Association between serum gamma-glutamyltransferase and C-reactive protein

Duk Hee Lee, David R. Jacobs

Research output: Contribution to journalArticlepeer-review

170 Scopus citations


A series of epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Therefore, we examined the cross-sectional association between deciles of serum GGT and concentrations of serum C-reactive protein (CRP), a marker of chronic inflammation, among 12,110 adult participants in the third U.S. National Health and Nutrition Examination Survey. After adjustment for race, sex, age, cigarette smoking, alcohol intake, and body mass index (BMI), serum concentration of GGT across all deciles was positively associated with serum concentrations of CRP (P for trend < 0.01). For example, adjusted relative risks of serum CRP ≥ 3.0 mg/L by deciles of serum GGT were 1.0, 1.23, 1.40, 1.59, 1.62, 1.61, 2.17, 2.38, 2.45, and 3.41 (P for trend < 0.01). This association was consistently observed among all subgroups; Non-Hispanic White, Non-Hispanic Black, Mexican American, men, women, non-drinkers, drinkers, non-smokers, ex-smokers, current smokers, BMI < 25, BMI 25-29.9, and BMI ≥ 30. The strong association of serum GGT and CRP suggest that further studies on cellular and/or serum GGT might help to elucidate the association between oxidative stress and inflammation.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
Issue number2
StatePublished - Feb 2005

Bibliographical note

Copyright 2008 Elsevier B.V., All rights reserved.


  • C-reactive protein
  • Gamma glutamyltransferase
  • Inflammation
  • Oxidative stress


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