Assessment of genetic polymorphisms associated with hyperuricemia or gout in the Hmong

Youssef M. Roman, Kathleen A. Culhane-Pera, Jeremiah S Menk, Robert J Straka

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Aim: Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two-to five-fold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB). Methods: In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (SLC22A12, SLC2A9, ABCG2, SLC17A1 and PDZK1). Results: The frequency of seven out of eight risk alleles in the Hmong was significantly different than CEU; six higher and one with lower prevalence. The frequency of three out of eight risk alleles in the Hmong was significantly different than CHB; two higher and one with lower prevalence. Conclusion: Hyperuricemia risk alleles are more prevalent in the Hmong than CEU and CHB.

Original languageEnglish (US)
Pages (from-to)429-440
Number of pages12
JournalPersonalized Medicine
Volume13
Issue number5
DOIs
StatePublished - Sep 2016

Keywords

  • Hmong
  • SNPs
  • hyperuricemia

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