Association of abdominal muscle composition with prediabetes and diabetes

The CARDIA study

Andrea Granados, Achamyeleh Gebremariam, Samuel S. Gidding, James G. Terry, John Jeffrey Carr, Lyn M Steffen, David R Jacobs Jr, Joyce M. Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: To evaluate the relationship of abdominal muscle lean tissue and adipose tissue volumes with prediabetes and diabetes. Research Design and Methods: We measured abdominal muscle composition in 3170 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who underwent computed tomography (CT) at Year 25 of follow-up (ages, 43-55 years). Multinomial regression analysis was used to evaluate the associations of CT-measured intermuscular adipose tissue (IMAT), lean muscle tissue (lean) and visceral adipose tissue (VAT) volumes with diabetes at any point during the CARDIA study, newly detected prediabetes, prior history of prediabetes, and normal glucose tolerance. Models were adjusted for potential confounding factors: age, sex, race, height, smoking status, hypertension, hyperlipidaemia, cardiorespiratory fitness and study centre. Results: Higher IMAT, lean and VAT volumes were all separately associated with a higher prevalence of prediabetes and diabetes. Inclusion of VAT volume in models with both IMAT volume and lean volume attenuated the association of IMAT with both prediabetes and diabetes, but higher lean volume retained its association with prediabetes and diabetes. Individuals in the highest IMAT quartile, coupled with VAT in its lower three quartiles, had a higher prevalence of diabetes, but not of prediabetes, than those with both IMAT and VAT in their respective lower three quartiles. Adjusting for cardiorespiratory fitness did not substantially change the findings. Conclusion: Higher IMAT volume was associated with a higher prevalence of diabetes even after adjustment for VAT volume. However, further study is warranted to understand the complicated relationship between abdominal muscle and adipose tissues.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalDiabetes, Obesity and Metabolism
Volume21
Issue number2
DOIs
StatePublished - Feb 1 2019

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Prediabetic State
Abdominal Muscles
Intra-Abdominal Fat
Adipose Tissue
Young Adult
Coronary Vessels
Muscles
Fitness Centers
Tomography
Sex Factors
Abdominal Fat
Age Factors
Hyperlipidemias
Research Design
Smoking
Regression Analysis
Hypertension
Glucose

Keywords

  • body composition
  • glycaemic control
  • type 2 diabetes

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

Cite this

Granados, A., Gebremariam, A., Gidding, S. S., Terry, J. G., Carr, J. J., Steffen, L. M., ... Lee, J. M. (2019). Association of abdominal muscle composition with prediabetes and diabetes: The CARDIA study. Diabetes, Obesity and Metabolism, 21(2), 267-275. https://doi.org/10.1111/dom.13513

Association of abdominal muscle composition with prediabetes and diabetes : The CARDIA study. / Granados, Andrea; Gebremariam, Achamyeleh; Gidding, Samuel S.; Terry, James G.; Carr, John Jeffrey; Steffen, Lyn M; Jacobs Jr, David R; Lee, Joyce M.

In: Diabetes, Obesity and Metabolism, Vol. 21, No. 2, 01.02.2019, p. 267-275.

Research output: Contribution to journalArticle

Granados, Andrea ; Gebremariam, Achamyeleh ; Gidding, Samuel S. ; Terry, James G. ; Carr, John Jeffrey ; Steffen, Lyn M ; Jacobs Jr, David R ; Lee, Joyce M. / Association of abdominal muscle composition with prediabetes and diabetes : The CARDIA study. In: Diabetes, Obesity and Metabolism. 2019 ; Vol. 21, No. 2. pp. 267-275.
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