Assisted reproductive technology use and outcomes among women with a history of cancer

Barbara Luke, Morton B. Brown, Stacey A. Missmer, Logan G. Spector, Richard E. Leach, Melanie Williams, Lori Koch, Yolanda R. Smith, Judy E. Stern, G. David Ball, Maria J. Schymura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Study question: How do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to women without cancer? summaryanswer: The likelihood of a live birth afterARTamongwomenwith prior cancer using autologous oocytes is reduced and varies by cancer diagnosis but is similar to women without cancer when donor oocytes are used. what is known already: Premenopausal patients faced with a cancer diagnosis frequently present for fertility preservation. study design, size, duration: Population-based cohort study of women treated with ART in NY, TX and IL, USA. participants/materials, setting, methods: Women with their first ART treatment between 2004 and 2009 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database and linked to their respective State Cancer Registries based on name, date of birth and social security number. Years were rounded, i.e. year 1 = 6-18 months before treatment. This study used reports of cancer from5 years, 6 months prior to treatment until 6 months after firstARTtreatment.Women who only presented for embryo bankingwere omitted from the analysis. The likelihood of pregnancy and of live birth withARTusing autologous oocyteswas modeled using logistic regression, with women without prior cancer as the reference group, adjusted for woman's age, parity, cumulative FSH dosage, infertility diagnosis, number of diagnoses, numberofARTcycles, State of residency and year ofARTtreatment. Results of the modeling are reported as adjusted odds ratios (AORs) and (95% confidence intervals). main results and the role of chance: The study population included 53 426 women; 441 womenwere diagnosed with cancer within 5 years prior toARTcycle start.Mean(±SD) age at cancer diagnosiswas 33.4±5.7 years; age at start ofARTtreatmentwas34.9±5.8 for women with cancer compared with 35.3±5.3 years for women without cancer (P = 0.03). Live birth rates among women using autologous oocytes differed substantially by cancer status (47.7% without cancer versus 24.7% with cancer, P < 0.0001), and cancer diagnosis (ranging from53.5% for melanomato 14.3% for breast cancer, P < 0.0001. The live birth rates amongwomenusing donor oocytes did not vary significantly by cancer status (60.4% forwomenwith any cancer versus64.5%forwomenwithout cancer), or by cancer diagnosis (ranging from57.9%for breast cancer to 63.6% for endocrine cancer).Women with breast cancer make up about one-third of all cancers in this cohort. Among women with breast cancer, 2.8% of the 106 women who underwent ART within 6 months of being diagnosed with cancer used donor oocytes compared with 34.8% of the 46 women who received ART treatment a longer time after being diagnosed with cancer (P < 0.0001).We conjecture that the former group were either unaware that they had cancer or decided to undergo ART therapy prior to cancer treatment. However, their live birth rate was only 11.7% compared with 28.8%, the overall live birth rate for all women with cancer using autologous oocytes (P < 0.0001). The live birth rate for women diagnosed with breast cancer more than 6 months before ART (23.3%) did not differ significantly from the overall live birth rate for cancer (P = 0.49). If this difference is substantiated by a larger study, it would indicate a negative effect of severe recent illness itself on ART success, rather than the poor outcomebeing only related to the destructive effects of chemotherapies on ovarian follicles. Alternatively, because of the short time difference between cancer diagnosis and ART treatment, these pre-existing cancers may have been detected due to the increased medical surveillance during ART therapy. In women who only used autologous oocytes, women with prior cancers were significantly less likely to become pregnant and to have a live birth than those without cancer (adjusted odds ratio (AOR): 0.34, [95% confidence interval (CI): 0.27, 0.42] and 0.36 [0.28, 0.46], respectively). This was also evident with specific cancer diagnoses: breast cancer (0.20 [0.13, 0.32] and 0.19 [0.11, 0.30], respectively), cervical cancer (0.36 [0.15, 0.87] and 0.33 [0.13, 0.84], respectively) and all female genital cancers (0.49 [0.27, 0.87] and 0.47 [0.25, 0.86], respectively). Of note,amongwomenwith cancerwhobecame pregnant, their likelihood of having a live birth did not differ significantly from women without cancer (85.8 versus 86.7% for women using autologous oocytes, and 85.3 versus 86.9% for women using donor oocytes). limitations, reasons for caution: Women may not have been residents of the individual States for the entire 5-year pre-ART period, and therefore somecancersmaynot havebeen identified through this linkage.As a result, the actual observed numberof cancersmay be an underestimate. In addition, the overall prevalence is low due to the age distributions. Also, because we restricted the pre-ART period to 5 years prior,wewould not have identifiedwomenwhowere survivors of early childhood cancers (younger than age 13 years at cancer diagnosis), orwho had ART more than 5 years after being diagnosed with cancer. Additional analyses are currently underway evaluating live birth outcomes after embryo banking among women with cancer prior to ART, cycles which were excluded from the analyses in this paper. Future studies are planned which will include more States, as well as linkages to vital records to obtain information on spontaneous conceptions and births, to further clarify some of the issues raised in this analysis. wider implications of the findings: Since the live birth rates using donor oocytes were not reduced in women with a prior cancer, but were reduced with autologous cycles, this suggests that factors acting in the pre- or peri-conceptional periods may be responsible for the decline. study funding/competing interests: The study was funded by grant R01 CA151973 from the National Cancer Institute, National Institutes of Health, USA. B.L. is a research consultant for the Society for Assisted Reproductive Technology. All other authors report no conflict of interest.

