Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study

M. Bradley Drummond; Andrew Edmonds; Catalina Ramirez; Valentina Stosor; Igor Z. Barjaktarevic; Alison Morris; Meredith C. McCormack; Surya P. Bhatt; Maria L. Alcaide; Sushma K. Cribbs; Gypsyamber D'Souza; Neha Bhandari; Ken M. Kunisaki; Laurence Huang; Seble G. Kassaye; Robert Foronjy; Anjali Sharma; Daniel J. Westreich; Adaora A. Adimora

doi:10.1097/QAI.0000000000003088

Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study

M. Bradley Drummond, Andrew Edmonds, Catalina Ramirez, Valentina Stosor, Igor Z. Barjaktarevic, Alison Morris, Meredith C. McCormack, Surya P. Bhatt, Maria L. Alcaide, Sushma K. Cribbs, Gypsyamber D'Souza, Neha Bhandari, Ken M. Kunisaki, Laurence Huang, Seble G. Kassaye, Robert Foronjy, Anjali Sharma, Daniel J. Westreich, Adaora A. Adimora

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background:The association between HIV and asthma prevalence and manifestations remains unclear, with few studies including women.Setting:A retrospective observational cohort study from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study.Methods:Asthma was defined in 2 ways: (1) self-report and (2) robust criteria requiring all the following: lack of fixed airflow obstruction, presence of wheeze on the St. George's Respiratory Questionnaire (SGRQ), and report of asthma therapies. Estimates of asthma prevalence and asthma-related manifestations were compared by HIV serostatus.Results:A total of 1815 men and 2122 women were included. Asthma prevalence did not differ between people with HIV (PWH) and people without HIV regardless of definition: self-report (men, 12.0% vs. 11.2%; women, 24.3% vs. 27.5%) and robust criteria (men, 5.0% vs. 3.4%; women, 12.8% vs. 13.2%). Among men with asthma, worse respiratory symptom burden was reported among those with HIV, regardless of asthma definition. Among women with self-reported asthma, those with HIV had less respiratory symptom burden. Regardless of serostatus, women with robust-defined asthma had similar respiratory symptoms across SGRQ domains and similar frequencies of phlegm, shortness of breath, and wheezing.Conclusions:Among PWH and people without HIV, asthma prevalence was 2-fold to 3-fold higher using self-reported definition rather than robust definition. In men and women, HIV was not associated with increased asthma prevalence. In men, HIV was associated with more respiratory symptoms when asthma was self-reported; the relationship was attenuated with the robust criteria. Further studies are needed to explore asthma phenotypes among PWH.

Original language	English (US)
Pages (from-to)	419-428
Number of pages	10
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	91
Issue number	5
DOIs	https://doi.org/10.1097/QAI.0000000000003088
State	Published - Dec 15 2022
Externally published	Yes

Bibliographical note

Funding Information:
Supported by grants from the National Institutes of Health (see acknowledgments statement for list of grants). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH) or Department of Veterans Affairs.

Funding Information:
Data in this manuscript were collected by the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange, and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM).

Publisher Copyright:
© 2022 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

HIV
asthma
lung diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1097/QAI.0000000000003088

Find It

Find It at U of M Libraries

Cite this

Bradley Drummond, M., Edmonds, A., Ramirez, C., Stosor, V., Barjaktarevic, I. Z., Morris, A., McCormack, M. C., Bhatt, S. P., Alcaide, M. L., Cribbs, S. K., D'Souza, G., Bhandari, N., Kunisaki, K. M., Huang, L., Kassaye, S. G., Foronjy, R., Sharma, A., Westreich, D. J., & Adimora, A. A. (2022). Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. Journal of Acquired Immune Deficiency Syndromes, 91(5), 419-428. https://doi.org/10.1097/QAI.0000000000003088

Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. / Bradley Drummond, M.; Edmonds, Andrew; Ramirez, Catalina et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 91, No. 5, 15.12.2022, p. 419-428.

