Association of Atrial Fibrillation With White Matter Disease: The ARIC Study

Iris Yuefan Shao, Melinda C. Power, Thomas Mosley, Clifford Jack, Rebecca F. Gottesman, Lin Y. Chen, Faye L. Norby, Elsayed Z. Soliman, Alvaro Alonso

Research output: Contribution to journalArticle

Abstract

Background and Purpose - Evidence suggests that atrial fibrillation (AF) is associated with increased risk of cognitive decline and dementia, even in the absence of stroke. White matter disease (WMD) is a potential mechanism linking AF to cognitive impairment. In this study, we explored the association between prevalent AF and WMD. Methods - We performed a cross-sectional analysis of participants attending the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study) in 2011 to 2013 who underwent brain magnetic resonance imaging. AF was ascertained from study visit electrocardiograms or prior hospitalization codes. Extent of WMD was defined by measures of white matter (WM) microstructural integrity and WM hyperintensity volume. Multivariable linear regression models were used to assess the association between AF and WMD. Results - Among 1899 participants (mean age, 76 years; 28% black; 60% women), 133 (7%) had prevalent AF. After multivariable adjustment, differences between participants with and without AF were -0.001 (95% CI, -0.006 to 0.004) for global WM fractional anisotropy, 0.031×10-4 mm2/s (95% CI, -0.075 to 0.137) for global WM mean diffusivity, and 0.08 mm3 (95% CI, -0.14 to 0.30) for WM hyperintensity volume. Conclusions - The results suggest that there is no association between prevalent AF and WMD.

Original languageEnglish (US)
Pages (from-to)989-991
Number of pages3
JournalStroke
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2019

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Leukoencephalopathies
Atrial Fibrillation
Linear Models
Social Adjustment
Anisotropy
Dementia
Atherosclerosis
Electrocardiography
Hospitalization
Cross-Sectional Studies
Stroke
Magnetic Resonance Imaging
White Matter
Brain

Keywords

  • atrial fibrillation
  • cognitive dysfunction
  • dementia
  • leukoencephalopathies
  • white matter

Cite this

Shao, I. Y., Power, M. C., Mosley, T., Jack, C., Gottesman, R. F., Chen, L. Y., ... Alonso, A. (2019). Association of Atrial Fibrillation With White Matter Disease: The ARIC Study. Stroke, 50(4), 989-991. https://doi.org/10.1161/STROKEAHA.118.023386

Association of Atrial Fibrillation With White Matter Disease : The ARIC Study. / Shao, Iris Yuefan; Power, Melinda C.; Mosley, Thomas; Jack, Clifford; Gottesman, Rebecca F.; Chen, Lin Y.; Norby, Faye L.; Soliman, Elsayed Z.; Alonso, Alvaro.

In: Stroke, Vol. 50, No. 4, 01.04.2019, p. 989-991.

Research output: Contribution to journalArticle

Shao, IY, Power, MC, Mosley, T, Jack, C, Gottesman, RF, Chen, LY, Norby, FL, Soliman, EZ & Alonso, A 2019, 'Association of Atrial Fibrillation With White Matter Disease: The ARIC Study', Stroke, vol. 50, no. 4, pp. 989-991. https://doi.org/10.1161/STROKEAHA.118.023386
Shao, Iris Yuefan ; Power, Melinda C. ; Mosley, Thomas ; Jack, Clifford ; Gottesman, Rebecca F. ; Chen, Lin Y. ; Norby, Faye L. ; Soliman, Elsayed Z. ; Alonso, Alvaro. / Association of Atrial Fibrillation With White Matter Disease : The ARIC Study. In: Stroke. 2019 ; Vol. 50, No. 4. pp. 989-991.
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