Association of atrial fibrillation with incidence of extracranial systemic embolic events: The aric study

Mengyuan Shi, Lin Y. Chen, Wobo Bekwelem, Faye L. Norby, Elsayed Z. Soliman, Aniqa B. Alam, Alvaro Alonso

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

BACKGROUND: Atrial fibrillation (AF) increases the risk of stroke and extracranial systemic embolic events (SEEs), but little is known about the magnitude of the association of AF with SEE. METHODS AND RESULTS: This analysis included 14 941 participants of the ARIC (Atherosclerosis Risk in Communities) study (mean age, 54.2±5.8, 55% women, 74% White) without AF at baseline (1987–1989) followed through 2017. AF was identified from study ECGs, hospital discharges, and death certificates, while SEEs were ascertained from hospital discharges. CHA2 DS2-VASc was calculated at the time of AF diagnosis. Cox regression was used to estimate associations of incident AF with SEE risk in the entire cohort, and between CHA2 DS2-VASc score and SEE risk in those with AF. Among eligible participants, 3114 participants developed AF and 270 had an SEE (59 events in AF). Incident AF was associated with increased risk of SEE (hazard ratio [HR], 3.58; 95% CI, 2.57–5.00), after adjusting for covariates. The association of incident AF with SEE was stronger in women (HR, 5.26; 95% CI, 3.28–8.44) than in men (HR, 2.68; 95% CI, 1.66–4.32). In those with AF, higher CHA2 DS2-VASc score was associated with increased SEE risk (HR per 1-point increase, 1.24; 95% CI, 1.05–1.47). CONCLUSIONS: AF is associated with more than a tripling of the risk of SEE, with a stronger association in women than in men. CHA2 DS2-VASc is associated with SEE risk in AF patients, highlighting the value of the score to predict adverse outcomes and guide treatment decisions in people with AF.

Original languageEnglish (US)
Article numbere016724
JournalJournal of the American Heart Association
Volume9
Issue number18
DOIs
StatePublished - Nov 3 2020

Bibliographical note

Funding Information:
The ARIC study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I). This work was additionally supported by American Heart Association grant 16EIA26410001 (Alonso) and National Heart, Lung, and Blood Institute K24HL148521.

Funding Information:
The ARIC study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I). This work was additionally supported by American Heart Association grant 16EIA26410001 (Alonso) and National Heart, Lung, and Blood InstituteK24HL148521.

Publisher Copyright:
© 2020 The Authors.

Keywords

  • Atrial fibrillation
  • CHA DS-VASc score
  • Extracranial systemic embolism

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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