Assessing nanoparticle toxicity

Sara A. Love, Melissa A. Maurer-Jones, John W. Thompson, Yu Shen Lin, Christy L. Haynes

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations

Abstract

Nanoparticle toxicology, an emergent field, works toward establishing the hazard of nanoparticles, and therefore their potential risk, in light of the increased use and likelihood of exposure. Analytical chemists can provide an essential tool kit for the advancement of this field by exploiting expertise in sample complexity and preparation as well as method and technology development. Herein, we discuss experimental considerations for performing in vitro nanoparticle toxicity studies, with a focus on nanoparticle characterization, relevant model cell systems, and toxicity assay choices. Additionally, we present three case studies (of silver, titanium dioxide, and carbon nanotube toxicity) to highlight the important toxicological considerations of these commonly used nanoparticles.

Original languageEnglish (US)
Pages (from-to)181-205
Number of pages25
JournalAnnual Review of Analytical Chemistry
Volume5
DOIs
StatePublished - Jul 1 2012

Keywords

  • assay
  • carbon nanotube
  • characterization
  • in vitro
  • silver
  • titanium dioxide

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