Association of C2, a derivative of the radial artery pressure waveform, with new onset of type 2 diabetes mellitus

The MESA study

Daniel Duprez, Nkete I. Forbang, Matthew A. Allison, Carmen A. Peralta, Steven Shea, David R Jacobs Jr

Research output: Contribution to journalArticle

Abstract

Background: Although microvascular dysfunction is known to result from diabetes, it might also lead to diabetes. Lower values of C2, a derivative of the radial artery pressure waveform, indicate microvascular dysfunction and predict hypertension and cardiovascular disease (CVD). We studied the association of C2 with incident diabetes in subjects free of overt CVD. Methods: Among multi-ethnic participants (n = 5214), aged 45-84 years with no diabetes, C2 was derived from the radial artery pressure waveform. Incident diabetes (N = 651) was diagnosed as new fasting glucose ≥ 126 mg/dL or antidiabetic medicine over ~ 10 years. The relative incidence density (RID) for incident diabetes per standard deviation (SD) of C2 was studied during ~ 10 years follow-up using four levels of adjustment. Results: Mean C2 at baseline was 4.58 ± 2.85 mL/mmHg × 100. The RID for incident diabetes per SD of C2 was 0.90 (95% CI 0.82-0.99, P = 0.03). After adjustment for demographics plus body size, the corresponding RID was 0.81 (95% CI 0.73-0.89, P < 0.0001); body mass index (BMI) was the dominant covariate here. After adjustment for demographics plus cardiovascular risk factors, the RID was 0.98 (95% CI 0.89, 1.07, P = 0.63). After adjustment for all the parameters in the previous models, the RID was 0.87 (95% CI 0.78, 0.96, P = 0.006). Conclusions: In a multi-ethnic sample free of overt CVD and diabetes at baseline, C2 predicted incident diabetes after adjustment for demographics, BMI and CVD risk factors. Differences in arterial blood pressure wave morphology may indicate a long-term risk trajectory for diabetes, independently of body size and the classical risk factors.

Original languageEnglish (US)
Article number62
JournalCardiovascular Diabetology
Volume18
Issue number1
DOIs
StatePublished - May 17 2019

Fingerprint

Specific Gravity
Radial Artery
Type 2 Diabetes Mellitus
Pressure
Cardiovascular Diseases
Incidence
Demography
Body Size
Body Mass Index
Social Adjustment
Hypoglycemic Agents
Fasting
Arterial Pressure
Medicine
Hypertension
Glucose

Keywords

  • Arterial pressure waveform
  • C2
  • Cardiovascular risk factors
  • Cohort study
  • Incident diabetes type 2

Cite this

Association of C2, a derivative of the radial artery pressure waveform, with new onset of type 2 diabetes mellitus : The MESA study. / Duprez, Daniel; Forbang, Nkete I.; Allison, Matthew A.; Peralta, Carmen A.; Shea, Steven; Jacobs Jr, David R.

In: Cardiovascular Diabetology, Vol. 18, No. 1, 62, 17.05.2019.

Research output: Contribution to journalArticle

@article{dc001b9faf314eea95923db4f6076df4,
title = "Association of C2, a derivative of the radial artery pressure waveform, with new onset of type 2 diabetes mellitus: The MESA study",
abstract = "Background: Although microvascular dysfunction is known to result from diabetes, it might also lead to diabetes. Lower values of C2, a derivative of the radial artery pressure waveform, indicate microvascular dysfunction and predict hypertension and cardiovascular disease (CVD). We studied the association of C2 with incident diabetes in subjects free of overt CVD. Methods: Among multi-ethnic participants (n = 5214), aged 45-84 years with no diabetes, C2 was derived from the radial artery pressure waveform. Incident diabetes (N = 651) was diagnosed as new fasting glucose ≥ 126 mg/dL or antidiabetic medicine over ~ 10 years. The relative incidence density (RID) for incident diabetes per standard deviation (SD) of C2 was studied during ~ 10 years follow-up using four levels of adjustment. Results: Mean C2 at baseline was 4.58 ± 2.85 mL/mmHg × 100. The RID for incident diabetes per SD of C2 was 0.90 (95{\%} CI 0.82-0.99, P = 0.03). After adjustment for demographics plus body size, the corresponding RID was 0.81 (95{\%} CI 0.73-0.89, P < 0.0001); body mass index (BMI) was the dominant covariate here. After adjustment for demographics plus cardiovascular risk factors, the RID was 0.98 (95{\%} CI 0.89, 1.07, P = 0.63). After adjustment for all the parameters in the previous models, the RID was 0.87 (95{\%} CI 0.78, 0.96, P = 0.006). Conclusions: In a multi-ethnic sample free of overt CVD and diabetes at baseline, C2 predicted incident diabetes after adjustment for demographics, BMI and CVD risk factors. Differences in arterial blood pressure wave morphology may indicate a long-term risk trajectory for diabetes, independently of body size and the classical risk factors.",
keywords = "Arterial pressure waveform, C2, Cardiovascular risk factors, Cohort study, Incident diabetes type 2",
author = "Daniel Duprez and Forbang, {Nkete I.} and Allison, {Matthew A.} and Peralta, {Carmen A.} and Steven Shea and {Jacobs Jr}, {David R}",
year = "2019",
month = "5",
day = "17",
doi = "10.1186/s12933-019-0868-3",
language = "English (US)",
volume = "18",
journal = "Cardiovascular Diabetology",
issn = "1475-2840",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Association of C2, a derivative of the radial artery pressure waveform, with new onset of type 2 diabetes mellitus

