TY - JOUR
T1 - Assessing Herd Immunity in the Elderly Following the Vaccination of School Children with Live Attenuated Trivalent Influenza Vaccine (LAIV)
T2 - A County-Level Analysis
AU - Hull, Harry F.
AU - McBean, Alexander M
AU - Caldwell, Debra
AU - O'Connor, Heidi L
PY - 2010
Y1 - 2010
N2 - Immunizing children could reduce influenza in the elderly. We compared pneumonia and influenza hospitalizations (P&I) and medically attended acute respiratory infections (MAARI) in the Medicare populations in 1 Tennessee and 3 Minnesota counties that immunized school children with live, attenuated influenza vaccine with 4 comparison counties. The P&I rate ratio (RR) of intervention county/comparison county in Tennessee in 2005-06 was 0.74 (95% CI 0.61 - 0.87 which was significantly lower than the previous 5 years. With low influenza activity in 2006-07, P&I RRs for both states were not lower than the pre-intervention years. MAARI RRs in both states did not differ from the pre-intervention periods. Immunizing children against influenza may reduce P&I for the elderly in seasons when influenza outbreaks are severe. Additional study is needed before immunizing children against influenza can be recommended for herd immunity.
AB - Immunizing children could reduce influenza in the elderly. We compared pneumonia and influenza hospitalizations (P&I) and medically attended acute respiratory infections (MAARI) in the Medicare populations in 1 Tennessee and 3 Minnesota counties that immunized school children with live, attenuated influenza vaccine with 4 comparison counties. The P&I rate ratio (RR) of intervention county/comparison county in Tennessee in 2005-06 was 0.74 (95% CI 0.61 - 0.87 which was significantly lower than the previous 5 years. With low influenza activity in 2006-07, P&I RRs for both states were not lower than the pre-intervention years. MAARI RRs in both states did not differ from the pre-intervention periods. Immunizing children against influenza may reduce P&I for the elderly in seasons when influenza outbreaks are severe. Additional study is needed before immunizing children against influenza can be recommended for herd immunity.
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U2 - 10.1016/j.provac.2010.03.017
DO - 10.1016/j.provac.2010.03.017
M3 - Article
AN - SCOPUS:77950620857
SN - 1877-282X
VL - 2
SP - 92
EP - 100
JO - Procedia in Vaccinology
JF - Procedia in Vaccinology
IS - 1
ER -
