Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes

Charlene E. Goh, Bruno Bohn, Ryan T. Demmer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The significance of the oral microbiome in the generation of the nitric oxide (NO) via the enterosalivary nitrate-nitrite-nitric oxide pathway is increasingly recognized, directly linking the oral microbiome to cardiometabolic outcomes influenced by NO. The objective of this chapter is to outline a strategy of identifying pathway-specific bacterial taxa or predicted genes of interest from 16S rRNA data, specifically in the enterosalivary pathway of nitrate reduction, and analyzing their relationship with cardiometabolic outcomes using multivariable regression models.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages139-160
Number of pages22
Volume2327
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2327
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Bibliographical note

Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

  • Nitrate, Nitrite, Nitric oxide pathway
  • Oral microbiome
  • Pathway activity prediction

PubMed: MeSH publication types

  • Journal Article

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