Association of Atrial Fibrillation With White Matter Disease: The ARIC Study

Iris Yuefan Shao, Melinda C. Power, Thomas Mosley, Clifford Jack, Rebecca F. Gottesman, Lin Y. Chen, Faye L. Norby, Elsayed Z. Soliman, Alvaro Alonso

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background and Purpose - Evidence suggests that atrial fibrillation (AF) is associated with increased risk of cognitive decline and dementia, even in the absence of stroke. White matter disease (WMD) is a potential mechanism linking AF to cognitive impairment. In this study, we explored the association between prevalent AF and WMD. Methods - We performed a cross-sectional analysis of participants attending the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study) in 2011 to 2013 who underwent brain magnetic resonance imaging. AF was ascertained from study visit electrocardiograms or prior hospitalization codes. Extent of WMD was defined by measures of white matter (WM) microstructural integrity and WM hyperintensity volume. Multivariable linear regression models were used to assess the association between AF and WMD. Results - Among 1899 participants (mean age, 76 years; 28% black; 60% women), 133 (7%) had prevalent AF. After multivariable adjustment, differences between participants with and without AF were -0.001 (95% CI, -0.006 to 0.004) for global WM fractional anisotropy, 0.031×10-4 mm2/s (95% CI, -0.075 to 0.137) for global WM mean diffusivity, and 0.08 mm3 (95% CI, -0.14 to 0.30) for WM hyperintensity volume. Conclusions - The results suggest that there is no association between prevalent AF and WMD.

Original languageEnglish (US)
Pages (from-to)989-991
Number of pages3
JournalStroke
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2019

Bibliographical note

Funding Information:
The ARIC study (Atherosclerosis Risk in Communities) has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute/National Institutes of Health under

Funding Information:
contract numbers HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201 700004I. Neurocognitive data are collected by U01 HL096812, HL096814, HL096899, HL096902, and HL096917 with previous brain MRI examinations funded by R01-HL70825. This work was additionally supported by American Heart Association grant 16EIA26410001 (Alonso).

Funding Information:
The ARIC study (Atherosclerosis Risk in Communities) has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute/National Institutes of Health under contract numbers HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, and HHSN268201 700004I. Neurocognitive data are collected by U01 HL096812, HL096814, HL096899, HL096902, and HL096917 with previous brain MRI examinations funded by R01-HL70825. This work was additionally supported by American Heart Association grant 16EIA26410001 (Alonso).

Publisher Copyright:
© 2019 American Heart Association, Inc.

Keywords

  • atrial fibrillation
  • cognitive dysfunction
  • dementia
  • leukoencephalopathies
  • white matter

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