Association of a common D3 dopamine receptor gene variant is associated with sensation seeking in skiers and snowboarders

Cynthia J. Thomson; Scott R. Carlson; Jim L. Rupert

doi:10.1016/j.jrp.2012.11.004

Association of a common D3 dopamine receptor gene variant is associated with sensation seeking in skiers and snowboarders

Cynthia J. Thomson, Scott R. Carlson, Jim L. Rupert

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8 Scopus citations

Abstract

The 'sensation seeking' trait has been associated with risky behaviors including high-risk sport participation. Genes involved in dopaminergic neurotransmission have been investigated in studies of approach traits; however, not in sporting contexts. We used joint-analysis to investigate the relationship between monoamine-neurotransmitter gene variants and impulsive and sport-specific sensation seeking in skiers (n= 599). An initial screen identified a few variants that were associated with sensation seeking, one of which, a G/A transition (rs167771) in the D3-receptor gene (DRD3), remained significant in the combined sample and after correction for multiple testing (p= .004, ηp2=.02). DRD3 variants have been associated with approach traits; however, our results are the first to suggest a role for rs167771 in sensation seeking.

Original language	English (US)
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of Research in Personality
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/j.jrp.2012.11.004
State	Published - Apr 2013

Bibliographical note

Funding Information:
We thank A.K. Rajala (Dept. Science, UBC) for her assistance in sample preparation. This project was supported in part by a UBC Faculty of Education Student Research Support grant to CJT. CJT is the recipient of a Canadian Institute for Health Research Canada Graduate Scholarship.

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

Behavior genetics
DRD3
Dopamine
High-risk sport
Sensation seeking

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10.1016/j.jrp.2012.11.004

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abstract = "The 'sensation seeking' trait has been associated with risky behaviors including high-risk sport participation. Genes involved in dopaminergic neurotransmission have been investigated in studies of approach traits; however, not in sporting contexts. We used joint-analysis to investigate the relationship between monoamine-neurotransmitter gene variants and impulsive and sport-specific sensation seeking in skiers (n= 599). An initial screen identified a few variants that were associated with sensation seeking, one of which, a G/A transition (rs167771) in the D3-receptor gene (DRD3), remained significant in the combined sample and after correction for multiple testing (p= .004, ηp2=.02). DRD3 variants have been associated with approach traits; however, our results are the first to suggest a role for rs167771 in sensation seeking.",

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note = "Funding Information: We thank A.K. Rajala (Dept. Science, UBC) for her assistance in sample preparation. This project was supported in part by a UBC Faculty of Education Student Research Support grant to CJT. CJT is the recipient of a Canadian Institute for Health Research Canada Graduate Scholarship. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

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AU - Rupert, Jim L.

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PY - 2013/4

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N2 - The 'sensation seeking' trait has been associated with risky behaviors including high-risk sport participation. Genes involved in dopaminergic neurotransmission have been investigated in studies of approach traits; however, not in sporting contexts. We used joint-analysis to investigate the relationship between monoamine-neurotransmitter gene variants and impulsive and sport-specific sensation seeking in skiers (n= 599). An initial screen identified a few variants that were associated with sensation seeking, one of which, a G/A transition (rs167771) in the D3-receptor gene (DRD3), remained significant in the combined sample and after correction for multiple testing (p= .004, ηp2=.02). DRD3 variants have been associated with approach traits; however, our results are the first to suggest a role for rs167771 in sensation seeking.

AB - The 'sensation seeking' trait has been associated with risky behaviors including high-risk sport participation. Genes involved in dopaminergic neurotransmission have been investigated in studies of approach traits; however, not in sporting contexts. We used joint-analysis to investigate the relationship between monoamine-neurotransmitter gene variants and impulsive and sport-specific sensation seeking in skiers (n= 599). An initial screen identified a few variants that were associated with sensation seeking, one of which, a G/A transition (rs167771) in the D3-receptor gene (DRD3), remained significant in the combined sample and after correction for multiple testing (p= .004, ηp2=.02). DRD3 variants have been associated with approach traits; however, our results are the first to suggest a role for rs167771 in sensation seeking.

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Association of a common D3 dopamine receptor gene variant is associated with sensation seeking in skiers and snowboarders

Abstract

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Keywords

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