Abstract
Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leu-koencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.
| Original language | English (US) |
|---|---|
| Article number | 19 |
| Journal | Free Neuropathology |
| Volume | 2 |
| DOIs | |
| State | Published - 2021 |
Bibliographical note
Funding Information:M.-P.C., S.B., E.L., and F.D. are supported by the Fonds de Recherche du Québec—Santé.
Publisher Copyright:
© 2021 The author(s).
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Acute disseminated encephalomyelitis (ADEM)
- Acute hemorrhagic leukoencephalitis (AHLE)
- Acute necrotizing encephalopathy of childhood (ANEC)
- COVID-19
- Demyelinating
- SARS-CoV-2
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