Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes

Charlene E. Goh; Bruno Bohn; Ryan T. Demmer

doi:10.1007/978-1-0716-1518-8_9

Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes

Charlene E. Goh, Bruno Bohn, Ryan T. Demmer

Epidemiology & Community Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The significance of the oral microbiome in the generation of the nitric oxide (NO) via the enterosalivary nitrate-nitrite-nitric oxide pathway is increasingly recognized, directly linking the oral microbiome to cardiometabolic outcomes influenced by NO. The objective of this chapter is to outline a strategy of identifying pathway-specific bacterial taxa or predicted genes of interest from 16S rRNA data, specifically in the enterosalivary pathway of nitrate reduction, and analyzing their relationship with cardiometabolic outcomes using multivariable regression models.

Original language	English (US)
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	139-160
Number of pages	22
DOIs	https://doi.org/10.1007/978-1-0716-1518-8_9
State	Published - 2021

Publication series

Name	Methods in Molecular Biology
Volume	2327
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Bibliographical note

Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

Nitrate, Nitrite, Nitric oxide pathway
Oral microbiome
Pathway activity prediction

PubMed: MeSH publication types

Journal Article

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10.1007/978-1-0716-1518-8_9

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AB - The significance of the oral microbiome in the generation of the nitric oxide (NO) via the enterosalivary nitrate-nitrite-nitric oxide pathway is increasingly recognized, directly linking the oral microbiome to cardiometabolic outcomes influenced by NO. The objective of this chapter is to outline a strategy of identifying pathway-specific bacterial taxa or predicted genes of interest from 16S rRNA data, specifically in the enterosalivary pathway of nitrate reduction, and analyzing their relationship with cardiometabolic outcomes using multivariable regression models.

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ER -

Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes

Abstract

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