Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients

Jose D. Debes; Zwier M.A. Groothuismink; Robert A. de Man; Andre Boonstra

doi:10.1002/jmv.26236

Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients

Jose D. Debes, Zwier M.A. Groothuismink, Robert A. de Man, Andre Boonstra

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Problem: We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEV−). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEV−/PROGINS− samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels.

Original language	English (US)
Pages (from-to)	3871-3874
Number of pages	4
Journal	Journal of Medical Virology
Volume	92
Issue number	12
Early online date	Jun 30 2020
DOIs	https://doi.org/10.1002/jmv.26236
State	Published - Dec 1 2020

Bibliographical note

Funding Information:
Supported by the American College of Gastroenterology (ACG‐CR‐033‐2016), Robert Wood Johnson Foundation (AMFDP), and NIH‐NCI R21 CA215883‐01A1 all to JDD.

Funding Information:
Supported by the American College of Gastroenterology (ACG-CR-033-2016), Robert Wood Johnson Foundation (AMFDP), and NIH-NCI R21 CA215883-01A1 all to JDD.

Publisher Copyright:
© 2020 Wiley Periodicals LLC

Keywords

HEV
PROGINS
cytokines
liver transplant

PubMed: MeSH publication types

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.26236

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abstract = "Problem: We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEV−). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEV−/PROGINS− samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels.",

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note = "Funding Information: Supported by the American College of Gastroenterology (ACG‐CR‐033‐2016), Robert Wood Johnson Foundation (AMFDP), and NIH‐NCI R21 CA215883‐01A1 all to JDD. Funding Information: Supported by the American College of Gastroenterology (ACG-CR-033-2016), Robert Wood Johnson Foundation (AMFDP), and NIH-NCI R21 CA215883-01A1 all to JDD. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

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N1 - Funding Information: Supported by the American College of Gastroenterology (ACG‐CR‐033‐2016), Robert Wood Johnson Foundation (AMFDP), and NIH‐NCI R21 CA215883‐01A1 all to JDD. Funding Information: Supported by the American College of Gastroenterology (ACG-CR-033-2016), Robert Wood Johnson Foundation (AMFDP), and NIH-NCI R21 CA215883-01A1 all to JDD. Publisher Copyright: © 2020 Wiley Periodicals LLC

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N2 - Problem: We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEV−). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEV−/PROGINS− samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels.

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Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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