Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis

Michelle Reid, Janice E. Maras, Steven Shea, Alexis C. Wood, Cecilia Castro-Diehl, Dayna A. Johnson, Tianyi Huang, David R Jacobs Jr, Allison Crawford, Marie Pierre St-Onge, Susan Redline

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rationale Although short sleep duration has been linked to unhealthy dietary patterns, little is known about the association of obstructive sleep apnea (OSA), a disorder characterized by sleep fragmentation and diet. Study Objectives Investigate associations between diet quality and OSA in the Multi-Ethnic Study of Atherosclerosis and assess whether reductions in slow-wave sleep (stage N3) and rapid eye movement (REM) sleep are potential mediators for these associations. Methods A diverse population (N = 1813) completed a food frequency questionnaire and underwent Type 2 in-home polysomnography, which included measurement of N3 and REM sleep and apnea-hypopnea index (AHI). Moderate-to-more severe OSA was defined as having an AHI > 15 events/hr. Results Participants were 53.9% female with a mean age of 68.3 (SD 9.1) years. Approximately 33.8% were categorized as having moderate-to-more severe OSA. In adjusted analyses, OSA was associated with lower intakes of whole grains, (β = -0.200, SE = 0.072, p < 0.01), higher intakes of red/processed meat, (β = -0.440, SE = 0.136, p < 0.01), and lower overall diet quality (β = -1.286, SE = 0.535, p = 0.02). Stage N3 sleep partially explained the associations between red/processed meat and overall diet quality score with OSA. Conclusions Moderate-to-more severe OSA is associated with a less healthy dietary profile that is partially explained by reduced N3 sleep. These findings suggest the opportunity to target sleep quality in interventions aimed at improving cardio-metabolic risk factors in patients with OSA.

Original languageEnglish (US)
Article numberzsy194
JournalSleep
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2019

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Sleep Apnea Syndromes
Obstructive Sleep Apnea
Atherosclerosis
Diet
Sleep
Sleep Stages
REM Sleep
Sleep Deprivation
Polysomnography
Apnea
Food
Population

Keywords

  • Alternative Health Eating Index
  • OSA
  • diet quality
  • slow-wave sleep

PubMed: MeSH publication types

  • Journal Article

Cite this

Reid, M., Maras, J. E., Shea, S., Wood, A. C., Castro-Diehl, C., Johnson, D. A., ... Redline, S. (2019). Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis. Sleep, 42(1), [zsy194]. https://doi.org/10.1093/sleep/zsy194

Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis. / Reid, Michelle; Maras, Janice E.; Shea, Steven; Wood, Alexis C.; Castro-Diehl, Cecilia; Johnson, Dayna A.; Huang, Tianyi; Jacobs Jr, David R; Crawford, Allison; St-Onge, Marie Pierre; Redline, Susan.

In: Sleep, Vol. 42, No. 1, zsy194, 01.01.2019.