Original languageEnglish (US)
Pages (from-to)183-189
Number of pages7
JournalHuman Reproduction
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Assisted Reproductive Techniques
Neoplasms
Live Birth
Oocytes
Birth Rate
Breast Neoplasms
Tissue Donors

Keywords

  • Assisted reproduction
  • Breast cancer
  • Cancer among women
  • Cohort study
  • Live births
  • Oncofertility

Cite this

Luke, B., Brown, M. B., Missmer, S. A., Spector, L. G., Leach, R. E., Williams, M., ... Schymura, M. J. (2016). Assisted reproductive technology use and outcomes among women with a history of cancer. Human Reproduction, 31(1), 183-189. https://doi.org/10.1093/humrep/dev288

Assisted reproductive technology use and outcomes among women with a history of cancer. / Luke, Barbara; Brown, Morton B.; Missmer, Stacey A.; Spector, Logan G.; Leach, Richard E.; Williams, Melanie; Koch, Lori; Smith, Yolanda R.; Stern, Judy E.; Ball, G. David; Schymura, Maria J.

In: Human Reproduction, Vol. 31, No. 1, 01.01.2016, p. 183-189.

Research output: Contribution to journalArticle

Luke, B, Brown, MB, Missmer, SA, Spector, LG, Leach, RE, Williams, M, Koch, L, Smith, YR, Stern, JE, Ball, GD & Schymura, MJ 2016, 'Assisted reproductive technology use and outcomes among women with a history of cancer', Human Reproduction, vol. 31, no. 1, pp. 183-189. https://doi.org/10.1093/humrep/dev288
Luke, Barbara ; Brown, Morton B. ; Missmer, Stacey A. ; Spector, Logan G. ; Leach, Richard E. ; Williams, Melanie ; Koch, Lori ; Smith, Yolanda R. ; Stern, Judy E. ; Ball, G. David ; Schymura, Maria J. / Assisted reproductive technology use and outcomes among women with a history of cancer. In: Human Reproduction. 2016 ; Vol. 31, No. 1. pp. 183-189.
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title = "Assisted reproductive technology use and outcomes among women with a history of cancer",
abstract = "Study question: How do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to women without cancer? summaryanswer: The likelihood of a live birth afterARTamongwomenwith prior cancer using autologous oocytes is reduced and varies by cancer diagnosis but is similar to women without cancer when donor oocytes are used. what is known already: Premenopausal patients faced with a cancer diagnosis frequently present for fertility preservation. study design, size, duration: Population-based cohort study of women treated with ART in NY, TX and IL, USA. participants/materials, setting, methods: Women with their first ART treatment between 2004 and 2009 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database and linked to their respective State Cancer Registries based on name, date of birth and social security number. Years were rounded, i.e. year 1 = 6-18 months before treatment. This study used reports of cancer from5 years, 6 months prior to treatment until 6 months after firstARTtreatment.Women who only presented for embryo bankingwere omitted from the analysis. The likelihood of pregnancy and of live birth withARTusing autologous oocyteswas modeled using logistic regression, with women without prior cancer as the reference group, adjusted for woman's age, parity, cumulative FSH dosage, infertility diagnosis, number of diagnoses, numberofARTcycles, State of residency and year ofARTtreatment. Results of the modeling are reported as adjusted odds ratios (AORs) and (95{\%} confidence intervals). main results and the role of chance: The study population included 53 426 women; 441 womenwere diagnosed with cancer within 5 years prior toARTcycle start.Mean(±SD) age at cancer diagnosiswas 33.4±5.7 years; age at start ofARTtreatmentwas34.9±5.8 for women with cancer compared with 35.3±5.3 years for women without cancer (P = 0.03). Live birth rates among women using autologous oocytes differed substantially by cancer status (47.7{\%} without cancer versus 24.7{\%} with cancer, P < 0.0001), and cancer diagnosis (ranging from53.5{\%} for melanomato 14.3{\%} for breast cancer, P < 0.0001. The live birth rates amongwomenusing donor oocytes did not vary