlebowski, R. T., Yu, F., Cauley, J. A., Li, W., Thomas, F., ... Coleman, A. L. (2018). Association of cataract surgery with mortality in older women: Findings from the women's health initiative. JAMA Ophthalmology, 136(1), 3-10. DOI: 10.1001/jamaophthalmol.2017.4512

Association of cataract surgery with mortality in older women : Findings from the women's health initiative. / Tseng, Victoria L.; Chlebowski, Rowan T.; Yu, Fei; Cauley, Jane A.; Li, Wenjun; Thomas, Fridtjof; Virnig, Beth A.; Coleman, Anne L.

In: JAMA Ophthalmology, Vol. 136, No. 1, 01.01.2018, p. 3-10.

Research output: Contribution to journalArticle

Tseng, VL, Chlebowski, RT, Yu, F, Cauley, JA, Li, W, Thomas, F, Virnig, BA & Coleman, AL 2018, 'Association of cataract surgery with mortality in older women: Findings from the women's health initiative' JAMA Ophthalmology, vol 136, no. 1, pp. 3-10. DOI: 10.1001/jamaophthalmol.2017.4512
Tseng VL, Chlebowski RT, Yu F, Cauley JA, Li W, Thomas F et al. Association of cataract surgery with mortality in older women: Findings from the women's health initiative. JAMA Ophthalmology. 2018 Jan 1;136(1):3-10. Available from, DOI: 10.1001/jamaophthalmol.2017.4512
Tseng, Victoria L. ; Chlebowski, Rowan T. ; Yu, Fei ; Cauley, Jane A. ; Li, Wenjun ; Thomas, Fridtjof ; Virnig, Beth A. ; Coleman, Anne L./ Association of cataract surgery with mortality in older women : Findings from the women's health initiative. In: JAMA Ophthalmology. 2018 ; Vol. 136, No. 1. pp. 3-10
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abstract = "IMPORTANCE Previous studies have suggested an association between cataract surgery and decreased risk for all-cause mortality potentially through a mechanism of improved health status and functional independence, but the association between cataract surgery and cause-specific mortality has not been previously studied and is not well understood. OBJECTIVE To examine the association between cataract surgery and total and cause-specific mortality in older women with cataract. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study included nationwide data collected from theWomen's Health Initiative (WHI) clinical trial and observational study linked with the Medicare claims database. Participants in the present study were 65 years or older with a diagnosis of cataract in the linked Medicare claims database. The WHI data were collected from January 1, 1993, through December 31, 2015. Data were analyzed for the present study from July 1, 2014, through September 1, 2017. EXPOSURES Cataract surgery as determined by Medicare claims codes. MAIN OUTCOMES AND MEASURES The outcomes of interest included all-cause mortality and mortality attributed to vascular, cancer, accidental, neurologic, pulmonary, and infectious causes. Mortality rates were compared by cataract surgery status using the log-rank test and Cox proportional hazards regression models adjusting for demographics, systemic and ocular comorbidities, smoking, alcohol use, body mass index, and physical activity. RESULTS A total of 74 044 women with cataract in the WHI included 41 735 who underwent cataract surgery. Mean (SD) age was 70.5 (4.6) years; the most common ethnicity was white (64 430 [87.0{\%}]), followed by black (5293 [7.1{\%}]) and Hispanic (1723 [2.3{\%}]). The mortality rate was 2.56 per 100 person-years in both groups. In covariate-adjusted Cox models, cataract surgery was associated with lower all-cause mortality (adjusted hazards ratio [AHR], 0.40; 95{\%}CI, 0.39-0.42) as well as lower mortality specific to vascular (AHR, 0.42; 95{\%}CI, 0.39-0.46), cancer (AHR, 0.31; 95{\%}CI, 0.29-0.34), accidental (AHR, 0.44; 95{\%}CI, 0.33-0.58), neurologic (AHR, 0.43; 95{\%}CI, 0.36-0.53), pulmonary (AHR, 0.63; 95{\%}CI, 0.52-0.78), and infectious (AHR, 0.44; 95{\%}CI, 0.36-0.54) diseases. CONCLUSIONS AND RELEVANCE In older women with cataract in the WHI, cataract surgery is associated with lower risk for total and cause-specific mortality, although whether this association is explained by the intervention of cataract surgery is unclear. Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care.",
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N2 - IMPORTANCE Previous studies have suggested an association between cataract surgery and decreased risk for all-cause mortality potentially through a mechanism of improved health status and functional independence, but the association between cataract surgery and cause-specific mortality has not been previously studied and is not well understood. OBJECTIVE To examine the association between cataract surgery and total and cause-specific mortality in older women with cataract. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study included nationwide data collected from theWomen's Health Initiative (WHI) clinical trial and observational study linked with the Medicare claims database. Participants in the present study were 65 years or older with a diagnosis of cataract in the linked Medicare claims database. The WHI data were collected from January 1, 1993, through December 31, 2015. Data were analyzed for the present study from July 1, 2014, through September 1, 2017. EXPOSURES Cataract surgery as determined by Medicare claims codes. MAIN OUTCOMES AND MEASURES The outcomes of interest included all-cause mortality and mortality attributed to vascular, cancer, accidental, neurologic, pulmonary, and infectious causes. Mortality rates were compared by cataract surgery status using the log-rank test and Cox proportional hazards regression models adjusting for demographics, systemic and ocular comorbidities, smoking, alcohol use, body mass index, and physical activity. RESULTS A total of 74 044 women with cataract in the WHI included 41 735 who underwent cataract surgery. Mean (SD) age was 70.5 (4.6) years; the most common ethnicity was white (64 430 [87.0%]), followed by black (5293 [7.1%]) and Hispanic (1723 [2.3%]). The mortality rate was 2.56 per 100 person-years in both groups. In covariate-adjusted Cox models, cataract surgery was associated with lower all-cause mortality (adjusted hazards ratio [AHR], 0.40; 95%CI, 0.39-0.42) as well as lower mortality specific to vascular (AHR, 0.42; 95%CI, 0.39-0.46), cancer (AHR, 0.31; 95%CI, 0.29-0.34), accidental (AHR, 0.44; 95%CI, 0.33-0.58), neurologic (AHR, 0.43; 95%CI, 0.36-0.53), pulmonary (AHR, 0.63; 95%CI, 0.52-0.78), and infectious (AHR, 0.44; 95%CI, 0.36-0.54) diseases. CONCLUSIONS AND RELEVANCE In older women with cataract in the WHI, cataract surgery is associated with lower risk for total and cause-specific mortality, although whether this association is explained by the intervention of cataract surgery is unclear. Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care.

