Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient

Liam Chen

doi:10.17879/freeneuropathology-2021-3388

Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient

Research output: Contribution to journal › Article › peer-review

Abstract

Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leu-koencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.

Original language	English (US)
Article number	19
Journal	Free Neuropathology
Volume	2
DOIs	https://doi.org/10.17879/freeneuropathology-2021-3388
State	Published - 2021

Bibliographical note

Funding Information:
M.-P.C., S.B., E.L., and F.D. are supported by the Fonds de Recherche du Québec—Santé.

Publisher Copyright:
© 2021 The author(s).

Keywords

Acute disseminated encephalomyelitis (ADEM)
Acute hemorrhagic leukoencephalitis (AHLE)
Acute necrotizing encephalopathy of childhood (ANEC)
COVID-19
Demyelinating
SARS-CoV-2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.17879/freeneuropathology-2021-3388

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title = "Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient",

abstract = "Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leu-koencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.",

keywords = "Acute disseminated encephalomyelitis (ADEM), Acute hemorrhagic leukoencephalitis (AHLE), Acute necrotizing encephalopathy of childhood (ANEC), COVID-19, Demyelinating, SARS-CoV-2",

author = "Liam Chen",

note = "Funding Information: M.-P.C., S.B., E.L., and F.D. are supported by the Fonds de Recherche du Qu{\'e}bec—Sant{\'e}. Publisher Copyright: {\textcopyright} 2021 The author(s).",

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AB - Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leu-koencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.

KW - Acute disseminated encephalomyelitis (ADEM)

KW - Acute hemorrhagic leukoencephalitis (AHLE)

KW - Acute necrotizing encephalopathy of childhood (ANEC)

KW - COVID-19

KW - Demyelinating

KW - SARS-CoV-2

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Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient

Abstract

Bibliographical note

Keywords

UN SDGs

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