Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: The MESA study

Younghoon Kwon; Jeffrey R. Misialek; Daniel Duprez; Alvaro Alonso; David R. Jacobs; Susan R. Heckbert; Susan Redline; Elsayed Z. Soliman

doi:10.1093/europace/euw328

Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: The MESA study

Younghoon Kwon, Jeffrey R. Misialek, Daniel Duprez, Alvaro Alonso, David R. Jacobs, Susan R. Heckbert, Susan Redline, Elsayed Z. Soliman

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Sleep disordered breathing (SDB) is a common condition increasingly recognized as a risk factor for atrial fibrillation (AF).1,2 Long P wave duration, an electrocardiographic (ECG) marker of atrial remodelling, was shown in patients with SDB highlighting the potential role of atrial remodelling in linking SDB to AF.3 This study was limited by small sample sizes of selected patients from sleep clinics. Emerging literature indicates that an ECG marker for P wave terminal force (PTF) identifies atrial abnormalities strongly linked to AF and stroke.4 However, the association between PTF and SDB has not been explored previously. Therefore, we sought to examine the association of ECG markers of left atrial (LA) abnormalities in relation to SDB in a large, representative population in this study, with a specific interest in PTF in V1(PTFV1) as a sensitive marker of LA abnormalities.

Original language	English (US)
Pages (from-to)	1759-1766
Number of pages	8
Journal	Europace
Volume	19
Issue number	11
DOIs	https://doi.org/10.1093/europace/euw328
State	Published - Nov 1 2017

Bibliographical note

Funding Information:
This research was supported by contracts N01 HC 95159, N01 HC 95160, N01 HC 95161, N01 HC 95162, N01 HC 95163, N01 HC 95164, N01 HC 95165, N01 HC 95166, N01 HC 95167, N01 HC 95168 and N01 HC 95169 from the NHBLI, by grants UL1 TR 000040, UL1 RR 025005 from NCRR, R01HL098433 (MESA Sleep) and T32 HL069764.

Publisher Copyright:
© The Author 2016. For permissions.

Keywords

Atrial fibrillation
Epidemiology
P wave index
P wave terminal force
Sleep apnoe
Sleep disordered breathing

Publisher link

10.1093/europace/euw328

Find It

Find It at U of M Libraries

Cite this

@article{5f163cc435214c99b5d80af357d99f49,

title = "Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: The MESA study",

abstract = "Sleep disordered breathing (SDB) is a common condition increasingly recognized as a risk factor for atrial fibrillation (AF).1,2 Long P wave duration, an electrocardiographic (ECG) marker of atrial remodelling, was shown in patients with SDB highlighting the potential role of atrial remodelling in linking SDB to AF.3 This study was limited by small sample sizes of selected patients from sleep clinics. Emerging literature indicates that an ECG marker for P wave terminal force (PTF) identifies atrial abnormalities strongly linked to AF and stroke.4 However, the association between PTF and SDB has not been explored previously. Therefore, we sought to examine the association of ECG markers of left atrial (LA) abnormalities in relation to SDB in a large, representative population in this study, with a specific interest in PTF in V1(PTFV1) as a sensitive marker of LA abnormalities.",

keywords = "Atrial fibrillation, Epidemiology, P wave index, P wave terminal force, Sleep apnoe, Sleep disordered breathing",

author = "Younghoon Kwon and Misialek, {Jeffrey R.} and Daniel Duprez and Alvaro Alonso and Jacobs, {David R.} and Heckbert, {Susan R.} and Susan Redline and Soliman, {Elsayed Z.}",

note = "Funding Information: This research was supported by contracts N01 HC 95159, N01 HC 95160, N01 HC 95161, N01 HC 95162, N01 HC 95163, N01 HC 95164, N01 HC 95165, N01 HC 95166, N01 HC 95167, N01 HC 95168 and N01 HC 95169 from the NHBLI, by grants UL1 TR 000040, UL1 RR 025005 from NCRR, R01HL098433 (MESA Sleep) and T32 HL069764. Publisher Copyright: {\textcopyright} The Author 2016. For permissions.",

year = "2017",

month = nov,

day = "1",

doi = "10.1093/europace/euw328",

language = "English (US)",

volume = "19",

pages = "1759--1766",

journal = "Europace",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "11",

}

TY - JOUR

T1 - Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities

T2 - The MESA study

AU - Kwon, Younghoon

AU - Misialek, Jeffrey R.

AU - Duprez, Daniel

AU - Alonso, Alvaro

AU - Jacobs, David R.

AU - Heckbert, Susan R.

AU - Redline, Susan

AU - Soliman, Elsayed Z.

N1 - Funding Information: This research was supported by contracts N01 HC 95159, N01 HC 95160, N01 HC 95161, N01 HC 95162, N01 HC 95163, N01 HC 95164, N01 HC 95165, N01 HC 95166, N01 HC 95167, N01 HC 95168 and N01 HC 95169 from the NHBLI, by grants UL1 TR 000040, UL1 RR 025005 from NCRR, R01HL098433 (MESA Sleep) and T32 HL069764. Publisher Copyright: © The Author 2016. For permissions.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Sleep disordered breathing (SDB) is a common condition increasingly recognized as a risk factor for atrial fibrillation (AF).1,2 Long P wave duration, an electrocardiographic (ECG) marker of atrial remodelling, was shown in patients with SDB highlighting the potential role of atrial remodelling in linking SDB to AF.3 This study was limited by small sample sizes of selected patients from sleep clinics. Emerging literature indicates that an ECG marker for P wave terminal force (PTF) identifies atrial abnormalities strongly linked to AF and stroke.4 However, the association between PTF and SDB has not been explored previously. Therefore, we sought to examine the association of ECG markers of left atrial (LA) abnormalities in relation to SDB in a large, representative population in this study, with a specific interest in PTF in V1(PTFV1) as a sensitive marker of LA abnormalities.

AB - Sleep disordered breathing (SDB) is a common condition increasingly recognized as a risk factor for atrial fibrillation (AF).1,2 Long P wave duration, an electrocardiographic (ECG) marker of atrial remodelling, was shown in patients with SDB highlighting the potential role of atrial remodelling in linking SDB to AF.3 This study was limited by small sample sizes of selected patients from sleep clinics. Emerging literature indicates that an ECG marker for P wave terminal force (PTF) identifies atrial abnormalities strongly linked to AF and stroke.4 However, the association between PTF and SDB has not been explored previously. Therefore, we sought to examine the association of ECG markers of left atrial (LA) abnormalities in relation to SDB in a large, representative population in this study, with a specific interest in PTF in V1(PTFV1) as a sensitive marker of LA abnormalities.

KW - Atrial fibrillation

KW - Epidemiology

KW - P wave index

KW - P wave terminal force

KW - Sleep apnoe

KW - Sleep disordered breathing

UR - http://www.scopus.com/inward/record.url?scp=85034820859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034820859&partnerID=8YFLogxK

U2 - 10.1093/europace/euw328

DO - 10.1093/europace/euw328

M3 - Article

C2 - 28017934

AN - SCOPUS:85034820859

VL - 19

SP - 1759

EP - 1766

JO - Europace

JF - Europace

SN - 1099-5129

IS - 11

ER -

Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: The MESA study

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this