TY - JOUR
T1 - Association between low-dose aspirin and periodontal disease
T2 - Results from the continuous national health and nutrition examination survey (NHANES) 2011-2012
AU - Kotsakis, Georgios A.
AU - Thai, Ashley
AU - Ioannou, Andreas L.
AU - Demmer, Ryan T.
AU - Michalowicz, Bryan S.
N1 - Publisher Copyright:
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Aim Low-dose aspirin has been hypothesized as being a potential host modulatory agent for periodontitis treatment. We investigated the relationship between low-dose aspirin use and periodontitis prevalence in the continuous National Health and Nutrition Examination Survey, 2011-2012. Methods We analysed n = 2335 adult men and women who received a full-mouth periodontal examination and responded to an aspirin use questionnaire. Periodontal disease was defined as severe, moderate or mild according to established case definitions. Mean full-mouth probing depth, attachment loss and tooth loss were also considered. Low-dose aspirin was defined by any self-reported, physician prescribed aspirin use of ≤162 mg/day. Results Participants had mean age (SE) 55.8 years (0.42). The prevalences of periodontitis and low-dose aspirin use were 49.5% and 25% respectively. In multivariable logistic regression models controlling for age, sex, race, socioeconomic variables and comorbidities, the odds ratios [95%CI] for moderate or severe periodontitis among low-dose aspirin users (versus non-users) were: 0.91 [0.56-1.50] and 1.06 [0.74-1.50] respectively. Results were unchanged among participants without diabetes or coronary heart disease. Conclusions Within the limitations of this cross-sectional study we conclude that low-dose aspirin is not associated with prevalent periodontal status in a nationally representative sample of US adults.
AB - Aim Low-dose aspirin has been hypothesized as being a potential host modulatory agent for periodontitis treatment. We investigated the relationship between low-dose aspirin use and periodontitis prevalence in the continuous National Health and Nutrition Examination Survey, 2011-2012. Methods We analysed n = 2335 adult men and women who received a full-mouth periodontal examination and responded to an aspirin use questionnaire. Periodontal disease was defined as severe, moderate or mild according to established case definitions. Mean full-mouth probing depth, attachment loss and tooth loss were also considered. Low-dose aspirin was defined by any self-reported, physician prescribed aspirin use of ≤162 mg/day. Results Participants had mean age (SE) 55.8 years (0.42). The prevalences of periodontitis and low-dose aspirin use were 49.5% and 25% respectively. In multivariable logistic regression models controlling for age, sex, race, socioeconomic variables and comorbidities, the odds ratios [95%CI] for moderate or severe periodontitis among low-dose aspirin users (versus non-users) were: 0.91 [0.56-1.50] and 1.06 [0.74-1.50] respectively. Results were unchanged among participants without diabetes or coronary heart disease. Conclusions Within the limitations of this cross-sectional study we conclude that low-dose aspirin is not associated with prevalent periodontal status in a nationally representative sample of US adults.
KW - aspirin
KW - epidemiology
KW - host modulation therapy
KW - national health and nutrition examination survey
KW - periodontal diseases
KW - periodontitis
UR - http://www.scopus.com/inward/record.url?scp=84927787039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927787039&partnerID=8YFLogxK
U2 - 10.1111/jcpe.12380
DO - 10.1111/jcpe.12380
M3 - Review article
C2 - 25683058
AN - SCOPUS:84927787039
SN - 0303-6979
VL - 42
SP - 333
EP - 341
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 4
ER -