significantly by cancer status (60.4{\%} forwomenwith any cancer versus64.5{\%}forwomenwithout cancer), or by cancer diagnosis (ranging from57.9{\%}for breast cancer to 63.6{\%} for endocrine cancer).Women with breast cancer make up about one-third of all cancers in this cohort. Among women with breast cancer, 2.8{\%} of the 106 women who underwent ART within 6 months of being diagnosed with cancer used donor oocytes compared with 34.8{\%} of the 46 women who received ART treatment a longer time after being diagnosed with cancer (P < 0.0001).We conjecture that the former group were either unaware that they had cancer or decided to undergo ART therapy prior to cancer treatment. However, their live birth rate was only 11.7{\%} compared with 28.8{\%}, the overall live birth rate for all women with cancer using autologous oocytes (P < 0.0001). The live birth rate for women diagnosed with breast cancer more than 6 months before ART (23.3{\%}) did not differ significantly from the overall live birth rate for cancer (P = 0.49). If this difference is substantiated by a larger study, it would indicate a negative effect of severe recent illness itself on ART success, rather than the poor outcomebeing only related to the destructive effects of chemotherapies on ovarian follicles. Alternatively, because of the short time difference between cancer diagnosis and ART treatment, these pre-existing cancers may have been detected due to the increased medical surveillance during ART therapy. In women who only used autologous oocytes, women with prior cancers were significantly less likely to become pregnant and to have a live birth than those without cancer (adjusted odds ratio (AOR): 0.34, [95{\%} confidence interval (CI): 0.27, 0.42] and 0.36 [0.28, 0.46], respectively). This was also evident with specific cancer diagnoses: breast cancer (0.20 [0.13, 0.32] and 0.19 [0.11, 0.30], respectively), cervical cancer (0.36 [0.15, 0.87] and 0.33 [0.13, 0.84], respectively) and all female genital cancers (0.49 [0.27, 0.87] and 0.47 [0.25, 0.86], respectively). Of note,amongwomenwith cancerwhobecame pregnant, their likelihood of having a live birth did not differ significantly from women without cancer (85.8 versus 86.7{\%} for women using autologous oocytes, and 85.3 versus 86.9{\%} for women using donor oocytes). limitations, reasons for caution: Women may not have been residents of the individual States for the entire 5-year pre-ART period, and therefore somecancersmaynot havebeen identified through this linkage.As a result, the actual observed numberof cancersmay be an underestimate. In addition, the overall prevalence is low due to the age distributions. Also, because we restricted the pre-ART period to 5 years prior,wewould not have identifiedwomenwhowere survivors of early childhood cancers (younger than age 13 years at cancer diagnosis), orwho had ART more than 5 years after being diagnosed with cancer. Additional analyses are currently underway evaluating live birth outcomes after embryo banking among women with cancer prior to ART, cycles which were excluded from the analyses in this paper. Future studies are planned which will include more States, as well as linkages to vital records to obtain information on spontaneous conceptions and births, to further clarify some of the issues raised in this analysis. wider implications of the findings: Since the live birth rates using donor oocytes were not reduced in women with a prior cancer, but were reduced with autologous cycles, this suggests that factors acting in the pre- or peri-conceptional periods may be responsible for the decline. study funding/competing interests: The study was funded by grant R01 CA151973 from the National Cancer Institute, National Institutes of Health, USA. B.L. is a research consultant for the Society for Assisted Reproductive Technology. All other authors report no conflict of interest.",
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T1 - Assisted reproductive technology use and outcomes among women with a history of cancer