AB - IMPORTANCE Previous studies have suggested an association between cataract surgery and decreased risk for all-cause mortality potentially through a mechanism of improved health status and functional independence, but the association between cataract surgery and cause-specific mortality has not been previously studied and is not well understood. OBJECTIVE To examine the association between cataract surgery and total and cause-specific mortality in older women with cataract. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study included nationwide data collected from theWomen's Health Initiative (WHI) clinical trial and observational study linked with the Medicare claims database. Participants in the present study were 65 years or older with a diagnosis of cataract in the linked Medicare claims database. The WHI data were collected from January 1, 1993, through December 31, 2015. Data were analyzed for the present study from July 1, 2014, through September 1, 2017. EXPOSURES Cataract surgery as determined by Medicare claims codes. MAIN OUTCOMES AND MEASURES The outcomes of interest included all-cause mortality and mortality attributed to vascular, cancer, accidental, neurologic, pulmonary, and infectious causes. Mortality rates were compared by cataract surgery status using the log-rank test and Cox proportional hazards regression models adjusting for demographics, systemic and ocular comorbidities, smoking, alcohol use, body mass index, and physical activity. RESULTS A total of 74 044 women with cataract in the WHI included 41 735 who underwent cataract surgery. Mean (SD) age was 70.5 (4.6) years; the most common ethnicity was white (64 430 [87.0%]), followed by black (5293 [7.1%]) and Hispanic (1723 [2.3%]). The mortality rate was 2.56 per 100 person-years in both groups. In covariate-adjusted Cox models, cataract surgery was associated with lower all-cause mortality (adjusted hazards ratio [AHR], 0.40; 95%CI, 0.39-0.42) as well as lower mortality specific to vascular (AHR, 0.42; 95%CI, 0.39-0.46), cancer (AHR, 0.31; 95%CI, 0.29-0.34), accidental (AHR, 0.44; 95%CI, 0.33-0.58), neurologic (AHR, 0.43; 95%CI, 0.36-0.53), pulmonary (AHR, 0.63; 95%CI, 0.52-0.78), and infectious (AHR, 0.44; 95%CI, 0.36-0.54) diseases. CONCLUSIONS AND RELEVANCE In older women with cataract in the WHI, cataract surgery is associated with lower risk for total and cause-specific mortality, although whether this association is explained by the intervention of cataract surgery is unclear. Further study of the interplay of cataract surgery, systemic disease, and disease-related mortality would be informative for improved patient care.

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