Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients

Jose D. Debes, Zwier M.A. Groothuismink, Robert A. de Man, Andre Boonstra

Research output: Contribution to journalArticlepeer-review

Abstract

Problem: We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEV−). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEV−/PROGINS− samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels.

Original languageEnglish (US)
Pages (from-to)3871-3874
Number of pages4
JournalJournal of Medical Virology
Volume92
Issue number12
Early online dateJun 30 2020
DOIs
StatePublished - Dec 1 2020

Bibliographical note

Funding Information:
Supported by the American College of Gastroenterology (ACG‐CR‐033‐2016), Robert Wood Johnson Foundation (AMFDP), and NIH‐NCI R21 CA215883‐01A1 all to JDD.

Funding Information:
Supported by the American College of Gastroenterology (ACG-CR-033-2016), Robert Wood Johnson Foundation (AMFDP), and NIH-NCI R21 CA215883-01A1 all to JDD.

Publisher Copyright:
© 2020 Wiley Periodicals LLC

Keywords

  • HEV
  • PROGINS
  • cytokines
  • liver transplant

PubMed: MeSH publication types

  • Journal Article

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