AU - Luke, Barbara

AU - Brown, Morton B.

AU - Missmer, Stacey A.

AU - Spector, Logan G.

AU - Leach, Richard E.

AU - Williams, Melanie

AU - Koch, Lori

AU - Smith, Yolanda R.

AU - Stern, Judy E.

AU - Ball, G. David

AU - Schymura, Maria J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Study question: How do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to women without cancer? summaryanswer: The likelihood of a live birth afterARTamongwomenwith prior cancer using autologous oocytes is reduced and varies by cancer diagnosis but is similar to women without cancer when donor oocytes are used. what is known already: Premenopausal patients faced with a cancer diagnosis frequently present for fertility preservation. study design, size, duration: Population-based cohort study of women treated with ART in NY, TX and IL, USA. participants/materials, setting, methods: Women with their first ART treatment between 2004 and 2009 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database and linked to their respective State Cancer Registries based on name, date of birth and social security number. Years were rounded, i.e. year 1 = 6-18 months before treatment. This study used reports of cancer from5 years, 6 months prior to treatment until 6 months after firstARTtreatment.Women who only presented for embryo bankingwere omitted from the analysis. The likelihood of pregnancy and of live birth withARTusing autologous oocyteswas modeled using logistic regression, with women without prior cancer as the reference group, adjusted for woman's age, parity, cumulative FSH dosage, infertility diagnosis, number of diagnoses, numberofARTcycles, State of residency and year ofARTtreatment. Results of the modeling are reported as adjusted odds ratios (AORs) and (95% confidence intervals). main results and the role of chance: The study population included 53 426 women; 441 womenwere diagnosed with cancer within 5 years prior toARTcycle start.Mean(±SD) age at cancer diagnosiswas 33.4±5.7 years; age at start ofARTtreatmentwas34.9±5.8 for women with cancer compared with 35.3±5.3 years for women without cancer (P = 0.03). Live birth rates among women using autologous oocytes differed substantially by cancer status (47.7% without cancer versus 24.7% with cancer, P < 0.0001), and cancer diagnosis (ranging from53.5% for melanomato 14.3% for breast cancer, P < 0.0001. The live birth rates amongwomenusing donor oocytes did not vary significantly by cancer status (60.4% forwomenwith any cancer versus64.5%forwomenwithout cancer), or by cancer diagnosis (ranging from57.9%for breast cancer to 63.6% for endocrine cancer).Women with breast cancer make up about one-third of all cancers in this cohort. Among women with breast cancer, 2.8% of the 106 women who underwent ART within 6 months of being diagnosed with cancer used donor oocytes compared with 34.8% of the 46 women who received ART treatment a longer time after being diagnosed with cancer (P < 0.0001).We conjecture that the former group were either unaware that they had cancer or decided to undergo ART therapy prior to cancer treatment. However, their live birth rate was only 