Objective - The relationship between air pollution and cardiovascular disease may be explained by changes in high-density lipoprotein (HDL). Approach and Results - We examined the cross-sectional relationship between air pollution and both HDL cholesterol and HDL particle number in the MESA Air study (Multi-Ethnic Study of Atherosclerosis Air Pollution). Study participants were 6654 white, black, Hispanic, and Chinese men and women aged 45 to 84 years. We estimated individual residential ambient fine particulate pollution exposure (PM2.5) and black carbon concentrations using a fine-scale likelihood-based spatiotemporal model and cohort-specific monitoring. Exposure periods were averaged to 12 months, 3 months, and 2 weeks prior to examination. HDL cholesterol and HDL particle number were measured in the year 2000 using the cholesterol oxidase method and nuclear magnetic resonance spectroscopy, respectively. We used multivariable linear regression to examine the relationship between air pollution exposure and HDL measures. A 0.7×10-6 m-1 higher exposure to black carbon (a marker of traffic-related pollution) averaged over a 1-year period was significantly associated with a lower HDL cholesterol (-1.68 mg/dL; 95% confidence interval, -2.86 to -0.50) and approached significance with HDL particle number (-0.55 mg/dL; 95% confidence interval, -1.13 to 0.03). In the 3-month averaging time period, a 5 μg/m3 higher PM2.5 was associated with lower HDL particle number (-0.64 μmol/L; 95% confidence interval, -1.01 to -0.26), but not HDL cholesterol (-0.05 mg/dL; 95% confidence interval, -0.82 to 0.71). Conclusions - These data are consistent with the hypothesis that exposure to air pollution is adversely associated with measures of HDL.
|Original language||English (US)|
|Number of pages||7|
|Journal||Arteriosclerosis, thrombosis, and vascular biology|
|State||Published - May 1 2017|
Bibliographical noteFunding Information:
This research was supported by National Heart, Lung, and Blood Institute contracts N01-HC-95159 through N01-HC-95169, R01-HL-077612, and HL-075476, National Center for Research Resources grants UL1-TR-000040 and UL1-TR-00107, National Institute for Environmental Health Sciences grants F31ES025096, K24ES013195, P50ES015915, and P30ES07033, and an unrestricted grant from LipoScience, Inc. This publication was developed under STAR research assistance agreements RD831697 (MESA Air [Multi-Ethnic Study of Atherosclerosis Air Pollution]) and R834796 by the US Environmental Protection Agency (EPA). It has not been formally reviewed by the EPA.
- air pollution
- cohort study
- high-density lipoprotein
- high-density lipoprotein cholesterol