Assessing ganglion cell layer topography in human albinism using optical coherence tomography

Erica N. Woertz; Bisola S. Omoba; Taylor M. Dunn; Stephanie J. Chiu; Sina Farsiu; Sasha Strul; C. Gail Summers; Arlene V. Drack; Joseph Carroll

doi:10.1167/iovs.61.3.36

Assessing ganglion cell layer topography in human albinism using optical coherence tomography

Erica N. Woertz, Bisola S. Omoba, Taylor M. Dunn, Stephanie J. Chiu, Sina Farsiu, Sasha Strul, C. Gail Summers, Arlene V. Drack, Joseph Carroll

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

PURPOSE. To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism. METHODS. Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant. RESULTS. GCL and IPL topography varied between participants. The summed AUC in all quadrants was similar between groups for both the GCL (P = 0.84) and IPL (P = 0.08). Both groups showed nasal-temporal asymmetry in the GCL, but only participants with albinism had nasal-temporal asymmetry in the IPL. Nasal-temporal asymmetry was greater in albinism for both the GCL (P < 0.0001) and the IPL (P = 0.0006). The GCL usually comprised a greater percentage of the combined GCL and IPL in controls than in albinism. CONCLUSIONS. The GCL and IPL have greater structural variability than previously reported. GCL and IPL topography are significantly altered in albinism, which suggests differences in the spatial distribution of retinal ganglion cells. This finding provides insight into foveal development and structure-function relationships in foveal hypoplasia.

Original language	English (US)
Article number	36
Journal	Investigative Ophthalmology and Visual Science
Volume	61
Issue number	3
DOIs	https://doi.org/10.1167/iovs.61.3.36
State	Published - Mar 9 2020

Bibliographical note

Funding Information:
Supported by the National Eye Institute, the National Institute of General Medical Sciences, and the National Center for Advancing Translational Science of the National Institutes of Health under award numbers R01EY024969, R01EY017607, P30EY001931, T32GM080202, TL1TR001437, and UL1TR001436. This investigation was conducted in part in a facility constructed with support from a Research Facilities Improvement Program, grant number C06RR016511 from the National Center for Research Resources of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support from Vision for Tomorrow and the Gene and Ruth Posner Foundation.

Publisher Copyright:
Copyright 2020 The Authors.

Keywords

Albinism
Foveal development
Foveal hypoplasia
Ganglion cell layer
Optical coherence tomography
Area Under Curve
Intraocular Pressure
Tomography, Optical Coherence
Humans
Male
Albinism, Ocular/diagnostic imaging
Nerve Fibers/pathology
Case-Control Studies
Young Adult
Algorithms
Image Processing, Computer-Assisted
Visual Fields
Adolescent
Adult
Female
Retinal Ganglion Cells/pathology
Child
Observer Variation

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural

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10.1167/iovs.61.3.36

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title = "Assessing ganglion cell layer topography in human albinism using optical coherence tomography",

abstract = "PURPOSE. To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism. METHODS. Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant. RESULTS. GCL and IPL topography varied between participants. The summed AUC in all quadrants was similar between groups for both the GCL (P = 0.84) and IPL (P = 0.08). Both groups showed nasal-temporal asymmetry in the GCL, but only participants with albinism had nasal-temporal asymmetry in the IPL. Nasal-temporal asymmetry was greater in albinism for both the GCL (P < 0.0001) and the IPL (P = 0.0006). The GCL usually comprised a greater percentage of the combined GCL and IPL in controls than in albinism. CONCLUSIONS. The GCL and IPL have greater structural variability than previously reported. GCL and IPL topography are significantly altered in albinism, which suggests differences in the spatial distribution of retinal ganglion cells. This finding provides insight into foveal development and structure-function relationships in foveal hypoplasia.",

keywords = "Albinism, Foveal development, Foveal hypoplasia, Ganglion cell layer, Optical coherence tomography, Area Under Curve, Intraocular Pressure, Tomography, Optical Coherence, Humans, Male, Albinism, Ocular/diagnostic imaging, Nerve Fibers/pathology, Case-Control Studies, Young Adult, Algorithms, Image Processing, Computer-Assisted, Visual Fields, Adolescent, Adult, Female, Retinal Ganglion Cells/pathology, Child, Observer Variation",

author = "Woertz, {Erica N.} and Omoba, {Bisola S.} and Dunn, {Taylor M.} and Chiu, {Stephanie J.} and Sina Farsiu and Sasha Strul and {Gail Summers}, C. and Drack, {Arlene V.} and Joseph Carroll",

note = "Funding Information: Supported by the National Eye Institute, the National Institute of General Medical Sciences, and the National Center for Advancing Translational Science of the National Institutes of Health under award numbers R01EY024969, R01EY017607, P30EY001931, T32GM080202, TL1TR001437, and UL1TR001436. This investigation was conducted in part in a facility constructed with support from a Research Facilities Improvement Program, grant number C06RR016511 from the National Center for Research Resources of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support from Vision for Tomorrow and the Gene and Ruth Posner Foundation. Publisher Copyright: Copyright 2020 The Authors.",

year = "2020",

month = mar,

day = "9",

doi = "10.1167/iovs.61.3.36",

language = "English (US)",

volume = "61",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "3",

}

TY - JOUR

T1 - Assessing ganglion cell layer topography in human albinism using optical coherence tomography

AU - Woertz, Erica N.

