Association of candidate genes with phenotypic traits relevant to anorexia nervosa

Tammy L. Root, Jin P. Szatkiewicz, Charles R. Jonassaint, Laura M. Thornton, Andrea Poyastro Pinheiro, Michael Strober, Cinnamon Bloss, Wade Berrettini, Nicholas J. Schork, Walter H. Kaye, Andrew W. Bergen, Pierre Magistretti, Harry Brandt, Steve Crawford, Scott Crow, Manfred M. Fichter, David Goldman, Katherine A. Halmi, Craig Johnson, Allan S. KaplanPamela K. Keel, Kelly L. Klump, Maria La Via, James E. Mitchell, Alessandro Rotondo, Janet Treasure, D. Blake Woodside, Cynthia M. Bulik

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalEuropean Eating Disorders Review
Volume19
Issue number6
DOIs
StatePublished - Nov 2011

Keywords

  • association studies
  • covariates
  • eating disorders
  • genetic
  • personality

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