11.7% compared with 28.8%, the overall live birth rate for all women with cancer using autologous oocytes (P < 0.0001). The live birth rate for women diagnosed with breast cancer more than 6 months before ART (23.3%) did not differ significantly from the overall live birth rate for cancer (P = 0.49). If this difference is substantiated by a larger study, it would indicate a negative effect of severe recent illness itself on ART success, rather than the poor outcomebeing only related to the destructive effects of chemotherapies on ovarian follicles. Alternatively, because of the short time difference between cancer diagnosis and ART treatment, these pre-existing cancers may have been detected due to the increased medical surveillance during ART therapy. In women who only used autologous oocytes, women with prior cancers were significantly less likely to become pregnant and to have a live birth than those without cancer (adjusted odds ratio (AOR): 0.34, [95% confidence interval (CI): 0.27, 0.42] and 0.36 [0.28, 0.46], respectively). This was also evident with specific cancer diagnoses: breast cancer (0.20 [0.13, 0.32] and 0.19 [0.11, 0.30], respectively), cervical cancer (0.36 [0.15, 0.87] and 0.33 [0.13, 0.84], respectively) and all female genital cancers (0.49 [0.27, 0.87] and 0.47 [0.25, 0.86], respectively). Of note,amongwomenwith cancerwhobecame pregnant, their likelihood of having a live birth did not differ significantly from women without cancer (85.8 versus 86.7% for women using autologous oocytes, and 85.3 versus 86.9% for women using donor oocytes). limitations, reasons for caution: Women may not have been residents of the individual States for the entire 5-year pre-ART period, and therefore somecancersmaynot havebeen identified through this linkage.As a result, the actual observed numberof cancersmay be an underestimate. In addition, the overall prevalence is low due to the age distributions. Also, because we restricted the pre-ART period to 5 years prior,wewould not have identifiedwomenwhowere survivors of early childhood cancers (younger than age 13 years at cancer diagnosis), orwho had ART more than 5 years after being diagnosed with cancer. Additional analyses are currently underway evaluating live birth outcomes after embryo banking among women with cancer prior to ART, cycles which were excluded from the analyses in this paper. Future studies are planned which will include more States, as well as linkages to vital records to obtain information on spontaneous conceptions and births, to further clarify some of the issues raised in this analysis. wider implications of the findings: Since the live birth rates using donor oocytes were not reduced in women with a prior cancer, but were reduced with autologous cycles, this suggests that factors acting in the pre- or peri-conceptional periods may be responsible for the decline. study funding/competing interests: The study was funded by grant R01 CA151973 from the National Cancer Institute, National Institutes of Health, USA. B.L. is a research consultant for the Society for Assisted Reproductive Technology. All other authors report no conflict of interest.