Research output: Contribution to journal › Article › peer-review

Bradley Drummond, M, Edmonds, A, Ramirez, C, Stosor, V, Barjaktarevic, IZ, Morris, A, McCormack, MC, Bhatt, SP, Alcaide, ML, Cribbs, SK, D'Souza, G, Bhandari, N, Kunisaki, KM, Huang, L, Kassaye, SG, Foronjy, R, Sharma, A, Westreich, DJ & Adimora, AA 2022, 'Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study', Journal of Acquired Immune Deficiency Syndromes, vol. 91, no. 5, pp. 419-428. https://doi.org/10.1097/QAI.0000000000003088

@article{5bac7adb1577478fbf7555771bb06c9c,

title = "Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study",

abstract = "Background:The association between HIV and asthma prevalence and manifestations remains unclear, with few studies including women.Setting:A retrospective observational cohort study from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study.Methods:Asthma was defined in 2 ways: (1) self-report and (2) robust criteria requiring all the following: lack of fixed airflow obstruction, presence of wheeze on the St. George's Respiratory Questionnaire (SGRQ), and report of asthma therapies. Estimates of asthma prevalence and asthma-related manifestations were compared by HIV serostatus.Results:A total of 1815 men and 2122 women were included. Asthma prevalence did not differ between people with HIV (PWH) and people without HIV regardless of definition: self-report (men, 12.0% vs. 11.2%; women, 24.3% vs. 27.5%) and robust criteria (men, 5.0% vs. 3.4%; women, 12.8% vs. 13.2%). Among men with asthma, worse respiratory symptom burden was reported among those with HIV, regardless of asthma definition. Among women with self-reported asthma, those with HIV had less respiratory symptom burden. Regardless of serostatus, women with robust-defined asthma had similar respiratory symptoms across SGRQ domains and similar frequencies of phlegm, shortness of breath, and wheezing.Conclusions:Among PWH and people without HIV, asthma prevalence was 2-fold to 3-fold higher using self-reported definition rather than robust definition. In men and women, HIV was not associated with increased asthma prevalence. In men, HIV was associated with more respiratory symptoms when asthma was self-reported; the relationship was attenuated with the robust criteria. Further studies are needed to explore asthma phenotypes among PWH.",

keywords = "HIV, asthma, lung diseases",

author = "{Bradley Drummond}, M. and Andrew Edmonds and Catalina Ramirez and Valentina Stosor and Barjaktarevic, {Igor Z.} and Alison Morris and McCormack, {Meredith C.} and Bhatt, {Surya P.} and Alcaide, {Maria L.} and Cribbs, {Sushma K.} and Gypsyamber D'Souza and Neha Bhandari and Kunisaki, {Ken M.} and Laurence Huang and Kassaye, {Seble G.} and Robert Foronjy and Anjali Sharma and Westreich, {Daniel J.} and Adimora, {Adaora A.}",

note = "Funding Information: Supported by grants from the National Institutes of Health (see acknowledgments statement for list of grants). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH) or Department of Veterans Affairs. Funding Information: Data in this manuscript were collected by the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange, and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM). Publisher Copyright: {\textcopyright} 2022 Wolters Kluwer Health, Inc. All rights reserved.",

year = "2022",

month = dec,

day = "15",

doi = "10.1097/QAI.0000000000003088",

language = "English (US)",

volume = "91",

pages = "419--428",

journal = "Journal of Acquired Immune Deficiency Syndromes",

issn = "1525-4135",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Association Between HIV and Prevalence and Manifestations of Asthma

T2 - Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study

AU - Bradley Drummond, M.

AU - Edmonds, Andrew

AU - Ramirez, Catalina

AU - Stosor, Valentina

AU - Barjaktarevic, Igor Z.

AU - Morris, Alison

AU - McCormack, Meredith C.

AU - Bhatt, Surya P.

AU - Alcaide, Maria L.

AU - Cribbs, Sushma K.

AU - D'Souza, Gypsyamber

AU - Bhandari, Neha

AU - Kunisaki, Ken M.

AU - Huang, Laurence

AU - Kassaye, Seble G.

AU - Foronjy, Robert

AU - Sharma, Anjali

AU - Westreich, Daniel J.

AU - Adimora, Adaora A.

