Assessing the dynamic biofilm removal of sulfonated phenolics using CP-OCT

K. Englund, J. Nikrad, Robert S Jones

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Examining the physical mechanisms related to biofilm removal of sulfonated phenolics (SP) is difficult using conventional microscopy techniques. A custom flow cell system integrated with a real time cross polarization optical coherence tomography system investigated the dynamic speed of biofilm removal when oral multi-species biofilms are exposed to SP under sheer stress. The Near infrared 1310-nm CP-OCT system non-destructively imaged fluid immersed oral biofilms at nearly 30 frames/s. This dynamic imaging was able to determine the cohesive and adhesion related disruption of SP on oral biofilms adhering to tooth like surfaces. For multi-species biofilms that are initially grown without the presence of sucrose, the disruption of biofilms on saliva coated hydroxyapatite (HA) is dominated as a adhesive failure at the HA-biofilm interface. For multi-species biofilms that are grown in the presence of sucrose, the disruption is dominated by cohesive disruption followed by adhesive failure. This novel CP-OCT flow cell assay has the potential to examine rapid interactions between anti-biofilm agents and tooth like surfaces.

Original languageEnglish (US)
Title of host publicationLasers in Dentistry XXIII
EditorsDaniel Fried, Peter Rechmann
ISBN (Electronic)9781510605299
StatePublished - 2017
EventLasers in Dentistry XXIII - San Francisco, United States
Duration: Jan 29 2017 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceLasers in Dentistry XXIII
Country/TerritoryUnited States
CitySan Francisco
Period1/29/17 → …

Bibliographical note

Publisher Copyright:
© 2017 SPIE.


  • Biofilm
  • Biofilm Disruption
  • Dentistry
  • Optical Coherence Tomography
  • Sulfonated Phenolics


Dive into the research topics of 'Assessing the dynamic biofilm removal of sulfonated phenolics using CP-OCT'. Together they form a unique fingerprint.

Cite this