Association of Acculturation and Hispanic/Latino Background with Endogenous Sex and Thyroid-Related Hormones Among Middle-Aged and Older Hispanic/Latino Adults: the HCHS/SOL Study

Chibuzor Abasilim, Victoria Persky, Robert M. Sargis, Maria Argos, Martha L. Daviglus, Sally Freels, Konstantina Tsintsifas, Tessa Day, Jianwen Cai, Carmen R. Isasi, Brandilyn A. Peters, Gregory A. Talavera, Bharat Thyagarajan, Mary E. Turyk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Hormones are linked to cardiometabolic diseases and may be impacted by acculturation though multiple mechanisms. We evaluated associations of Hispanic/Latino background and acculturation with levels of sex- and thyroid-related hormones and the potential mediating effect of adiposity, lifestyle factors, and sleep apnea syndrome on these associations. Methods: We studied 1789 adults, aged 45–74, from a sub-cohort of the Hispanic Community Health Survey/Study of Latinos. Peri/pre-menopausal women and individuals on medications related to hormones were excluded. Our study assessed eleven sex- and thyroid-related hormones, Hispanic/Latino background, and five acculturation measures. Associations were assessed using multivariable linear and logistic regression adjusted for survey design and confounding variables. We explored potential mediation using a path analysis. Results: In postmenopausal women, acculturation score-MESA was associated with decreased thyroid-stimulating hormone (β = − 0.13;95%CI = − 0.22, − 0.03) while age at immigration greater than the median (vs US-born) was associated with decreased (β = − 14.6; 95%CI = − 28.2, − 0.99) triiodothyronine (T3). In men, language acculturation and acculturation score-MESA were associated with increased estradiol and sex hormone-binding globulin (SHBG) while age at immigration greater and lesser than the median (vs US-born) was associated with decreased SHBG. Hispanic/Latino background (Mexicans as reference) were selectively associated with sex- and thyroid-related hormone levels in both sexes. Current smoking and sleep apnea syndrome partially mediated the association of Cuban and Puerto Rican heritage (vs Mexican) with T3 levels in men and postmenopausal women, respectively. Conclusion: Selected acculturation measures were associated with thyroid-related hormones in postmenopausal women and sex-related hormones in men. Understanding the mechanisms involved in the relationship of acculturation and Hispanic/Latino background with hormones warrants additional investigation.

Original languageEnglish (US)
JournalJournal of Racial and Ethnic Health Disparities
DOIs
StateAccepted/In press - 2023

Bibliographical note

Publisher Copyright:
© 2023, W. Montague Cobb-NMA Health Institute.

Keywords

  • Acculturation
  • Hispanic/Latino
  • Mediation
  • Sex hormones
  • Structural equation model
  • Thyroid hormones

PubMed: MeSH publication types

  • Journal Article

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