N1 - Funding Information: Supported by grants from the National Institutes of Health (see acknowledgments statement for list of grants). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH) or Department of Veterans Affairs. Funding Information: Data in this manuscript were collected by the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange, and Elizabeth Golub), U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Los Angeles CRS (Roger Detels and Matthew Mimiaga), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Martinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01-HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1-TR000004 (UCSF CTSA), UL1-TR003098 (JHU ICTR), UL1-TR001881 (UCLA CTSI), P30-AI-050409 (Atlanta CFAR), P30-AI-073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI-027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM). Publisher Copyright: © 2022 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2022/12/15

Y1 - 2022/12/15

N2 - Background:The association between HIV and asthma prevalence and manifestations remains unclear, with few studies including women.Setting:A retrospective observational cohort study from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study.Methods:Asthma was defined in 2 ways: (1) self-report and (2) robust criteria requiring all the following: lack of fixed airflow obstruction, presence of wheeze on the St. George's Respiratory Questionnaire (SGRQ), and report of asthma therapies. Estimates of asthma prevalence and asthma-related manifestations were compared by HIV serostatus.Results:A total of 1815 men and 2122 women were included. Asthma prevalence did not differ between people with HIV (PWH) and people without HIV regardless of definition: self-report (men, 12.0% vs. 11.2%; women, 24.3% vs. 27.5%) and robust criteria (men, 5.0% vs. 3.4%; women, 12.8% vs. 13.2%). Among men with asthma, worse respiratory symptom burden was reported among those with HIV, regardless of asthma definition. Among women with self-reported asthma, those with HIV had less respiratory symptom burden. Regardless of serostatus, women with robust-defined asthma had similar respiratory symptoms across SGRQ domains and similar frequencies of phlegm, shortness of breath, and wheezing.Conclusions:Among PWH and people without HIV, asthma prevalence was 2-fold to 3-fold higher using self-reported definition rather than robust definition. In men and women, HIV was not associated with increased asthma prevalence. In men, HIV was associated with more respiratory symptoms when asthma was self-reported; the relationship was attenuated with the robust criteria. Further studies are needed to explore asthma phenotypes among PWH.

AB - Background:The association between HIV and asthma prevalence and manifestations remains unclear, with few studies including women.Setting:A retrospective observational cohort study from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study.Methods:Asthma was defined in 2 ways: (1) self-report and (2) robust criteria requiring all the following: lack of fixed airflow obstruction, presence of wheeze on the St. George's Respiratory Questionnaire (SGRQ), and report of asthma therapies. Estimates of asthma prevalence and asthma-related manifestations were compared by HIV serostatus.Results:A total of 1815 men and 2122 women were included. Asthma prevalence did not differ between people with HIV (PWH) and people without HIV regardless of definition: self-report (men, 12.0% vs. 11.2%; women, 24.3% vs. 27.5%) and robust criteria (men, 5.0% vs. 3.4%; women, 12.8% vs. 13.2%). Among men with asthma, worse respiratory symptom burden was reported among those with HIV, regardless of asthma definition. Among women with self-reported asthma, those with HIV had less respiratory symptom burden. Regardless of serostatus, women with robust-defined asthma had similar respiratory symptoms across SGRQ domains and similar frequencies of phlegm, shortness of breath, and wheezing.Conclusions:Among PWH and people without HIV, asthma prevalence was 2-fold to 3-fold higher using self-reported definition rather than robust definition. In men and women, HIV was not associated with increased asthma prevalence. In men, HIV was associated with more respiratory symptoms when asthma was self-reported; the relationship was attenuated with the robust criteria. Further studies are needed to explore asthma phenotypes among PWH.

KW - HIV

KW - asthma

KW - lung diseases

UR - http://www.scopus.com/inward/record.url?scp=85141891245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141891245&partnerID=8YFLogxK

U2 - 10.1097/QAI.0000000000003088

DO - 10.1097/QAI.0000000000003088

M3 - Article

C2 - 36083508

AN - SCOPUS:85141891245

SN - 1525-4135

VL - 91

SP - 419

EP - 428

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

IS - 5

ER -

Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this