AB - Study question: How do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to women without cancer? summaryanswer: The likelihood of a live birth afterARTamongwomenwith prior cancer using autologous oocytes is reduced and varies by cancer diagnosis but is similar to women without cancer when donor oocytes are used. what is known already: Premenopausal patients faced with a cancer diagnosis frequently present for fertility preservation. study design, size, duration: Population-based cohort study of women treated with ART in NY, TX and IL, USA. participants/materials, setting, methods: Women with their first ART treatment between 2004 and 2009 were identified from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database and linked to their respective State Cancer Registries based on name, date of birth and social security number. Years were rounded, i.e. year 1 = 6-18 months before treatment. This study used reports of cancer from5 years, 6 months prior to treatment until 6 months after firstARTtreatment.Women who only presented for embryo bankingwere omitted from the analysis. The likelihood of pregnancy and of live birth withARTusing autologous oocyteswas modeled using logistic regression, with women without prior cancer as the reference group, adjusted for woman's age, parity, cumulative FSH dosage, infertility diagnosis, number of diagnoses, numberofARTcycles, State of residency and year ofARTtreatment. Results of the modeling are reported as adjusted odds ratios (AORs) and (95% confidence intervals). main results and the role of chance: The study population included 53 426 women; 441 womenwere diagnosed with cancer within 5 years prior toARTcycle start.Mean(±SD) age at cancer diagnosiswas 33.4±5.7 years; age at start ofARTtreatmentwas34.9±5.8 for women with cancer compared with 35.3±5.3 years for women without cancer (P = 0.03). Live birth rates among women using autologous oocytes differed substantially by cancer status (47.7% without cancer versus 24.7% with cancer, P < 0.0001), and cancer diagnosis (ranging from53.5% for melanomato 14.3% for breast cancer, P < 0.0001. The live birth rates amongwomenusing donor oocytes did not vary significantly by cancer status (60.4% forwomenwith any cancer versus64.5%forwomenwithout cancer), or by cancer diagnosis (ranging from57.9%for breast cancer to 63.6% for endocrine cancer).Women with breast cancer make up about one-third of all cancers in this cohort. Among women with breast cancer, 2.8% of the 106 women who underwent ART within 6 months of being diagnosed with cancer used donor oocytes compared with 34.8% of the 46 women who received ART treatment a longer time after being diagnosed with cancer (P < 0.0001).We conjecture that the former group were either unaware that they had cancer or decided to undergo ART therapy prior to cancer treatment. However, their live birth rate was only 11.7% compared with 28.8%, the overall live birth rate for all women with cancer using autologous oocytes (P < 0.0001). The live birth rate for women diagnosed with breast cancer more than 6 months before ART (23.3%) did not differ significantly from the overall live birth rate for cancer (P = 0.49). If this difference is substantiated by a larger study, it would indicate a negative effect of severe recent illness itself on ART success, rather than the poor outcomebeing only related to the destructive effects of chemotherapies on ovarian follicles. Alternatively, because of the short time difference between cancer diagnosis and ART treatment, these pre-existing cancers may have been detected due to the increased medical surveillance during ART therapy. In women who only used autologous oocytes, women with prior cancers were significantly less likely to become pregnant and to have a live birth than those without cancer (adjusted odds ratio (AOR): 0.34, [95% confidence interval (CI): 0.27, 0.42] and 0.36 [0.28, 0.46], respectively). This was also evident with specific cancer diagnoses: breast cancer (0.20 [0.13, 0.32] and 0.19 [0.11, 0.30], respectively), cervical cancer (0.36 [0.15, 0.87] and 0.33 [0.13, 0.84], respectively) and all female genital cancers (0.49 [0.27, 0.87] and 0.47 [0.25, 0.86], respectively). Of note,amongwomenwith cancerwhobecame pregnant, their likelihood of having a live birth did not differ significantly from women without cancer (85.8 versus 86.7% for women using autologous oocytes, and 85.3 versus 86.9% for women using donor oocytes). limitations, reasons for caution: Women may not have been residents of the individual States for the entire 5-year pre-ART period, and therefore somecancersmaynot havebeen identified through this linkage.As a result, the actual observed numberof cancersmay be an underestimate. In addition, the overall prevalence is low due to the age distributions. Also, because we restricted the pre-ART period to 5 years prior,wewould not have identifiedwomenwhowere survivors of early childhood cancers (younger than age 13 years at cancer diagnosis), orwho had ART more than 5 years after being diagnosed with cancer. Additional analyses are currently underway evaluating live birth outcomes after embryo banking among women with cancer prior to ART, cycles which were excluded from the analyses in this paper. Future studies are planned which will include more States, as well as linkages to vital records to obtain information on spontaneous conceptions and births, to further clarify some of the issues raised in this analysis. wider implications of the findings: Since the live birth rates using donor oocytes were not reduced in women with a prior cancer, but were reduced with autologous cycles, this suggests that factors acting in the pre- or peri-conceptional periods may be responsible for the decline. study funding/competing interests: The study was funded by grant R01 CA151973 from the National Cancer Institute, National Institutes of Health, USA. B.L. is a research consultant for the Society for Assisted Reproductive Technology. All other authors report no conflict of interest.

KW - Assisted reproduction

KW - Breast cancer

KW - Cancer among women

KW - Cohort study

KW - Live births

KW - Oncofertility

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