Association between alcohol consumption, folate intake, and risk of pancreatic cancer: A case-control study

Winta Yallew, William R. Bamlet, Ann L. Oberg, Kristin E Anderson, Janet E. Olson, Rashmi Sinha, Gloria M. Petersen, Rachael Z. Stolzenberg-Solomon, Rick J. Jansen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Pancreatic cancer is one of the most fatal common cancers affecting both men and women, representing about 3% of all new cancer cases in the United States. In this study, we aimed to investigate the association of pancreatic cancer risk with alcohol consumption as well as folate intake. We performed a case-control study of 384 patients diagnosed with pancreatic cancer from May 2004 to December 2009 and 983 primary care healthy controls in a largely white population (>96%). Our findings showed no significant association between risk of pancreatic cancer and either overall alcohol consumption or type of alcohol consumed (drinks/day). Our study showed dietary folate intake had a modest effect size, but was significantly inversely associated with pancreatic cancer (odds ratio (OR) = 0.99, p < 0.0001). The current study supports the hypothesis that pancreatic cancer risk is reduced with higher food-based folate intake.

Original languageEnglish (US)
Article number448
Issue number5
StatePublished - May 2017

Bibliographical note

Funding Information:
This study was funded in part by National Cancer Institute grants P50 CA102701 and R25 CA92049.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.


  • Alcohol intake
  • Case-control study
  • Folate intake
  • Pancreatic cancer


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