Association between P3 event-related potential amplitude and externalizing disorders: A time-domain and time-frequency investigation of 29-year-old adults

Henry H. Yoon, Steve Malone, Scott J. Burwell, Edward M. Bernat, William G Iacono

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This study determined whether time-domain P3 amplitude and time-frequency principal component (TF-PC) reductions are present in adulthood (age 29) when participants have largely passed through the age of heaviest substance misuse. Participants were assessed from age 17 through 29 for lifetime externalizing (EXT) disorders. EEG comparisons from three topographic regions were examined for P3 amplitude and TF-PCs at delta and theta frequency ranges. Significant P3 amplitude reductions were found in those with EXT for both regional and site-Pz analyses, with stronger effects observed the greater the EXT comorbidity. Reductions were also observed in all eight TF-PCs extracted, with a delta component yielding frontal effects not apparent in the time domain. Overall, results suggest that these brain measures continue, at age 29, to provide effective indices of EXT that potentially tap a neural substrate related to behavioral disinhibition.

Original languageEnglish (US)
Pages (from-to)595-609
Number of pages15
JournalPsychophysiology
Volume50
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Disinhibitory behavioral disorders
  • Externalizing psychopathology
  • P3 amplitude
  • Substance dependence
  • Time-frequency principal components

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