Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Neil Stahl; Teri G. Boulton; Thomas Farruggella; Nancy Y. Ip; Sam Davis; Bruce A. Witthuhn; Frederick W. Quelle; Olli Silvennoinen; Giovanna Barbieri; Sandra Pellegrini; James N. Ihle; George D. Yancopoulos

doi:10.1126/science.8272873

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Neil Stahl, Teri G. Boulton, Thomas Farruggella, Nancy Y. Ip, Sam Davis, Bruce A. Witthuhn, Frederick W. Quelle, Olli Silvennoinen, Giovanna Barbieri, Sandra Pellegrini, James N. Ihle, George D. Yancopoulos

Center for Metabolomics and Proteomics

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916 Scopus citations

Abstract

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

Original language	English (US)
Pages (from-to)	92-95
Number of pages	4
Journal	Science
Volume	263
Issue number	5143
DOIs	https://doi.org/10.1126/science.8272873
State	Published - 1994

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title = "Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components",

abstract = "A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.",

author = "Neil Stahl and Boulton, {Teri G.} and Thomas Farruggella and Ip, {Nancy Y.} and Sam Davis and Witthuhn, {Bruce A.} and Quelle, {Frederick W.} and Olli Silvennoinen and Giovanna Barbieri and Sandra Pellegrini and Ihle, {James N.} and Yancopoulos, {George D.}",

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AU - Stahl, Neil

AU - Boulton, Teri G.

AU - Farruggella, Thomas

AU - Ip, Nancy Y.

AU - Davis, Sam

AU - Witthuhn, Bruce A.

AU - Quelle, Frederick W.

AU - Silvennoinen, Olli

AU - Barbieri, Giovanna

AU - Pellegrini, Sandra

AU - Ihle, James N.

AU - Yancopoulos, George D.

PY - 1994

Y1 - 1994

N2 - A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

AB - A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

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JF - Science

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ER -

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Abstract

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