Assessment of prophylactic haloperidol plasma levels in stable outpatient schizophrenics

M. Garvey, D. S. Wakefield, P. Perry, M. Dysken, R. Mcgraw, P. Laughlin, W. Jordan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Schizophrenic patients taking haloperidol prophylactically were screened for a haloperidol monitoring project at four medical centers. Fifty-five patients participated. Most patients had doses and plasma levels below those found in acute treatment studies; however, a sizeable minority had doses and levels that were greater than was probably needed for prophylaxis. Six percent of patients appeared to be rapid metabolizers. A regression formula was calculated for prediction of haloperidol level from daily dose. There were no apparent differences in dosing practices between two university- affiliated medical centers and two nonaffiliated centers. More research is needed to establish optimal prophylactic haloperidol levels. However, haloperidol monitoring can provide some assistance for choice of dose.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalAnnals of Clinical Psychiatry
Issue number2
StatePublished - Jan 1 1992


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