Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis

Wen Ye, Daniel H. Leung, Jean P. Molleston, Simon C. Ling, Karen F. Murray, Jennifer L. Nicholas, Suiyuan Huang, Boaz W. Karmazyn, Roger K. Harned, Prakash Masand, Adina L. Alazraki, Oscar M. Navarro, Randolph K. Otto, Joseph J. Palermo, Alexander J. Towbin, Estella M. Alonso, Wikrom W. Karnsakul, Sarah Jane Schwarzenberg, Glenn F. Seidel, Marilyn SiegelJohn C. Magee, Michael R. Narkewicz, A. Jay Freeman

Research output: Contribution to journalArticlepeer-review

Abstract

Methods to identify children with cystic fibrosis (CF) at risk for development of advanced liver disease are lacking. We aim to determine the association between liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) with research ultrasound (US) patterns and conventional hepatic markers as a potential means to follow liver disease progression in children with CF. ELASTIC (Longitudinal Assessment of Transient Elastography in CF) is a nested cohort of 141 patients, ages 7-21, enrolled in the Prediction by US of Risk of Hepatic Cirrhosis in CF (PUSH) Study. We studied the association between LSM with research-grade US patterns (normal [NL], heterogeneous [HTG], homogeneous [HMG], or nodular [NOD]) and conventional hepatic markers. In a subgroup (n = 79), the association between controlled attenuation parameter (CAP) and US pattern was explored. Among 133 subjects undergoing VCTE, NOD participants (n = 26) had a significantly higher median (interquartile range) LSM of 9.1 kPa (6.3, 15.8) versus NL (n = 72, 5.1 kPa [4.2, 7.0]; P < 0.0001), HMG (n = 17, 5.9 kPa [5.2, 7.8]; P = 0.0013), and HTG (n = 18, 6.1 kPa [4.7, 7.0]; P = 0.0008) participants. HMG participants (n = 14) had a significantly higher mean CAP (SD) (270.5 dB/m [61.1]) compared with NL (n = 40, 218.8 dB/m [46.5]; P = 0.0027), HTG (n = 10, 218.1 dB/m [60.7]; P = 0.044), and NOD (n = 15, 222.7 dB/m [56.4]; P = 0.041) participants. LSM had a negative correlation with platelet count (r s = - 0.28, P = 0.0071) and positive correlation with aspartate aminotransferase-to-platelet ratio index (r s = 0.38, P = 0.0002), Fibrosis-4 index (r s = 0.36, P = 0.0007), gamma-glutamyltransferase (GGT; r s = 0.35, P = 0.0017), GGT-to-platelet ratio (r s = 0.35, P = 0.003), and US spleen size z-score (r s = 0.27, P = 0.0073). Conclusion: VCTE is associated with US patterns and conventional markers in patients with liver disease with CF.

Original languageEnglish (US)
Pages (from-to)1362-1372
Number of pages11
JournalHepatology Communications
Volume5
Issue number8
DOIs
StatePublished - Aug 2021

Bibliographical note

Funding Information:
Potential conflict of interest: Dr. Molleston received grants from Mirum, Gilead, AbbVie, and Albireo. Dr. Ling received grants from AbbVie and Gilead. Dr. Murray consults for Gilead and Albireo. Dr. Narkewicz consults for Vertez. He received grants from Gilead and AbbVie. Dr. Schwarzenberg consults for UpToDate. She received grants from Gilead. Dr. Towbin consults for Applied Radiology. He received grants from Guerbet. He has intellectual property rights in Elsevier. Dr. Karnsakul consults for Albireo and Gilead.

Funding Information:
Supported by the Cystic Fibrosis Foundation (NARKEW17AB0 to M.N.) and the National Institutes of Health NIDDK U01 DK062453 to M.N. and NIDDK U24 DK062456 to J.M.).

Publisher Copyright:
© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of the American Association for the Study of Liver Diseases.

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