Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients

Jose D. Debes, Zwier M.A. Groothuismink, Robert A. de Man, Andre Boonstra

Research output: Contribution to journalArticle

Abstract

Problem: We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEV−). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEV−/PROGINS− samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels.

Original languageEnglish (US)
JournalJournal of Medical Virology
DOIs
StateAccepted/In press - 2020

Keywords

  • cytokines
  • HEV
  • liver transplant
  • PROGINS

PubMed: MeSH publication types

  • Journal Article

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