Association between omega-3 fatty acid levels and risk for incident major bleeding events and atrial fibrillation: Mesa

Karan Kapoor, Abdulhamied Alfaddagh, Mahmoud Al Rifai, Deepak L. Bhatt, Matthew J. Budoff, Khurram Nasir, Michael Miller, Francine K. Welty, J. William McEvoy, Zeina Dardari, Michael D. Shapiro, Roger S. Blumenthal, Michael Y. Tsai, Michael J. Blaha

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1 Scopus citations


BACKGROUND: Randomized trials of pharmacologic strength omega-3 fatty acid (n3-FA)– based therapies suggest a dose-dependent cardiovascular benefit. Whether blood n3-FA levels also mediate safety signals observed in these trials, such as increased bleeding and atrial fibrillation (AF), remains uncertain. We hypothesized that higher baseline n3-FA levels would be associated with incident bleeding and AF events in MESA (Multi-Ethnic Study of Atherosclerosis), which included a population free of clinical cardiovascular disease at baseline. METHODS AND RESULTS: We examined the association between baseline plasma n3-FA levels (expressed as percent mass of total fatty acid) with incident bleeding and AF in MESA, an ongoing prospective cohort study. Bleeding events were identified from review of hospitalization International Classification of Diseases, Ninth Revision (ICD-9), and International Classification of Diseases, Tenth Revision (ICD-10), codes, and AF from participant report, discharge diagnoses, Medicare claims data, and study ECGs performed at MESA visit 5. Separate multivariable Cox proportional hazard modeling was used to estimate hazard ratios of the association of continuous n3-FA (log eicosapentaenoic acid [EPA], log docosahexaenoic acid [DHA], log [EPA+DHA]) and incident hospitalized bleeding events and AF. Among 6546 participants, the mean age was 62.1 years and 53% were women. For incident bleeding, consistent statistically significant associations with lower rates were seen with increasing levels of EPA and EPA+DHA in unadjusted and adjusted models including medications that modulate bleeding risk (aspirin, NSAIDS, corticosteroids, and proton pump inhibitors). For incident AF, a significant association with lower rates was seen with increasing levels of DHA, but not for EPA or EPA+DHA. CONCLUSIONS: In MESA, higher plasma levels of n3-FA (EPA and EPA+DHA, but not DHA) were associated with significantly fewer hospitalized bleeding events, and higher DHA levels (but not EPA or EPA+DHA) with fewer incident AF events.

Original languageEnglish (US)
Article numbere021431
JournalJournal of the American Heart Association
Issue number11
StatePublished - Jun 1 2021

Bibliographical note

Funding Information:
Dr Blaha discloses the following relationships—advisory board/consulting: Amgen, Sanofi, Regeneron, Novartis, Novo Nordisk, Bayer, Akcea Therapeutics, 89Bio, Zogenix, Tricida, Gilead; grants: National Institutes of Health; American Heart Association; Aetna Foundation, and Amgen Foundation. Dr Bhatt discloses the following relationships—advisory board: Cardax, CellProthera, Cereno Scientific, Elsevier Practice Update Cardiology, Level Ex, Medscape Cardiology, PhaseBio, PLx Pharma, Regado Biosciences; board of directors: Boston VA Research Institute, Society of

Funding Information:
This research was supported by contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences.

Publisher Copyright:
© 2021 Universitatea de Vest Vasile Goldis din Arad. All rights reserved.


  • Arrhythmia
  • Atrial fibrillation
  • Bleeding
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Omega-3

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Research Support, N.I.H., Extramural


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