Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leu-koencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.
|Original language||English (US)|
|State||Published - 2021|
Bibliographical noteFunding Information:
M.-P.C., S.B., E.L., and F.D. are supported by the Fonds de Recherche du Québec—Santé.
© 2021 The author(s).
- Acute disseminated encephalomyelitis (ADEM)
- Acute hemorrhagic leukoencephalitis (AHLE)
- Acute necrotizing encephalopathy of childhood (ANEC)