Research output: Contribution to journalArticle

Reid, M, Maras, JE, Shea, S, Wood, AC, Castro-Diehl, C, Johnson, DA, Huang, T, Jacobs Jr, DR, Crawford, A, St-Onge, MP & Redline, S 2019, 'Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis', Sleep, vol. 42, no. 1, zsy194. https://doi.org/10.1093/sleep/zsy194
Reid M, Maras JE, Shea S, Wood AC, Castro-Diehl C, Johnson DA et al. Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis. Sleep. 2019 Jan 1;42(1). zsy194. https://doi.org/10.1093/sleep/zsy194
Reid, Michelle ; Maras, Janice E. ; Shea, Steven ; Wood, Alexis C. ; Castro-Diehl, Cecilia ; Johnson, Dayna A. ; Huang, Tianyi ; Jacobs Jr, David R ; Crawford, Allison ; St-Onge, Marie Pierre ; Redline, Susan. / Association between diet quality and sleep apnea in the Multi-Ethnic Study of Atherosclerosis. In: Sleep. 2019 ; Vol. 42, No. 1.
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abstract = "Rationale Although short sleep duration has been linked to unhealthy dietary patterns, little is known about the association of obstructive sleep apnea (OSA), a disorder characterized by sleep fragmentation and diet. Study Objectives Investigate associations between diet quality and OSA in the Multi-Ethnic Study of Atherosclerosis and assess whether reductions in slow-wave sleep (stage N3) and rapid eye movement (REM) sleep are potential mediators for these associations. Methods A diverse population (N = 1813) completed a food frequency questionnaire and underwent Type 2 in-home polysomnography, which included measurement of N3 and REM sleep and apnea-hypopnea index (AHI). Moderate-to-more severe OSA was defined as having an AHI > 15 events/hr. Results Participants were 53.9{\%} female with a mean age of 68.3 (SD 9.1) years. Approximately 33.8{\%} were categorized as having moderate-to-more severe OSA. In adjusted analyses, OSA was associated with lower intakes of whole grains, (β = -0.200, SE = 0.072, p < 0.01), higher intakes of red/processed meat, (β = -0.440, SE = 0.136, p < 0.01), and lower overall diet quality (β = -1.286, SE = 0.535, p = 0.02). Stage N3 sleep partially explained the associations between red/processed meat and overall diet quality score with OSA. Conclusions Moderate-to-more severe OSA is associated with a less healthy dietary profile that is partially explained by reduced N3 sleep. These findings suggest the opportunity to target sleep quality in interventions aimed at improving cardio-metabolic risk factors in patients with OSA.",
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N2 - Rationale Although short sleep duration has been linked to unhealthy dietary patterns, little is known about the association of obstructive sleep apnea (OSA), a disorder characterized by sleep fragmentation and diet. Study Objectives Investigate associations between diet quality and OSA in the Multi-Ethnic Study of Atherosclerosis and assess whether reductions in slow-wave sleep (stage N3) and rapid eye movement (REM) sleep are potential mediators for these associations. Methods A diverse population (N = 1813) completed a food frequency questionnaire and underwent Type 2 in-home polysomnography, which included measurement of N3 and REM sleep and apnea-hypopnea index (AHI). Moderate-to-more severe OSA was defined as having an AHI > 15 events/hr. Results Participants were 53.9% female with a mean age of 68.3 (SD 9.1) years. Approximately 33.8% were categorized as having moderate-to-more severe OSA. In adjusted analyses, OSA was associated with lower intakes of whole grains, (β = -0.200, SE = 0.072, p < 0.01), higher intakes of red/processed meat, (β = -0.440, SE = 0.136, p < 0.01), and lower overall diet quality (β = -1.286, SE = 0.535, p = 0.02). Stage N3 sleep partially explained the associations between red/processed meat and overall diet quality score with OSA. Conclusions Moderate-to-more severe OSA is associated with a less healthy dietary profile that is partially explained by reduced N3 sleep. These findings suggest the opportunity to target sleep quality in interventions aimed at improving cardio-metabolic risk factors in patients with OSA.

AB - Rationale Although short sleep duration has been linked to unhealthy dietary patterns, little is known about the association of obstructive sleep apnea (OSA), a disorder characterized by sleep fragmentation and diet. Study Objectives Investigate associations between diet quality and OSA in the Multi-Ethnic Study of Atherosclerosis and assess whether reductions in slow-wave sleep (stage N3) and rapid eye movement (REM) sleep are potential mediators for these associations. Methods A diverse population (N = 1813) completed a food frequency questionnaire and underwent Type 2 in-home polysomnography, which included measurement of N3 and REM sleep and apnea-hypopnea index (AHI). Moderate-to-more severe OSA was defined as having an AHI > 15 events/hr. Results Participants were 53.9% female with a mean age of 68.3 (SD 9.1) years. Approximately 33.8% were categorized as having moderate-to-more severe OSA. In adjusted analyses, OSA was associated with lower intakes of whole grains, (β = -0.200, SE = 0.072, p < 0.01), higher intakes of red/processed meat, (β = -0.440, SE = 0.136, p < 0.01), and lower overall diet quality (β = -1.286, SE = 0.535, p = 0.02). Stage N3 sleep partially explained the associations between red/processed meat and overall diet quality score with OSA. Conclusions Moderate-to-more severe OSA is associated with a less healthy dietary profile that is partially explained by reduced N3 sleep. These findings suggest the opportunity to target sleep quality in interventions aimed at improving cardio-metabolic risk factors in patients with OSA.

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