T2 - The MESA study

AU - Duprez, Daniel

AU - Forbang, Nkete I.

AU - Allison, Matthew A.

AU - Peralta, Carmen A.

AU - Shea, Steven

AU - Jacobs Jr, David R

PY - 2019/5/17

Y1 - 2019/5/17

N2 - Background: Although microvascular dysfunction is known to result from diabetes, it might also lead to diabetes. Lower values of C2, a derivative of the radial artery pressure waveform, indicate microvascular dysfunction and predict hypertension and cardiovascular disease (CVD). We studied the association of C2 with incident diabetes in subjects free of overt CVD. Methods: Among multi-ethnic participants (n = 5214), aged 45-84 years with no diabetes, C2 was derived from the radial artery pressure waveform. Incident diabetes (N = 651) was diagnosed as new fasting glucose ≥ 126 mg/dL or antidiabetic medicine over ~ 10 years. The relative incidence density (RID) for incident diabetes per standard deviation (SD) of C2 was studied during ~ 10 years follow-up using four levels of adjustment. Results: Mean C2 at baseline was 4.58 ± 2.85 mL/mmHg × 100. The RID for incident diabetes per SD of C2 was 0.90 (95% CI 0.82-0.99, P = 0.03). After adjustment for demographics plus body size, the corresponding RID was 0.81 (95% CI 0.73-0.89, P < 0.0001); body mass index (BMI) was the dominant covariate here. After adjustment for demographics plus cardiovascular risk factors, the RID was 0.98 (95% CI 0.89, 1.07, P = 0.63). After adjustment for all the parameters in the previous models, the RID was 0.87 (95% CI 0.78, 0.96, P = 0.006). Conclusions: In a multi-ethnic sample free of overt CVD and diabetes at baseline, C2 predicted incident diabetes after adjustment for demographics, BMI and CVD risk factors. Differences in arterial blood pressure wave morphology may indicate a long-term risk trajectory for diabetes, independently of body size and the classical risk factors.

AB - Background: Although microvascular dysfunction is known to result from diabetes, it might also lead to diabetes. Lower values of C2, a derivative of the radial artery pressure waveform, indicate microvascular dysfunction and predict hypertension and cardiovascular disease (CVD). We studied the association of C2 with incident diabetes in subjects free of overt CVD. Methods: Among multi-ethnic participants (n = 5214), aged 45-84 years with no diabetes, C2 was derived from the radial artery pressure waveform. Incident diabetes (N = 651) was diagnosed as new fasting glucose ≥ 126 mg/dL or antidiabetic medicine over ~ 10 years. The relative incidence density (RID) for incident diabetes per standard deviation (SD) of C2 was studied during ~ 10 years follow-up using four levels of adjustment. Results: Mean C2 at baseline was 4.58 ± 2.85 mL/mmHg × 100. The RID for incident diabetes per SD of C2 was 0.90 (95% CI 0.82-0.99, P = 0.03). After adjustment for demographics plus body size, the corresponding RID was 0.81 (95% CI 0.73-0.89, P < 0.0001); body mass index (BMI) was the dominant covariate here. After adjustment for demographics plus cardiovascular risk factors, the RID was 0.98 (95% CI 0.89, 1.07, P = 0.63). After adjustment for all the parameters in the previous models, the RID was 0.87 (95% CI 0.78, 0.96, P = 0.006). Conclusions: In a multi-ethnic sample free of overt CVD and diabetes at baseline, C2 predicted incident diabetes after adjustment for demographics, BMI and CVD risk factors. Differences in arterial blood pressure wave morphology may indicate a long-term risk trajectory for diabetes, independently of body size and the classical risk factors.

KW - Arterial pressure waveform

KW - C2

KW - Cardiovascular risk factors

KW - Cohort study

KW - Incident diabetes type 2

UR - http://www.scopus.com/inward/record.url?scp=85065926435&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065926435&partnerID=8YFLogxK

U2 - 10.1186/s12933-019-0868-3

DO - 10.1186/s12933-019-0868-3

M3 - Article

VL - 18

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

SN - 1475-2840

IS - 1

M1 - 62

ER -