AU - Omoba, Bisola S.

AU - Dunn, Taylor M.

AU - Chiu, Stephanie J.

AU - Farsiu, Sina

AU - Strul, Sasha

AU - Gail Summers, C.

AU - Drack, Arlene V.

AU - Carroll, Joseph

N1 - Funding Information: Supported by the National Eye Institute, the National Institute of General Medical Sciences, and the National Center for Advancing Translational Science of the National Institutes of Health under award numbers R01EY024969, R01EY017607, P30EY001931, T32GM080202, TL1TR001437, and UL1TR001436. This investigation was conducted in part in a facility constructed with support from a Research Facilities Improvement Program, grant number C06RR016511 from the National Center for Research Resources of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional support from Vision for Tomorrow and the Gene and Ruth Posner Foundation. Publisher Copyright: Copyright 2020 The Authors.

PY - 2020/3/9

Y1 - 2020/3/9

N2 - PURPOSE. To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism. METHODS. Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant. RESULTS. GCL and IPL topography varied between participants. The summed AUC in all quadrants was similar between groups for both the GCL (P = 0.84) and IPL (P = 0.08). Both groups showed nasal-temporal asymmetry in the GCL, but only participants with albinism had nasal-temporal asymmetry in the IPL. Nasal-temporal asymmetry was greater in albinism for both the GCL (P < 0.0001) and the IPL (P = 0.0006). The GCL usually comprised a greater percentage of the combined GCL and IPL in controls than in albinism. CONCLUSIONS. The GCL and IPL have greater structural variability than previously reported. GCL and IPL topography are significantly altered in albinism, which suggests differences in the spatial distribution of retinal ganglion cells. This finding provides insight into foveal development and structure-function relationships in foveal hypoplasia.

AB - PURPOSE. To test whether ganglion cell layer (GCL) and inner plexiform layer (IPL) topography is altered in albinism. METHODS. Optical coherence tomography scans were analyzed in 30 participants with albinism and 25 control participants. Horizontal and vertical line scans were acquired at the fovea, then strip registered and averaged. The Duke Optical Coherence Tomography Retinal Analysis Program was used to automatically segment the combined GCL and IPL and total retinal thickness, followed by program-assisted manual segmentation of the boundary between the GCL and IPL. Layer thickness and area under the curve (AUC) were calculated within 2.5 mm of the fovea. Nasal-temporal and superior-inferior asymmetry were calculated as an AUC ratio in each quadrant. RESULTS. GCL and IPL topography varied between participants. The summed AUC in all quadrants was similar between groups for both the GCL (P = 0.84) and IPL (P = 0.08). Both groups showed nasal-temporal asymmetry in the GCL, but only participants with albinism had nasal-temporal asymmetry in the IPL. Nasal-temporal asymmetry was greater in albinism for both the GCL (P < 0.0001) and the IPL (P = 0.0006). The GCL usually comprised a greater percentage of the combined GCL and IPL in controls than in albinism. CONCLUSIONS. The GCL and IPL have greater structural variability than previously reported. GCL and IPL topography are significantly altered in albinism, which suggests differences in the spatial distribution of retinal ganglion cells. This finding provides insight into foveal development and structure-function relationships in foveal hypoplasia.

KW - Albinism

KW - Foveal development

KW - Foveal hypoplasia

KW - Ganglion cell layer

KW - Optical coherence tomography

KW - Area Under Curve

KW - Intraocular Pressure

KW - Tomography, Optical Coherence

KW - Humans

KW - Male

KW - Albinism, Ocular/diagnostic imaging

KW - Nerve Fibers/pathology

KW - Case-Control Studies

KW - Young Adult

KW - Algorithms

KW - Image Processing, Computer-Assisted

KW - Visual Fields

KW - Adolescent

KW - Adult

KW - Female

KW - Retinal Ganglion Cells/pathology

KW - Child

KW - Observer Variation

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UR - http://www.scopus.com/inward/citedby.url?scp=85082147474&partnerID=8YFLogxK

U2 - 10.1167/iovs.61.3.36

DO - 10.1167/iovs.61.3.36

M3 - Article

C2 - 32196097

AN - SCOPUS:85082147474

SN - 0146-0404

VL - 61

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 3

M1 - 36

ER -

Assessing ganglion cell layer topography in human albinism using optical coherence tomography

Abstract

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Keywords

PubMed: MeSH publication types

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