Assessing post-traumatic changes in cartilage using T dispersion parameters

Hassaan Elsayed, Jouni Karjalainen, Mikko J. Nissi, Juuso Ketola, Abdul Wahed Kajabi, Victor Casula, Štefan Zbýň, Miika T. Nieminen, Matti Hanni

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Degeneration of cartilage can be studied non-invasively with quantitative MRI. A promising parameter for detecting early osteoarthritis in articular cartilage is T, which can be tuned via the amplitude of the spin-lock pulse. By measuring T at several spin-lock amplitudes, the dispersion of T is obtained. The aim of this study is to find out if the dispersion contains diagnostically relevant information complementary to a T measurement at a single spin-lock amplitude. To this end, five differently acquired dispersion parameters are utilized; A, B, τc, T/T2, and R2 − R. An open dataset of an equine model of post-traumatic cartilage was utilized to assess the T dispersion parameters for the evaluation of cartilage degeneration. Firstly, the parameters were compared for their sensitivity in detecting degenerative changes. Secondly, the relationship of the dispersion parameters to histological and biomechanical reference parameters was studied. Parameters A, T/T2, and R2 − R were found to be sensitive to lesion-induced changes in the cartilage within sample. Strong correlations of several dispersion parameters with optical density, as well as with collagen fibril angle were found. Most of the dispersion parameters correlated strongly with individual T values. The results suggest that dispersion parameters can in some cases provide a more accurate description of the biochemical composition of cartilage as compared to conventional MRI parameters. However, in most cases the information given by the dispersion parameters is more of a refinement than complementary to conventional quantitative MRI.

Original languageEnglish (US)
Pages (from-to)91-101
Number of pages11
JournalMagnetic Resonance Imaging
Volume97
DOIs
StatePublished - Apr 2023

Bibliographical note

Funding Information:
Dr. Marianne Haapea is acknowledged for fruitful discussions. Funding: This work was supported by Jane and Aatos Erkko foundation .

Publisher Copyright:
© 2023 The Authors

Keywords

  • Articular cartilage
  • Correlation time
  • Osteoarthritis
  • Quantitative MRI
  • Relaxation dispersion
  • Relaxation time

Center for Magnetic Resonance Research (CMRR) tags

  • MR

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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