Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 β receptor components

Neil Stahl, Teri G. Boulton, Thomas Farruggella, Nancy Y. Ip, Sam Davis, Bruce A. Witthuhn, Frederick W. Quelle, Olli Silvennoinen, Giovanna Barbieri, Sandra Pellegrini, James N. Ihle, George D. Yancopoulos

Research output: Contribution to journalArticlepeer-review

809 Scopus citations

Abstract

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The β receptor components for this cytokine family, gp130 and LIF receptor β, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor β components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
JournalScience
Volume263
Issue number5143
DOIs
StatePublished - 1994
Externally publishedYes

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