Association of acute disseminated encephalomyelitis (ADEM) and COVID-19 in a pediatric patient

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Cases of acute disseminated encephalomyelitis (ADEM) and its hyperacute form, acute hemorrhagic leu-koencephalitis (AHLE), have been reported in coronavirus disease 2019 (COVID-19) patients as rare, but most severe neurological complications. However, histopathologic evaluations of ADEM/AHLE pathology in COVID patients are extremely limited, so far having only been reported in a few adult autopsy cases. Here we compare the findings with an ADEM-like pathology in a pediatric patient taken through a biopsy procedure. Understanding the neuropathology may shed informative light on the autoimmune process affecting COVID-19 patients and provide critical information to guide the clinical management.

Original languageEnglish (US)
Article number19
JournalFree Neuropathology
StatePublished - 2021

Bibliographical note

Funding Information:
M.-P.C., S.B., E.L., and F.D. are supported by the Fonds de Recherche du Québec—Santé.

Publisher Copyright:
© 2021 The author(s).


  • Acute disseminated encephalomyelitis (ADEM)
  • Acute hemorrhagic leukoencephalitis (AHLE)
  • Acute necrotizing encephalopathy of childhood (ANEC)
  • COVID-19
  • Demyelinating
  • SARS-CoV-2


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